Urticaria and Thyroid Autoimmunity

Bagnasco, Marcello; Minciullo, Paola Lucia; Schiavo, Mara; Saraceno, Giovanna; Gangemi, Sebastiano; Benvenga, Salvatore

doi:10.1089/thy.2010.0103

Cited by 51 publications

(50 citation statements)

References 80 publications

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“…In general, urticaria is a very common skin disorder that can have immune, non-immune or idiopathic causes [9]. The idiopathic urticaria is accounted for in 75% of all urticaria cases [10]. Skin lesions appearing within a six-week period characterize acute urticaria, whereas chronic urticaria is defined as the presence of urticaria over a longer period of time.…”

Section: Introductionmentioning

confidence: 99%

Eradication of Blastocystis hominis prevents the development of symptomatic Hashimoto’s thyroiditis: a case report

Rajič

Arapović

Raguž³

et al. 2015

J Infect Dev Ctries

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In this case report we describe a 49 year-old man who presented with chronic urticaria, angioedema and soft stool consistency. During diagnostic examinations Hashimoto's thyroiditis was found even though the patient never had clear symptoms of this disease. Blastocystis hominis was isolated through a stool microbiologic examination, implicating that this parasite can cause the development of Hashimoto's thyroiditis and chronic urticaria. After two-weeks treatment with metronidazole the Blastocystis hominis was eradicated, then urticaria and angioedema disappeared. During the four years of follow-up, the patient presented without any symptoms, whereas thyroid hormones were normalized and anti-thyroid antibodies declined. For the first time in the literature we show that eradication of Blastocystis hominis can prevent the development of both symptomatic Hashimoto's thyroiditis and chronic urticaria.

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Section: Introductionmentioning

confidence: 99%

Eradication of Blastocystis hominis prevents the development of symptomatic Hashimoto’s thyroiditis: a case report

Rajič

Arapović

Raguž³

et al. 2015

J Infect Dev Ctries

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“…At least in a subset of patients, CSU has an autoimmune basis, as demonstrated by the presence of antibodies against the α-subunit of the high-affinity IgE receptor (Fc ε RI α ), or against IgE itself in the serum of 30%-40% of such patients (1)(2)(3). The association of CSU with thyroid autoimmunity further supports its autoimmune origin (4). CSU patients frequently suffer from Hashimoto's thyroiditis and increased serum levels of anti-thyroid antibodies were reported in 10% to 33% CSU patients (4,5).…”

Section: Sumáriomentioning

confidence: 90%

“…The association of CSU with thyroid autoimmunity further supports its autoimmune origin (4). CSU patients frequently suffer from Hashimoto's thyroiditis and increased serum levels of anti-thyroid antibodies were reported in 10% to 33% CSU patients (4,5). Coexisting Graves' disease (GD) has been reported less frequently than HT, with an estimated preva lence ranging from 1% to 4% (6).…”

Section: Sumáriomentioning

confidence: 91%

The unusual association of Graves' disease, chronic spontaneous urticaria, and premature ovarian failure: report of a case and HLA haplotype characterization

Ruggeri¹,

Vita²,

D'Angelo

et al. 2013

Arq Bras Endocrinol Metab

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SUMMARYChronic spontaneous urticaria (CSU), defined as the occurrence of spontaneous wheals for more than six weeks, has been associated with autoimmune diseases. Herein, we report the unusual association of CSU, Graves' disease, and premature ovarian failure. Human leukocyte antigen (HLA) studies were performed. A 36-year-old woman presented symptoms and signs of hyperthyroidism for three months. In the same period, the patient complained of widespread urticarial wheals, intensely itchy, and poorly responsive to therapy with antihistaminic agents. Hyperthyroidism was confirmed biochemically, and treatment with methimazole was started. As hyperthyroidism improved, a marked improvement in her urticaria was also observed. However, the patient continued to complain of amenorrhea. Endocrine evaluation, at the age 38, was consistent with premature ovarian failure. This is the first report of coexistence of GD, CSU, and POF. The genetic background of such unusual association is a specific combination of HLA. Arq Bras Endocrinol Metab. 2013;57(9):748-52 SUMÁRIO A urticária crônica idiopática, caracterizada pelo aparecimento de pápulas espontâneas e persistentes por pelo menos seis semanas, tem sido associada a doenças autoimunes. Apresentamos aqui o caso da associação incomum entre urticária crônica idiopática, doença de Graves e falência ovariana prematura. Foram conduzidos estudos de tipagem HLA. Uma mulher de 36 anos apresentou sinais e sintomas de hipertireoidismo por três meses. No mesmo período, a paciente queixou-se do aparecimento de pápulas urticariformes generalizadas que coçavam intensamente e não eram responsivas ao tratamento com anti-histamínicos. O hipertireoidismo foi confirmado bioquimicamente, e o tratamento com metimazol foi iniciado. Assim que os valores hormonais se normalizaram, observou-se uma melhoria significativa do quadro de urticária. No entanto, a paciente continuou a apresentar amenorreia. A avaliação endocrinológica, com a idade de 38 anos, mostrou falência ovariana prematura. Este é o primeiro caso de associação entre doença de Graves, urticária idiopática crônica e falência ovariana prematura. A base genética dessa associação incomum é representada por combinações específicas de haplótipos HLA. Arq Bras Endocrinol Metab. 2013;57(9):748-52

