Chiral recognition in liquid chromatography utilising chargeable cyclodextrins for resolution of doxazosin enantiomers

LC–MS determination and relative bioavailability of doxazosin mesylate tablets in healthy Chinese male volunteers

“…Several methods have been reported on the determination of doxazosin mesylate, including the use of HPLC for its determination in the plasma and pharmaceutical formulations [6][7][8], differential-pulse-polarography [9][10][11], cathodicstripping voltametry [12], adsorptive stripping voltametry [13], UV spectrophotometry and square-wave voltametry [14], and HPTLC [15]. These methods present some disadvantages such as low sensitivity, poor reproducibility, complicated testing procedures, and requirement of special testing equipment.…”

Development of a Doxazosin and Finasteride Transdermal System for Combination Therapy of Benign Prostatic Hyperplasia

“…As DM has a p K a (the negative logarithm of the ionization constant ( K a) of an acid; equal to the pH value at which half of the acid molecules are ionized) value of 6.93, it is substantially ionized at a pH of 5.5, which indicates a probable negative impact on skin permeation because of a reduction in lipophilicity. Therefore, the preparation of its free base, doxazosin base (DB), would increase the lipophilicity and enhance skin delivery.…”

Enantiomeric resolution of doxazosin mesylate and its process-related substances on polysaccharide chiral stationary phases

“…DXZN enantiomers have been previously separated on cellulase silica [23] and ␣ 1 -acid glyco- protein as chiral stationary phases [24]. Native and substituted ␤-cyclodextrins were used as mobile phase additives in RP-HPLC [25]. LC coupled with tandem mass spectrometry was used to determine the enantiomers of DXZN on Chiralpak AD column in biological fluids [7,26].…”

“…LC coupled with tandem mass spectrometry was used to determine the enantiomers of DXZN on Chiralpak AD column in biological fluids [7,26]. However, these methods do not cover the resolution of the synthetic precursors [23][24][25][26] of DXZN, which is highly needed not only for process development and control but also to optimize the quality of DXZN in finished products.…”