Ursolic acid from Agastache mexicana aerial parts produces antinociceptive activity involving TRPV1 receptors, cGMP and a serotonergic synergism

Antifungal activity of essential oils extracted from Agastache mexicana ssp. xolocotziana and Porophyllum linaria against post-harvest pathogens

“…The Mexican endemic Agastache mexicana (Lamiacea) is an aromatic medicinal herb used in traditional medicine as a tranquilizer, sleep inducer, anti-hypertensive, rheumatism treatment, and treatment for stomach pain (Estrada-Reyes et al, 2014;Linares et al, 1995;Hernández-Abreu et al, 2013;Verano et al, 2013;Gonzalezhttp://dx.doi.org/10.1016Gonzalezhttp://dx.doi.org/10. /j.indcrop.2015.058 0926-6690/© 2015 Elsevier B.V. All rights reserved.…”

“…Trujano et al, 2012;Ibarra-Alvarado et al, 2010;Argueta et al, 1994). Studies have reported the isolation of chemical compounds from this plant including diosmetin, gardenin A, acacetin, ursolic acid, and tilianin (Estrada-Reyes et al, 2014;Verano et al, 2013;Hernandez-Abreu et al, 2011), and the main constituents of its essential oil were are pulegone (75%), menthone (14%), and limonene (3%) (Svoboda et al, 1995).…”

Antinociceptive Activity of Borreria verticillata: In vivo and In silico Studies

“…Because UA has exhibited this feature (multi-targets), it may be considered an advantage over other compounds described in the literature. Verano et al (2013) has shown that UA 10 mg/kg (i.p) has an antinociceptive effect, so we chose this dose to test its effect orally and have confirmed the antinociceptive and anti-inflammatory effects of UA through inhibitions of the TRPV1 receptor and serotonergic synergism (5-HT); reduced IL-2, IL-6, interferon (IFN)-γ, TNF-α, reactive oxygen species (ROS), phospholipase A2 and NF-κβ release; reduced COX-2 and inducible nitric oxide synthase (iNOS) expression; (Kashyap et al, 2016) and favorable interactions for complexes formed with COX-1 and COX-2 (Magalhães et al, 2012). Zhang et al (2013) demonstrated that UA can induce apoptosis of cancer cells by reducing COX-2 expression and Ma et al (2014) demonstrated that UA reduced COX-2 expression in CCl 4 -treated animals.…”

The effect of hydroalcoholic extract of Urtica dioica on morphine withdrawal signs in male mice

“…This links the effects of flavonoids to their effects on the GABAergic system (31,32). In addition to the quercetin, ursolic acid has shown different pharmacological effects in rodents including neuroprotective, antidepressant-like effect, antinociceptive and anxiolytic effects (33)(34)(35). On the other hand, Taviano et al demonstrated that ursolic acid isolated from Nepta sibthorpii inhibited the acetic acidinduced abdominal constriction.…”