Use of 1000fps high speed x-ray angiography (HSAngio) to quantify differences in flow diversion effects of three stents with different coverage densities in a cerebral aneurysm invitro model

Nagesh, Swetadri Vasan Setlur; Shields, Allison; Wu, Xinlin; Ionita, Ciprian N.; Bednarek, Daniel R.; Rudin, Stephen

doi:10.1117/12.2611754

Cited by 5 publications

(7 citation statements)

References 5 publications

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“…The authors postulate that this method would be of significance in a number of clinical scenarios, such as vascular interventions, where immediate adjustments to the flow and flow-modifying devices can be of potential use in avoiding complications. 24 This can span both the cardio- and neurovascular space, where motion reduction measures and quantification of actual flow parameters are both of interest and value clinically.…”

Section: Discussionmentioning

confidence: 99%

Application of 1,000 fps High-Speed Angiography to In-Vitro Hemodynamic Evaluation of Left Ventricular Assist Device Outflow Graft Configurations

et al. 2023

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Left ventricular assist device (LVAD)-induced hemodynamics are characterized by fast-moving flow with large variations in velocity, making quantitative assessments difficult with existing imaging methods. This study demonstrates the ability of 1,000 fps high-speed angiography (HSA) to quantify the effect of the surgical implantation angle of a LVAD outflow graft on the hemodynamics within the ascending aorta in vitro. High-speed angiography was performed on patientderived, three-dimensional-printed optically opaque aortic models using a nonsoluble contrast media, ethiodol, as a flow tracer. Outflow graft configuration angles of 45° and 90° with respect to the central aortic axis were considered. Projected velocity distributions were calculated from the high-speed experimental sequences using two methods: a physics-based optical flow algorithm and tracking of radio-opaque particles. Particle trajectories were also used to evaluate accumulated shear stress. Results were then compared with computational fluid dynamics (CFD) simulations to confirm the results of the high-speed imaging method. Flow patterns derived from HSA coincided with the impingement regions and recirculation zones formed in the aortic root as seen in the CFD for both graft configurations. Compared with the 45° graft, the 90° configuration resulted in 81% higher two-dimensionalprojected velocities (over 100 cm/s) along the contralateral wall of the aorta. Both graft configurations suggest elevated accumulated shear stresses along individual trajectories. Compared with CFD simulations, HSA successfully characterized the fast-moving flow and hemodynamics in each LVAD graft configuration in vitro, demonstrating the potential utility of this technology as a quantitative imaging modality. ASAIO

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Section: Discussionmentioning

confidence: 99%

Application of 1,000 fps High-Speed Angiography to In-Vitro Hemodynamic Evaluation of Left Ventricular Assist Device Outflow Graft Configurations

et al. 2023

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“…High Speed 1000 fps Angiography is a novel interventional imaging technique previously demonstrated with invitro models representing neurovascular anatomy 1 . Using this imaging technique, details of contrast flow such as flow vortices were easily visualized.…”

Section: Introductionmentioning

confidence: 99%

First in-vivo demonstration of 1000fps High Speed Coronary Angiography (HSCA) in a swine animal model

