Purpose: This study aims to examine the effects of activity groups using art activities on resilience and related factors in mothers with disabled children. Design and Methods: This randomized controlled experimental design study was conducted with 33 mothers (18 in the control and 15 in the intervention group). Findings: A statistically significant difference was found between the intervention group's pretest and posttest mean scores on the Resilience Scale for Adults, the Satisfaction with Life Scale, Zarit Burden Interview, and 12-item General Health Questionnaire scales. Implications for Nursing Practice: The psychological activity groups that used art activities were found to increase psychological well-being and satisfaction with life among the families of disabled children with various types of distress (physical, psychological, economic, and social), as well as reducing their mothers' perceived caregiving burden.