Urticaria and Angioedema

Wedi, Bettina

doi:10.1007/978-3-662-58713-3_29-1

Cited by 4 publications

(4 citation statements)

References 52 publications

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“…Several risk factors seem to play a role in the incidence of urticaria such as gender, age, nutritional status and history of atopy (Antia et al, 2018;Hon et al, 2019;Wedi, 2020). History of atopy in urticaria patients such as atopic dermatitis, asthma and allergic rhinitis can play a role in the incidence of chronic urticaria (Kim et al, 2017).…”

Section: Discussionmentioning

confidence: 99%

Risk factors of acute and chronic urticaria in dermatology and venereology outpatient clinic Dr. Soetomo General Academic Teaching Hospital, Surabaya, Indonesia

Denissafitri¹,

Umborowati²,

Ervianti³

et al. 2022

ijhs

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Urticaria is a skin disorder characterized by localized redness or edema of the mucosa followed by an itching sensation that subsides within a day. Proper treatment not only requires pharmacological treatment but also preventive measures to reduce the impact of risk factors that can worsen the patient's urticaria complaints. This study is an observational study with a retrospective approach that aims to evaluate the risk factors of acute and chronic urticaria patients at Allergy Immunology Division Dermatovenereology Outpatient Clinic Dr. Soetomo General Academic Teaching Hospital, Surabaya, Indonesia from 2018 to 2020. This study found 179 new urticaria patients with the number of acute urticaria patients 114 patients (63.7%) and chronic urticaria 65 patients (36.3%). The analysis was conducted based on the characteristics of the samples gender, age, atopic history with a p-value>0.05. There was a statistically significant correlation between Body Mass Index (BMI) (p=0.003). The multivariable logistic regression analysis showed BMI (OR=1.16; 95%CI=1.05-1.27; p=0.002) and history of allergic rhinitis (OR=4.32; 95%CI=1.25-14.86; p=0.020) were factors that played a significant role in the incidence of chronic urticaria.

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Section: Discussionmentioning

confidence: 99%

Risk factors of acute and chronic urticaria in dermatology and venereology outpatient clinic Dr. Soetomo General Academic Teaching Hospital, Surabaya, Indonesia

Denissafitri¹,

Umborowati²,

Ervianti³

et al. 2022

ijhs

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“…Urticaria is a frequently seen dermatological disorder distinguished by the manifestation of wheals, angioedema, or a combination thereof [1,2]. The hives are transient, lasting for a short duration ranging from minutes to hours, and resolve without any concurrent secondary cutaneous manifestations, such as scales or excoriations.…”

Section: Introductionmentioning

confidence: 99%

“…The mediators that are released by mast cells generate a localized response that is marked by vasodilation, increased permeability of capillaries, and plasma leakage. This reaction ultimately leads to elevated, red wheals [2]. The stimulation of sensory skin nerves has been identified as the underlying cause for the appearance of itch and the presence of an erythematous halo, which is a direct outcome of the axon reflex [1,2].…”

Section: Introductionmentioning

confidence: 99%

“…This reaction ultimately leads to elevated, red wheals [2]. The stimulation of sensory skin nerves has been identified as the underlying cause for the appearance of itch and the presence of an erythematous halo, which is a direct outcome of the axon reflex [1,2]. Nevertheless, the precise pathophysiological mechanisms responsible for these events have not been wholly understood as of now.…”

Section: Introductionmentioning

confidence: 99%

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Intradermal Immunoglobulin E (IgE) Injection in a Specific Interval With Emollient in the Control of Chronic Idiopathic Urticaria and Allergic Rhinitis

Sumi,

Bhuiyan,

Mukit

et al. 2023

Cureus

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Background and objective: Urticaria is distinguished by the activation of mast cells and basophils via degranulation, predominantly induced by the cross-linkage of allergens with specific immunoglobulin E (IgE) antibodies. Several hypotheses propose that intradermal injections of IgE stimulate the production of antibodies that are specifically targeted towards the histamine/immunoglobulin complex. Subsequently, these antibodies exhibit binding affinity towards and exert inhibitory effects on the generation of histamine during the occurrence of allergic responses. The administration of many histaglobulin injections results in an increase in the concentration of these specific antibodies. Consequently, the present study was devised to assess the effectiveness of intradermal IgE injection in conjunction with an emollient for managing chronic idiopathic urticaria and allergic rhinitis at varying time intervals.Methods: This study employed a cross-sectional design and included a sample of 104 participants. The sample was divided into two groups: persons diagnosed with chronic idiopathic urticaria (n=54) and individuals diagnosed with both allergic rhinitis and chronic urticaria (n=50). A 1 ml intradermal IgE injection was provided on a weekly basis over a duration of six months. A total of 49 patients were treated with intradermal IgE injection alone, while 93 patients were treated with intradermal IgE injection combined with emollient application. The evaluation of the treatment's efficacy involved the utilization of the urticaria activity score (UAS) for chronic urticaria, as well as the assessment of symptomatic improvement in cases of allergic rhinitis. The weekly examination was conducted over a span of three consecutive weeks, followed by subsequent evaluations after four, 12, and 24 weeks of attendance, culminating in the final assessment.Results: Within the sample of 104 participants, a substantial majority of 93 individuals exhibited good outcomes in the management of their condition with the utilization of emollients, whereas a minority of 11 patients experienced inadequate control. In contrast, a group of 49 participants had a therapy regimen that did not include the application of emollients, while another group of 55 persons displayed symptoms that were not effectively managed. Based on recent research findings, a noticeable decrease in symptoms of modest magnitude was observed by the end of the third month. Furthermore, it is important to note that all symptoms were successfully alleviated during a six-month therapeutic regimen, but there was a minor residual dissatisfaction with the impairment of the sense of smell.Conclusion: Following the administration of six intradermal IgE injections, a significant improvement in symptoms was observed in over 97% of patients, regardless of whether their IgE levels remained unaltered, decreased, or rose.

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Ligelizumab for the treatment of chronic spontaneous urticaria

Wedi

2020

Expert Opinion on Biological Therapy

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Urticaria and Angioedema

Cited by 4 publications

References 52 publications

Risk factors of acute and chronic urticaria in dermatology and venereology outpatient clinic Dr. Soetomo General Academic Teaching Hospital, Surabaya, Indonesia

Risk factors of acute and chronic urticaria in dermatology and venereology outpatient clinic Dr. Soetomo General Academic Teaching Hospital, Surabaya, Indonesia

Intradermal Immunoglobulin E (IgE) Injection in a Specific Interval With Emollient in the Control of Chronic Idiopathic Urticaria and Allergic Rhinitis

Ligelizumab for the treatment of chronic spontaneous urticaria

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