2022
DOI: 10.3390/nu14153004
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Use of 1-MNA to Improve Exercise Tolerance and Fatigue in Patients after COVID-19

Abstract: COVID-19 is not only a short-term infection, as patients (pts) recovering from SARS-CoV-2 infection complain of persisting symptoms, which may lead to chronic fatigue syndrome. There is currently no evidence that nutritional supplements can assist in the recovery of pts with chronic fatigue syndrome. 1-Methylnicotinamide (1-MNA) is an endogenic substance that is produced in the liver when nicotinic acid is metabolized. 1-MNA demonstrates anti-inflammatory and anti-thrombotic properties. Therefore, we investiga… Show more

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Cited by 6 publications
(5 citation statements)
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“…They can also be used to identify potential treatments to improve exercise tolerance and fatigue in patients after COVID-19, as is being demonstrated by one of the co-authors. 28 …”
Section: Resultsmentioning
confidence: 99%
“…They can also be used to identify potential treatments to improve exercise tolerance and fatigue in patients after COVID-19, as is being demonstrated by one of the co-authors. 28 …”
Section: Resultsmentioning
confidence: 99%
“…As mentioned above, vitamin C [ 994 ] is to be recommended only if one is sure that free or poorly liganded iron is absent. Niacin (vitamin B 3 ) may also be of value in a tapered-up strategy, since NAD+ levels are known to be lowered in COVID-19 [ 995 ] and other viral infections [ 996 ]; its metabolite 1-methylnicotinamide has also shown promise in Long COVID [ 997 ].…”
Section: Anticoagulants Platelet Inhibitors and The Triple Treatmentmentioning
confidence: 99%
“…69 70 Exercise impairments are a common feature of post-COVID-19 sequelae. [71][72][73][74][75][76][77] Poorer performance on the 6 min walk test (6MWT) was associated with fatigue and lower vitality at 6 months despite no concomitant impairments in pulmonary functions. 78 Indeed, impairments in lung functions have not thus far fully explained worse fatigue in COVID-19.…”
Section: Strengths and Limitations Of This Studymentioning
confidence: 99%
“…Being over 50 years was associated with fatigue severity in some studies,52 67 68 but not in others 69 70. Exercise impairments are a common feature of post-COVID-19 sequelae 71–77. Poorer performance on the 6 min walk test (6MWT) was associated with fatigue and lower vitality at 6 months despite no concomitant impairments in pulmonary functions 78.…”
Section: Introductionmentioning
confidence: 99%