Chronic Urticaria

Weller, Karsten; Maurer, Marcus

doi:10.1002/9781118357606.ch29

Cited by 1 publication

(1 citation statement)

References 107 publications

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“…The disease activity of all chronic urticaria subtypes can markedly change over time and differ between individual patients. 4 The condition tends to be more common in adults than in children and in females than in males, with peak occurrence in the third to fifth decades of life. This condition is marked by the onset of pruritic wheals, which represent wellcircumscribed areas of non-pitting oedema with blanched centres and raised borders that involve only the superficial portions of the dermis and are seen in conjunction with surrounding erythema of the skin.…”

Section: Introductionmentioning

confidence: 99%

The Role of Infection and Autoimmunity in Urticaria and Angioedema as a Common Entity

Rudenko¹

2021

EMJ Allergy Immunol

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Chronic spontaneous urticaria with angioedema is prevalent, affecting approximately 1% of the general population, and has a significant impact on quality of life, according to epidemiological data. This article aims to broaden the view on the mechanisms of urticaria and the role of infection in the current environment. It is not easy to identify the cause of urticaria but appropriate steps to treat an underlying infection can, in some cases, improve the symptoms of urticaria and angioedema, reduce severity and duration, or lead to remission. Although chronic spontaneous urticaria with angioedema is a multifactorial condition involving inflammation, autoimmunity, and coagulation, IgE-mediated autoimmunity, or autoallergy, is thought to play a major role. Every year, more is learnt about the role of cells releasing mediators, underlying autoimmune processes that lead to the development of mast cell activation and urticaria. It has become increasingly clear that mast cell roles in immune system responses are not limited to an allergic role; they are key players in protective immune responses, both innate and adaptive, to various pathogens and in defence of some infections. Several guidelines, consensus papers, and practice parameters have been developed for the management of chronic urticaria. The Dermatology Section of the European Academy of Allergology and Clinical Immunology (EAACI), the Global Allergy and Asthma European Network (GA2LEN), the European Dermatology Forum (EDF), and the World Allergy Organization (WAO) produce a guideline, which is revised every 4 years by a global panel of experts in the field. Infections may be a cause, aggravating factor, or unassociated bystander in chronic urticaria. The author looked at evidence, using a keyword search, for the role of viral and bacterial infections in acute, acute recurrent, and chronic urticaria and angioedema, including COVID-19, herpes, viral hepatitis, and Helicobacter pylori.

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Section: Introductionmentioning

confidence: 99%

The Role of Infection and Autoimmunity in Urticaria and Angioedema as a Common Entity

Rudenko¹

2021

EMJ Allergy Immunol

View full text Add to dashboard Cite

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Chronic Urticaria

Cited by 1 publication

References 107 publications

The Role of Infection and Autoimmunity in Urticaria and Angioedema as a Common Entity

The Role of Infection and Autoimmunity in Urticaria and Angioedema as a Common Entity

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