Urtica Dioica Root Extract on Clinical and Biochemical Parameters in Patients with Benign Prostatic Hyperplasia, Randomized Controlled Trial

Karami, Ali Akbar; Sheikhsoleimani, Mahsa; Memarzadeh, Mohammad Reza; Haddadi, Elnaz; Bakhshpour, Mohammad; Mohammadi, Navid; Mirhashemi, Seyyed Mehdi

doi:10.3923/pjbs.2020.1338.1344

Cited by 12 publications

(5 citation statements)

References 24 publications

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“…The results revealed that UDE possesses an intermediate effect on IPSS, while there was a small effect on the serum high-sensitivity C-reactive protein (hs-CRP), intermediate to large effect on malondialdehyde (MDA) levels, and intermediate effect on superoxide dismutase (SOD) activity. In addition, there were no unwanted/side effects observed in any subject after consumption of UDE for 3 months period among BPH patients, which could be beneficial [74].…”

Section: Clinical Studies On Urtica Dioicamentioning

confidence: 72%

Stinging Nettle (Urtica dioica L.): Nutritional Composition, Bioactive Compounds, and Food Functional Properties

et al. 2022

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Stinging nettle (Urtica dioica L., Urticaceae) is commonly found in Asia, Africa, and Europe and has a long history of being used as food and traditional medicine. Recently, this plant is gaining attention as a highly nutritious food, where fresh leaves are dried and used as powder or in other forms. Leaves are rich in many bioactive compounds. This review aims to cover the traditional uses in food and medicine, as well as its nutritional composition, including its bioactive chemical constituents and reported food functional activities. Various bioactive chemical constituents have been isolated from stinging nettle to date, such as flavonoids, phenolic acids, amino acid, carotenoids, and fatty acids. Stinging nettle extracts and its compounds, such as rutin, kaempferol, and vitamin A, are also used for their nutritional properties and as anti-inflammatory and antioxidant agents. Future studies should focus on the proper formulation and stability testing of the functional foods containing stinging nettle and their detailed activities in clinical studies.

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Section: Clinical Studies On Urtica Dioicamentioning

confidence: 72%

Stinging Nettle (Urtica dioica L.): Nutritional Composition, Bioactive Compounds, and Food Functional Properties

et al. 2022

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“…The anti-inflammatory activity of UD has long been studied and its effectiveness has been confirmed in various settings, including in vitro, in vivo, and (1a,2b,5a,6a)-(9CI) Wichtl 1986, 1987;Kraus and Spiteller 1991;Mamta and Preeti 2014) through limited clinical trials. Traditional medicine has also proved to act directly or indirectly in managing diseases with inflammatory background (Klingelhoefer et al 1999;Riehemann et al 1999;Broer and Behnke 2002;Konrad et al 2005;Toldy et al 2005Toldy et al , 2009Criado et al 2006;Roschek et al 2009;Denzler et al 2010;Namazi et al 2011Namazi et al , 2022Genc et al 2011;Vafaee et al 2012;Hajhashemi and Klooshani 2013;Oguz et al 2013;Johnson et al 2013;Dar et al 2013;Yilmaz et al 2014;Daneshmand et al 2016;Kaya et al 2016;Patel et al 2016Patel et al , 2018Zemmouri et al 2017;Bisht et al 2017;Pigat et al 2019;Karami et al 2020;Saponaro et al 2020;Kasouni et al 2021;Shahzad et al 2021;Mannila et al 2022).…”

Section: Anti-inflammatory Potentialmentioning

confidence: 99%

Comprehensive review of Urtica dioica L. (Urticaceae) phytochemistry and anti-inflammatory properties

