Use and comparative assessment of the CVFEM method for Poisson–Boltzmann and Poisson–Nernst–Planck three dimensional simulations of impedimetric nano-biosensors operated in the DC and AC small signal regimes

Pittino, Federico; Selmi, L.

doi:10.1016/j.cma.2014.06.006

Cited by 33 publications

(15 citation statements)

References 30 publications

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“…Following the assumption that the bulk concentration c 0 is much larger than c i1 , c 0 ≫ c i1 this model has an analytical solution and can serve as a benchmark for the numerical computations . The application of PNP with slight modifications is used for Li‐batteries simulation,, transport, biosensors, etc .…”

Section: Circuit Modelling Data Interpretation and Validationmentioning

confidence: 99%

Electrochemical Impedance Spectroscopy Based Biosensors: Mechanistic Principles, Analytical Examples and Challenges towards Commercialization for Assays of Protein Cancer Biomarkers

et al. 2018

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affinity biosensors are, without any doubt, among the most sensitive analytical devices available, offering low limits of detection and wide linear response ranges. There are, however, only a few papers detailing the application of impedimetric biosensors for the analysis of clinically relevant samples with due clinical performance. The fact that these devices have not found their way to any commercial or clinical use to date might be surprising, since an electrochemical assay platform based on portable potentiostats is a success story for monitoring a range of clinical parameters such as ions, haematological indicators and glucose. This review discusses the reasons behind this discrepancy and addresses the barriers to be overcome in order to achieve the point-of-care diagnostics using such devices for detection of protein oncomarkers approved by FDA. The final part of the review covers the most recent progress in the area.[a] Dr.

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Section: Circuit Modelling Data Interpretation and Validationmentioning

confidence: 99%

Electrochemical Impedance Spectroscopy Based Biosensors: Mechanistic Principles, Analytical Examples and Challenges towards Commercialization for Assays of Protein Cancer Biomarkers

et al. 2018

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“…A microsphere induces position-dependent changes in the electrodes' switching capacitances, ΔC exp . To quantitatively elucidate the signal transduction mechanism, we performed extensive three-dimensional finite-element simulations (Supplementary Sections IV and V) based on the Poisson-Nernst-Planck formalism 14 in the frequency domain using a numerical simulator reported previously 15 . Figure 1e shows a map of the a.c. potential amplitude generated by three electrodes in 150 mM salt at zero d.c. bias and a 10 kHz modulation frequency typical of conventional electrochemical impedance spectroscopy 14,16 .…”

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confidence: 99%

Real-time imaging of microparticles and living cells with CMOS nanocapacitor arrays

et al. 2015

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Platforms that offer massively parallel, label-free biosensing can, in principle, be created by combining all-electrical detection with low-cost integrated circuits. Examples include field-effect transistor arrays, which are used for mapping neuronal signals and sequencing DNA. Despite these successes, however, bioelectronics has so far failed to deliver a broadly applicable biosensing platform. This is due, in part, to the fact that d.c. or low-frequency signals cannot be used to probe beyond the electrical double layer formed by screening salt ions, which means that under physiological conditions the sensing of a target analyte located even a short distance from the sensor (∼1 nm) is severely hampered. Here, we show that high-frequency impedance spectroscopy can be used to detect and image microparticles and living cells under physiological salt conditions. Our assay employs a large-scale, high-density array of nanoelectrodes integrated with CMOS electronics on a single chip and the sensor response depends on the electrical properties of the analyte, allowing impedance-based fingerprinting. With our platform, we image the dynamic attachment and micromotion of BEAS, THP1 and MCF7 cancer cell lines in real time at submicrometre resolution in growth medium, demonstrating the potential of the platform for label/tracer-free high-throughput screening of anti-tumour drug candidates.

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“…For the ion-penetrable bacterial cell wall, the ionic diffusion coefficient is assumed 40% of the one of the surrounding electrolyte [26]. The ion transport is described by the Nernst-Planck equation [20,34,35]:…”

Section: Constitutive Equationsmentioning

confidence: 99%

“…Instead of analytical models, 2D or 3D electrostatic simulations have been reported to accurately quantify the sensitivity to bacterial cells depending on their random positions on the 3D electrode topology [16], their number [16,17] and the thickness of the passivation layer [13]. Such 2D or 3D simulations have also been implemented to analyze the impact of the applied frequency on the sensor impedance [18] and sensitivity [19][20][21] of nanometer-scale biomolecules.…”

Section: Introductionmentioning

confidence: 99%

Capacitive biosensing of bacterial cells: Analytical model and numerical simulations

Couniot

Afzalian

Overstraeten

et al. 2015

Sensors and Actuators B: Chemical

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Use and comparative assessment of the CVFEM method for Poisson–Boltzmann and Poisson–Nernst–Planck three dimensional simulations of impedimetric nano-biosensors operated in the DC and AC small signal regimes

Cited by 33 publications

References 30 publications

Electrochemical Impedance Spectroscopy Based Biosensors: Mechanistic Principles, Analytical Examples and Challenges towards Commercialization for Assays of Protein Cancer Biomarkers

Electrochemical Impedance Spectroscopy Based Biosensors: Mechanistic Principles, Analytical Examples and Challenges towards Commercialization for Assays of Protein Cancer Biomarkers

Real-time imaging of microparticles and living cells with CMOS nanocapacitor arrays

Capacitive biosensing of bacterial cells: Analytical model and numerical simulations

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