Eradication of Blastocystis hominis prevents the development of symptomatic Hashimoto’s thyroiditis: a case report

Rajič, Borko; Arapović, Jurica; Raguž, Kazimir; Bošković, Mladen; Babić, Senaida Marina; Maslac, S. Kackov

doi:10.3855/jidc.4851

Cited by 12 publications

(6 citation statements)

References 19 publications

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“…13 In 2015, for the first time in the literature a case report was published showing that treatment of BH infection can prevent the development and further stop progression of HT. 14 Our results supported those of the case report, we showed that treatment of BH infection in patients with HT resulted in a significant reduction in TSH and anti-TPO, which subsequently improved HT. Also, serum level of IL-17, a cytokine thought to have a role in HT pathogenesis, was decreased significantly after BH eradication that further supported the improvement of HT following treatment of BH infection.…”

Section: Discussionsupporting

confidence: 92%

Improving Hashimoto’s thyroiditis by eradicating Blastocystis hominis: Relation to IL-17

El‐Zawawy

Farag

Tolba

et al. 2020

Therapeutic Advances in Endocrinology

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Background: Hashimoto’s thyroiditis (HT) is a common autoimmune disorder that causes significant morbidity. Interleukin (IL)-17 was identified as a major contributing factor in the pathogenesis of HT. Blastocystis hominis (BH) is a very common infection and has been shown to be associated with several diseases. Our aim was to determine serum IL-17 level in HT patients with and without BH infection and the effect of eradicating BH in patients with HT. Methods: A prospective cohort study was conducted on 20 HT patients not infected with BH (group I), 20 HT patients infected with BH (group II), and 20 healthy patients (group III). Serum free triiodothyronine (FT3), free thyroxine (FT4), thyroid stimulating hormone (TSH), thyroid peroxidase antibodies (anti-TPO), and IL-17 were performed by ELISA method and were repeated in group II after 6 weeks of eradication of BH. Results: Patients with HT showed a significantly higher serum IL-17 compared with controls. IL-17 was significantly higher in HT patients infected with BH compared with HT patients not BH infected (mean 6.93 ± 2.83 pg/ml versus 3.25 ± 1.55 pg/ml, p = 0.003). After BH eradication TSH, anti-TPO, and IL-17 were significantly decreased (mean 14.76 ± 11.11 µIU/ml versus 9.39 ± 7.11 µIU/ml, p < 0.001; mean 308 ± 175.6 IU/ml versus 295.4 ± 167.1 IU/ml, p = 0.006; and mean 6.93 ± 2.83 pg/ml versus 6.45 ± 2.48 pg/ml, p < 0.001), respectively. Multivariate analysis after treating BH infection showed that IL-17 was significantly negatively correlated with FT3 (adjusted p = 0.002) and significantly positively correlated with anti-TPO (adjusted p = 0.045). Conclusion: Treatment of BH infection ameliorates HT through reduction in IL-17, anti-TPO, and TSH. Clinical trial registration number: PACTR201909495111649

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Section: Discussionsupporting

confidence: 92%

Improving Hashimoto’s thyroiditis by eradicating Blastocystis hominis: Relation to IL-17

El‐Zawawy

Farag

Tolba

et al. 2020

Therapeutic Advances in Endocrinology

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“…Inicialmente fue considerado un comensal; sin embargo, en las últi-mas décadas hay cada vez más evidencias que sustentan que Blastocystis spp. es patógeno y se asocia a una amplia variedad de trastornos gastrointestinales simples (dolor abdominal, diarrea, flatulencia, vómitos) (2,3) y cuadros más complejos, como anemia ferropéni-ca (2) , urticaria (2,4) , síndrome de intestino irritable (2,5,6) , cáncer colorrectal (7)(8)(9) , artritis reactiva (10) e incluso tiroiditis de Hashimoto (11) . El conocimiento de sus múltiples impactos sobre la salud llevó a que se le preste más atención, por lo que probablemente la prevalencia de blastocistosis se haya incrementado en los últimos años.…”