Setlur Nagesh,

Vanderbilt,

Koenigsknecht

et al. 2024

Medical Imaging 2024: Clinical and Biomedical Imaging

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High-speed-angiography (HSA) 1000 fps imaging was successfully used previously to visualize contrast media/blood flow in neurovascular anatomies. In this work we explore its usage in cardiovascular anatomies in a swine animal model.A 5 French catheter was guided into the right coronary artery of a swine, followed by the injection of iodine contrast through a computer-controlled injector at a controlled rate of 40 (ml/min). The injection process was captured using high-speed angiography at a rate of 1000 fps. The noise in the images was reduced using a custom built machinelearning model consisting of Long Short-term memory networks. From the noise reduced images, velocity profiles of contrast/blood flow through the artery was calculated using Horn-Schunck optical flow (OF) method.From the high-speed coronary angiography (HSCA) images, the bolus of contrast could be visually tracked with ease as it traversed from the catheter tip through the artery. The imaging technique's high temporal resolution effectively minimized motion artifacts resulting from the heart's activity. The OF results of the contrast injection show velocities in the artery ranging from 20 -40 cm/s.The results demonstrate the potential of 1000 fps HSCA in cardiovascular imaging. The combined high spatial and temporal resolution offered by this technique allows for the derivation of velocity profiles throughout the artery's structure, including regions distal and proximal to stenoses. This information can potentially be used to determine the need for stenoses treatment. Further investigations are warranted to expand our understanding of the applications of HSCA in cardiovascular research and clinical practice.

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“…6,7 Single plane HSA analysis of stent deployments have been demonstrated under constant flow. 8 In this work, we perform 1000 fps simultaneous biplane-HSA (SB-HSA) with a physiologically-realistic waveform, and demonstrate how information from these image sequences can differentiate flow features within similarly classified patient-specific ICA aneurysms. Each phantom is imaged pre-and postdeployment of a PED.…”

Section: Introductionmentioning

confidence: 99%

Comparison of pulsatile flow dynamics before and after endovascular intervention in 3D-printed patient-specific internal carotid artery aneurysm models using 1000 fps photon-counting detectors for Simultaneous Biplane High Speed Angiography (SB-HSA)

Vanderbilt

Nagesh

et al. 2023

Medical Imaging 2023: Biomedical Applications in Molecular, Structural, and Functional Imaging

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A significant challenge regarding the treatment of aneurysms is the variability in morphology and analysis of abnormal flow. With conventional DSA, low frame rates limit the flow information available to clinicians at the time of the vascular intervention. With 1000 fps High-Speed Angiography (HSA), high frame rates enable flow details to be better resolved for endovascular interventional guidance. The purpose of this work is to demonstrate how 1000 fps biplane-HSA can be used to differentiate flow features, such as vortex formation and endoleaks, amongst patient-specific internal carotid artery aneurysm phantoms pre-and post-endovascular intervention using an in-vitro flow setup. The aneurysm phantoms were attached to a flow loop configured to a carotid waveform, with automated injections of contrast media. Simultaneous Biplane High-Speed Angiographic (SB-HSA) acquisitions were obtained at 1000 fps using two photon-counting detectors with the respective aneurysm and inflow/ outflow vasculature in the FOV. After x-rays were turned on, the detector acquisitions occurred simultaneously, during which iodine contrast was injected at a continuous rate. A pipeline stent was then deployed to divert flow from the aneurysm, and image sequences were once again acquired using the same parameters. Optical Flow, an algorithm that calculates velocity based on spatial-temporal intensity changes between pixels, was used to derive velocity distributions from HSA image sequences. Both the image sequences and velocity distributions indicate detailed changes in flow features amongst the aneurysms before and after deployment of the interventional device. SB-HSA can provide detailed flow analysis, including streamline and velocity changes, which may be beneficial for interventional guidance.

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Use of 1000fps high speed x-ray angiography (HSAngio) to quantify differences in flow diversion effects of three stents with different coverage densities in a cerebral aneurysm invitro model

Cited by 5 publications

References 5 publications

Application of 1,000 fps High-Speed Angiography to In-Vitro Hemodynamic Evaluation of Left Ventricular Assist Device Outflow Graft Configurations

Application of 1,000 fps High-Speed Angiography to In-Vitro Hemodynamic Evaluation of Left Ventricular Assist Device Outflow Graft Configurations

First in-vivo demonstration of 1000fps High Speed Coronary Angiography (HSCA) in a swine animal model

Comparison of pulsatile flow dynamics before and after endovascular intervention in 3D-printed patient-specific internal carotid artery aneurysm models using 1000 fps photon-counting detectors for Simultaneous Biplane High Speed Angiography (SB-HSA)

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