Use-Dependent Exaggeration of Brain Injury: Is Glutamate Involved?

Humm, J. Leigh; Kozlowski, Dorothy A.; Bland, Sondra T.; James, Debra C.; Schallert, Timothy

doi:10.1006/exnr.1999.7061

Cited by 110 publications

(55 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The latter result raises the possibility of a limit on the amount of RA training that is beneficial. Expansion of neural injury and reduced restoration of function associated with early forced use of a forelimb after unilateral brain injury has been seen in rats [37][38][39][40]. Although the applicability of these results to human trials has not been demonstrated, they point out the need to consider intensity, total dose, and timing of training in trials of novel therapeutic methods and devices.…”

Section: Discussionmentioning

confidence: 97%

Robot-assisted upper-limb therapy in acute rehabilitation setting following stroke: Department of Veterans Affairs multisite clinical trial

Burgar¹,

Lum²,

Scremin³

et al. 2011

JRRD

152

View full text Add to dashboard Cite

Abstract-This randomized, controlled, multisite Department of Veterans Affairs clinical trial assessed robot-assisted (RA) upper-limb therapy with the Mirror Image Movement Enabler (MIME) in the acute stroke rehabilitation setting. Hemiparetic subjects (n = 54) received RA therapy using MIME for either up to 15 hours (low-dose) or 30 hours (high-dose) or received up to 15 hours of additional conventional therapy in addition to usual care (control). The primary outcome measure was the FuglMeyer Assessment (FMA). The secondary outcome measures were the Functional Independence Measure (FIM), Wolf Motor Function Test, Motor Power, and Ashworth scores at intake, discharge, and 6-month follow-up. Mean duration of study treatment was 8.6, 15.8, and 9.4 hours for the low-dose, high-dose, and control groups, respectively. Gains in the primary outcome measure were not significantly different between groups at follow-up. Significant correlations were found at discharge between FMA gains and the dose and intensity of RA. Intensity also correlated with FMA gain at 6 months. The high-dose group had greater FIM gains than controls at discharge and greater tone but no difference in FIM changes compared with low-dose subjects at 6 months. As used during acute rehabilitation, motor-control changes at follow-up were no less with MIME than with additional conventional therapy. Intensity of training with MIME was positively correlated with motor-control gains.Clinical Trial Registration: ClinicalTrials.gov, NCT00223808, "Assisted Movement Neuro-rehabilitation: VA Multi-site Clinical Trial"; http://www.clinicaltrials.gov/ct2/show/NCT00223808

show abstract

Section: Discussionmentioning

confidence: 97%

Robot-assisted upper-limb therapy in acute rehabilitation setting following stroke: Department of Veterans Affairs multisite clinical trial

Burgar¹,

Lum²,

Scremin³

et al. 2011

JRRD

152

View full text Add to dashboard Cite

show abstract

“…Left DNB lesions had no effect on motor performance in rats with a subsequent sham sensorimotor cortex lesion. Cortex-lesioned rats with prior left DNB lesions had significantly impaired recoveries (areas under the time-effect curves) compared with cortex-lesioned rats with sham DNB lesions (ANOVA F 3,16 , p Ͻ 0.001; left DNB lesion-cortex lesion versus sham DNB lesion-cortex lesion, Fisher's LSD, p Ͻ 0.02). The right upper panel gives the correlation between recovery and norepinephrine content in the left cerebral hemisphere and the right lower panel shows the lack of correlation between recovery and norepinephrine content in the right cerebral hemisphere in these same animals.…”

Section: Figmentioning

confidence: 99%

Neurotransmitters and motor activity: Effects on functional recovery after brain injury

Goldstein

2006

NeuroRX

View full text Add to dashboard Cite

Summary: There are complex relationships among behavioral experience, brain morphology, and functional recovery of an animal before and after brain injury. A large series of experimental studies have shown that exogenous manipulation of central neurotransmitter levels can directly affect plastic changes in the brain and can modulate the effects of experience and training. These complex relationships provide a formidable challenge for studies aimed at understanding neurotransmitter effects on the recovery process. Experiments delineating norepinephrine-modulated locomotor recovery after injury to the cerebral cortex illustrate the close relationships among neurotransmitter levels, brain plasticity, and behavioral recovery. Understanding the neurobiological processes underlying recovery, and how they might be manipulated, may lead to novel strategies for improving recovery from stroke-related gait impairment in humans.

show abstract

“…32,33 Sağlıklı beyinde dahi risk oluşturabilecek şiddette egzersiz ile beyin hasarı sonrasında da risk artmaktadır. 34 Ayrıca travmatik beyin yaralanması sonrasında, egzersize verilen antiinflamatuar yanıtlarda gecikme olduğu, IL-6 ve IL-10 ya- nıtları, hipotalamo-adrenal aks ritminin geciktiği ça-lışmalarda gösterilmiştir. 30 Baskılanmış veya geciken antiinflamatuar yanıtların hasarlı beyinde stres riskini artıracağı bilinen bir durumdur.…”

Section: Egzersi̇zi̇n İnflamatuar Ve Metaboli̇k Yanitlara Etki̇si̇unclassified

“…30 Baskılanmış veya geciken antiinflamatuar yanıtların hasarlı beyinde stres riskini artıracağı bilinen bir durumdur. 30,[32][33][34] Deneysel kesitlerde, travma sonrası en erken beşinci haftada ve orta şiddette, üç ay süreyle uygulanan egzersiz sonrasında mikroglial inflamatuar yanıtta azalma, motor ve bilişsel yanıtta düzelme gösterildiği bildirilmiştir. 35 Kafa travması sonrasında erken dönemde, şiddetli egzersizi önermeyen ve düşük dirençte, ritmik, dinamik egzersizlerin yaşa göre adapte edilerek maksimal kalp hızının %60'ı kapasitesinde, 20-40 dk süreli ve haftada üç kez uygulanmasını öneren çalışmalar mevcuttur.…”

Section: Egzersi̇zi̇n İnflamatuar Ve Metaboli̇k Yanitlara Etki̇si̇unclassified

Brain and Exercise: Review

Meray¹,

Yenice²

2018

J PMR Sci

View full text Add to dashboard Cite

Use-Dependent Exaggeration of Brain Injury: Is Glutamate Involved?

Cited by 110 publications

References 48 publications

Robot-assisted upper-limb therapy in acute rehabilitation setting following stroke: Department of Veterans Affairs multisite clinical trial

Robot-assisted upper-limb therapy in acute rehabilitation setting following stroke: Department of Veterans Affairs multisite clinical trial

Neurotransmitters and motor activity: Effects on functional recovery after brain injury

Brain and Exercise: Review

Contact Info

Product

Resources

About