Section: Introductionunclassified

Elevada prevalencia de Blastocystis spp. en niños de una escuela periurbana

2016

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ResumenIntroducción. La parasitosis intestinal es un grave problema de salud pública en países en vía de desarrollo; la blastocistosis es una parasitosis emergente. Objetivos. Determinar la prevalencia de infección por Blastocystis spp. y de otros enteroparásitos en niños de una escuela periurbana. Diseño. Estudio observacional y transversal. Lugar. Escuela ubicada en el distrito de Yura en Arequipa, Perú. Participantes. 83 niños, entre 4 y 8 años de edad. Intervenciones. Las muestras de heces de los niños fueron analizadas con el método Teleman modificado; se hizo un análisis descriptivo a través del cálculo de frecuencias. Principales medidas de resultados. Presencia del parásito intestinal. Resultados. La prevalencia de Blastocystis spp. fue 81,9% (68/83), la prevalencia global de parásitos fue 96,4% (80/83); además, 80,7% (67/83) tenía más de un tipo de parásito. Conclusiones. Existe una elevada prevalencia de Blastocystis spp. y de otros enteroparásitos; también, un elevado poliparasitismo en la población escolar estudiada. Es el primer estudio realizado en dicha comunidad. Palabras clave. Infecciones por Blastocystis; Parasitosis Intestinales; Niño; Perú. Abstract Introduction. Intestinal parasitosis is a serious public health problem in developing countries, and blastocystosis is an emerging parasitosis. Objectives. To determine the prevalence of infection by Blastocystis spp. and other intestinal parasites in children from a periurban school. Design. Observational and transversal study. Location. A school located in the district of Yura in Arequipa, Peru. Participants. 83 children between 4 and 8 years old. Interventions. Stool samples obtained from the children were analyzed with the modified Telemann method; a descriptive analysis was done by calculating frequency. Main outcome measures. Presence of the intestinal parasite. Results. The prevalence of Blastocystis spp. was 81.9% (68/83), the overall prevalence of parasites was 96.4% (80/83), and 80.7% (67/83) had more than one type of parasite. Conclusions. There was a high prevalence of Blastocystis spp. and other intestinal parasites in the sample studied. There was also a high polyparasitism in the school population studied. This is the first study in this community.

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“…In this study, 57.1% of pre- and perimenopausal women with ST2 suffered from a thyroid disease (Hashimoto’s disease). Rajič et al [ 107 ] provided evidence that the eradication of Blastocystis spp. can prevent the development of both symptomatic Hashimoto’s thyroiditis and chronic urticaria.…”

Section: Discussionmentioning

confidence: 99%

Prevalence, subtypes and risk factors of Blastocystis spp. infection among pre- and perimenopausal women

et al. 2021

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Background Blastocystis spp. are considered pathogenic or commensal organisms, although the majority of researchers suggest that these are neglected pathogens. The main aim of this study was to determine the prevalence and subtype distribution of Blastocystis spp. in pre- and perimenopausal women, with respect to socio-demographic (age and place of residence), and epidemiological factors, as well as drinking tap water, contact with domestic animals, traveling abroad, health status, and presence of gastrointestinal symptoms. Additionally, the objective was to compare hematological and biochemical parameters of Blastocystis spp. infected and uninfected women. Methods The study included 425 women aged 45–60. Their stool samples were examined microscopically and analyzed by a conventional polymerase chain reaction (cPCR). Results Blastocystis spp. were detected in 6.1% of pre- and perimenopausal women. Molecular analysis of the stool samples identified seven Blastocystis subtypes (ST1–ST4, ST6, ST7, and ST9). Blastocystis subtypes 2 and 3 were the most prevalent. The presence of Blastocystis spp. was not significantly related to socio-demographic and epidemiological factors. There were also no significant associations between Blastocystis spp. and blood parameters, or gastrointestinal symptoms. Conclusion This study complements the limited available data on the prevalence of Blastocystis spp. in pre- and perimenopausal women. It is also the first report showing the presence of Blastocystis subtype 9 in Poland.

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Eradication of Blastocystis hominis prevents the development of symptomatic Hashimoto’s thyroiditis: a case report

Cited by 12 publications

References 19 publications

Improving Hashimoto’s thyroiditis by eradicating Blastocystis hominis: Relation to IL-17

Improving Hashimoto’s thyroiditis by eradicating Blastocystis hominis: Relation to IL-17

Elevada prevalencia de Blastocystis spp. en niños de una escuela periurbana

Prevalence, subtypes and risk factors of Blastocystis spp. infection among pre- and perimenopausal women

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