Use of 1H-NMR spectroscopy to determine the enantioselective mechanism of neutral and anionic cyclodextrins in capillary electrophoresis

Comparative Effects of (SBE)7m‐β‐CD and HP‐β‐CD on the Stability of Two Anti‐neoplastic Agents, Melphalan and Carmustine

“…[29][30][31][32] However, individual protons will shift to varying extents, depending on the nature of the environment they are in and the proximity of anisotropy-producing functional groups. The nonspecific solvent effect of (SBE) 7m -␤-CD or HP-␤-CD on the chemical shifts of various protons is not likely to be a significant factor at the cyclodextrin concentrations used here.…”

Chiral recognition in liquid chromatography utilising chargeable cyclodextrins for resolution of doxazosin enantiomers

“…Optimum enantioselectivity was observed where both selectand and selector were fully ionised implying that ion-pairing was a significant factor in the overall mechanism involved. Further work utilising one-and two-dimensional NMR similar to that recently reported 24 would be required to elucidate fully this complex enantioselective mechanism.…”

Protein‐free ligand screening: simplification of chiral chromatographic development via novel adaptation of NMR screening methodologies

“…Complexation would also be expected to reduce the spin-lattice relaxation time, T 1 , for the affected hydrogens due to an increase in the correlation time, τ c , resulting from restricted hydrogen atom rotation in the ligand-receptor complexes. [23] Accordingly, proton chemical shifts and T 1 's were obtained for solutions of the free ligands, as well as ligand-vancomycin mixtures.…”