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“…Our findings are consistent with these results. Another study carried out several decades ago proposed a link between chronic urticaria and autoimmune thyroid diseases, although the mechanisms of the apparent association between chronic urticaria and serological evidence of thyroid autoimmunity were not clear (48). A group of researchers has suggested that there could be a skin mast cell autoreactivity in HT patients, irrespective of autoreactive chronic urticaria (49).…”

Section: Discussionmentioning

confidence: 99%

Coexistence of Autoimmune and Allergic Diseases with Autoimmune Thyroid Diseases

Duran¹,

Ağbaht²,

Soykan³

et al. 2017

Turk J Endocrinol Metab

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C Co oe ex xi is st te en nc ce e o of f A Au ut to oi im mm mu un ne e a an nd d A Al ll le er rg gi ic c D Di is se ea as se es s w wi it th h A Au ut to oi im mm mu un ne e T Th hy yr ro oi id d D Di is se ea as se es s O Ot to oi im mm mü ün n T Ti ir ro oi id d H Ha as st ta al lı ık kl la ar rı ıy yl la a B Bi ir rl li ik kt te e S Se ey yr re ed de en n O Ot to oi im mm mü ün n v ve e A Al ll le er rj ji ik k H Ha as st ta al lı ık kl la ar r Ankara University Faculty of Medicine, Department of Endocrinology and Metabolic Diseases, Ankara, Turkey *Ankara University Faculty of Medicine, Department of Gastroenterohepatology, Ankara, Turkey Background: Sometimes, the patients with autoimmune thyroiditis show certain symptoms despite having serum thyroid hormone levels within the desired range. In addition, the dose of levothyroxine replacement may vary in the patients with hypothyroidism. These factors directly inuence clinical practices and may, to some extent, be associated with other immunological/allergic diseases that accompany autoimmune thyroid diseases (ATDs). Purpose: To document the other autoimmune/allergic disorders in patients during follow-up for ATDs. Materials and Methods: During the study period, 274 patients diagnosed with, and/or at follow-up for Hashimoto's thyroiditis (HT), and 53 with Graves' disease (GD) were included in the study. All the patients were examined and were subjected to further investigations when the presence of other autoimmune/allergic diseases was suspected.Results: A total of 65 patients with HT (23.8%) and seven patients with GD (13.2%) had at least one additional clinical autoimmune/allergic disorder. Twentyeight (10.2%) patients with HT had gastrointestinal disorders (chronic atrophic gastritis and celiac disease), 19 (6.6%) had allergies (asthma, chronic urticaria, and rhinosinusitis), 12 (4.4%) had rheumatological disorders (rheumatoid arthritis), 10 (3.7%) had skin problems (vitiligo and psoriasis), four (1.5%) had endocrinological disorders (hypoparathyroidism, type-1 diabetes mellitus, and hypophysitis), one (0.4%) had hematological disease (idiopathic thrombocytopenic purpura), and one (0.4%) had renal disorder (crescentic glomerulonephritis). The prevalence patterns were similar in the patients with GD. In addition, 50 (18.2%) patients with HT and one (1.9%) with GD were observed to have vitamin B12 decient-anemia (p=0.001). Furthermore, 28 (10.2%) patients with HT and one (1.9%) with GD had dimorphic anemia (both vitamin B12 and iron deciencies). Discussion: The patients with ATDs are prone to additional autoimmune/allergic diseases, and it can be said that the patients with autoimmune thyroid diseases sometimes have more than just thyroid disease. The most involved organ system in both HT and GD is the gastrointestinal tract. This involvement probably plays a role in the exacerbation of some symptoms by causing anemia resulting from a deciency of both vitamin B12 and iron, especially in patients with HT.

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Urticaria and Thyroid Autoimmunity

Cited by 51 publications

References 80 publications

Eradication of Blastocystis hominis prevents the development of symptomatic Hashimoto’s thyroiditis: a case report

Eradication of Blastocystis hominis prevents the development of symptomatic Hashimoto’s thyroiditis: a case report

The unusual association of Graves' disease, chronic spontaneous urticaria, and premature ovarian failure: report of a case and HLA haplotype characterization

Coexistence of Autoimmune and Allergic Diseases with Autoimmune Thyroid Diseases

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