Parente,

Paiva-Santos,

Cabral

et al. 2024

Phytochem Rev

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Herbal medicinal products are widely considered beneficial and gaining importance in preventing and treating several diseases. Urtica dioica L. (UD) is a medicinal plant that has been used as an herbal remedy and dietary supplement for centuries based on traditional experience or random trials without the know-how of phytoconstituents. UD is one of those herbs with a long record of anti-inflammatory activity and several mechanisms of action have been discussed. Plant part, extraction solvent, and phytoconstituents have a determinant effect on both efficacy and therapeutic objective. Current literature mainly elaborates on the antioxidant effect of Urtica species, with the anti-inflammatory role of UD still being a matter of discussion, as in vitro and in vivo studies have only been characterized to such an extent. In order to elaborate on this topic, the present review aims to characterize the anti-inflammatory action of several UD extracts according to in vitro and in vivo results, as well as the possible molecules and respective mechanism responsible for its anti-inflammatory effect on several pathologies. Despite the knowledge gathered so far surrounding the anti-inflammatory activity of UD, further studies are required to characterize the mechanism of action and discriminate between the molecules underlying the beneficial effects of nettle on inflammatory diseases.

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“…In 2020, Karami et al reported a randomized controlled trial investigating the efficacy of stinging nettle root extract in 30 LUTS/BPH patients (administered 450 mg tablet extract per day for 12 weeks) and in 30 men that served as controls (placebo group) [ 184 ]. The measured parameters were IPSS, C-reactive protein levels, malondialdehyde (MDA), and SOD activities.…”

Section: Nutraceutical Therapies For Bphmentioning

confidence: 99%

“…The measured parameters were IPSS, C-reactive protein levels, malondialdehyde (MDA), and SOD activities. The results revealed immediate effects (within days) in improving IPSS values, a small effect on C-reactive protein, intermediate effects on MDA and SOD activities, without any adverse effects after 3 months of stinging nettle on the oral supplementation treatment [ 184 ].…”

Section: Nutraceutical Therapies For Bphmentioning

confidence: 99%

Overview of BPH: Symptom Relief with Dietary Polyphenols, Vitamins and Phytochemicals by Nutraceutical Supplements with Implications to the Prostate Microbiome

Stewart

Lephart

2023

IJMS

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Benign prostatic hyperplasia (BPH) is an age-related disorder, which is one of the most prevalent and costly benign neoplasms in men with over 94 million cases worldwide. Starting before or around 50 years of age, there is a linear increase in prostate volume and BPH symptoms, which are influenced by changes in hormonal, inflammatory, growth factors, cell receptor signaling, diet, physical activity, and the microbiome of the prostate that leads to cellular proliferation. While current pharmaceutical or surgical treatments are currently available, each treatment has serious side effects. This dilemma has motived men to seek treatment without negative side effects from medicinal plants such as botanicals, phytochemicals, and vitamins that have established safety records. This narrative overview focuses on several botanicals, phytochemicals and vitamins that are widely used in the treatment of BPH and emphasizes how, in some cases, combinations of these natural ingredients may provide better BPH symptom relief compared to utilization of a single medicinal plant product (monotherapy). Finally, this overview highlights in vitro, in vivo animal studies and mainly clinical data of journal reports published in the past 5 years from January 2018 to January 2023 on BPH and nutraceuticals. Notably, there is an evolving perspective or rethinking of the role that medicinal phytochemicals and natural vitamins usage play; that is, they may hold promise or are likely to alleviate BPH symptoms.

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Urtica Dioica Root Extract on Clinical and Biochemical Parameters in Patients with Benign Prostatic Hyperplasia, Randomized Controlled Trial

Cited by 12 publications

References 24 publications

Stinging Nettle (Urtica dioica L.): Nutritional Composition, Bioactive Compounds, and Food Functional Properties

Stinging Nettle (Urtica dioica L.): Nutritional Composition, Bioactive Compounds, and Food Functional Properties

Comprehensive review of Urtica dioica L. (Urticaceae) phytochemistry and anti-inflammatory properties

Overview of BPH: Symptom Relief with Dietary Polyphenols, Vitamins and Phytochemicals by Nutraceutical Supplements with Implications to the Prostate Microbiome

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