Urticaria and infections

Wedi, Bettina; Raap, Ulrike; Wieczorek, D.; Kapp, Alexander

doi:10.1186/1710-1492-5-10

Cited by 173 publications

(184 citation statements)

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“…In 2009, Wedi et al (3) reported the benefits of the eradication of this bacteria in patients with ChU in 13 studies (including a total of 322 patients), against 9 studies (164 patients) showing no benefits. In the studies that demonstrated the treatment to be beneficial, 84% of the patients showed either significant improvement or complete remission of the ChU after the bacterial eradication, in contrast with 45% of the patients who were infected but not treated, and 29% of the noninfected and not treated patients.…”

Section: Discussionmentioning

confidence: 99%

“…Urticaria is a mucocutaneous disease characterized by erythematous, edematous and pruritic lesions of the dermis and/or hypodermis, resulting from the degranulation of mast cells and basophils and the release of inflammatory mediators, mainly histamine (1)(2)(3)(4) . It affects from 15 to 25% of the population at some stage of life, and is classified as acute (lesions lasting less than six weeks) or chronic, when the lesions last for more than six weeks, either daily or on most days of the week (1) .…”

Section: Introductionmentioning

confidence: 99%

“…Finally, the presence of the Helicobacter pylori in the gastric mucosa stimulates the activated eosinophils to release cytotoxic proteins, which are involved in the pathophysiology of urticaria, and interfere with the production of pro-inflammatory cytokines and with the expression of epitopes of adhesion to the endothelial cells, which triggers a systemic immune response (5) . Also, substances produced by the Helicobacter pylori, such as urease, protease, phospholipase and cytokines, can trigger the complement response (3) .…”

Section: Introductionmentioning

confidence: 99%

“…Several etiologic factors for ChU have been described, among them the chronic infections and the parasitic infestations (1,3,7) . The infection by Helicobacter pylori has been the subject of investigation as a possible etiologic factor for ChU in the last few years (3,5,(7)(8)(9)(10)(11) .…”

Section: Introductionmentioning

confidence: 99%

“…The infection by Helicobacter pylori has been the subject of investigation as a possible etiologic factor for ChU in the last few years (3,5,(7)(8)(9)(10)(11) . Helicobacter pillory affects nearly 50% of the world population (12) .…”

Section: Introductionmentioning

confidence: 99%

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Recidiva de urticária crônica decorrente de reinfecção por Helicobacter pylori

Bruscky¹,

Rocha²,

Costa³

2013

Rev. paul. pediatr.

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Objective: To describe a case of chronic urticaria in a female adolescent associated with Helicobacter pylori infection, confirmed in two different occasions, with improvement of urticaria after the antibacterial treatment.Case description: A 13-year-old female patient sought medical care with chronic urticaria and epigastric pain unresponsive to medical treatment. Laboratorial tests for further investigation were normal except for the upper gastrointestinal endoscopy with biopsy showing moderate chronic active gastritis associated with Helicobacter pylori. After specific and appropriate treatment, the patient had remission of the symptoms. A new upper gastrointestinal endoscopy to control the treatment after nine months was normal. After five years, the patient returned with recurrence of urticaria and epigastric pain. She was taking antihistamines, without any improvement. It was again submitted to screening protocol for chronic urticaria with normal results. She was submitted to upper gastrointestinal endoscopy, which showed positive urease test. The patient started a new treatment for Helicobacter pylori with disappearance of chronic urticaria and epigastric pain within seven days.Comments: The reported case suggests a causal relationship between the positive diagnosis of Helicobacter pylori and the occurrence of chronic urticaria, showing the remission of symptoms after the institution of effective therapy for this agent. Chronic urticaria is a disease of complex etiology, and although controversial, there is growing evidence of Helicobacter pylori involvement with extraintestinal diseases, including chronic urticaria.Key-words: urticaria; Helicobacter pylori; adolescent. RESUMOObjetivo: Descrever, em uma adolescente do sexo feminino, o caso clínico de urticária crônica associado à infecção por Helicobacter pylori confirmado em dois momentos distintos, com melhora após a terapêutica antibacteriana.Descrição do caso: Paciente do sexo feminino, 13 anos, procurou atendimento médico com urticária crônica e dores epigástricas sem resposta ao tratamento medicamentoso. Os exames solicitados para investigação complementar apresentaram-se normais, exceto a endoscopia digestiva alta com biópsia, que evidenciou gastrite crônica ativa moderada associada ao Helicobacter pylori. Foi iniciado o tratamento adequado para a bactéria em questão e a paciente apresentou remissão dos sintomas. Nova endoscopia digestiva alta para controlar o tratamento após nove meses estava normal. Cinco anos depois, a paciente procurou novamente o ambulatório queixando-se de retorno do quadro de urticária e dores epigástricas. Ela se encontrava em uso de anti-histamínico, sem melhora. Foi novamente submetida a protocolo de exames para investigar urticária crônica, com resultados dentro da normalidade. Foi submetida à endoscopia digestiva alta, que apresentou teste da urease positivo. Iniciou-se então novo tratamento para Helicobacter pylori por sete dias, com desaparecimento da urticária crônica e das dores epigástricas.Comentários: O c...

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Section: Discussionmentioning

confidence: 99%