Ursolic acid and its natural derivative corosolic acid suppress the proliferation of APC-mutated colon cancer cells through promotion of β-catenin degradation

Anti-cancer effect of ursolic acid activates apoptosis through ROCK/PTEN mediated mitochondrial translocation of cofilin-1 in prostate cancer

“…The present study observed that ursolic acid significantly suppressed cell growth, and induced apoptosis and caspase-3 and caspase-9 activity in DU145 cells. Previous studies have revealed that ursolic acid is able to suppress cell proliferation and induce apoptosis of APC-mutated colon cancer cells (22), U937 cells (23) and colon cancer-initiating cells (24). A current focus of cancer research concerns the development of medicines to promote cell apoptosis.…”

A map describing the association between effective components of traditional Chinese medicine and signaling pathways in cancer cells in vitro and in vivo

“…Ursolic acid was proved to suppress the proliferation of colon cancer cell line HEK293 by promoting degradation of β-catenin (33). In Enrlich ascites carcinoma cell line, ursolic acid acts as an inducer of apoptosis through the mitochondrial signaling pathway in intro and in vivo (34), and in T24 human bladder cancer cells, it induces apoptosis via the Akt/ NF-κB pathway (35).…”

Ellagic acid regulates Wnt/β-catenin signaling pathway and CDK8 in HCT 116 and HT 29 colon cancer cells

“…Studies have demonstrated that phytochemicals are effective in modulating Wnt/ -catenin signalling pathway (Zhang, et al, 2013;Kim et al, 2014). Ellagic acid, a dimeric derivative of gallic acid occurs naturally in fruits as-strawberry, raspberry, pomegranate, grapes and blackberries and in nuts (Thresiamma and Kuttan, 1996;Talcott and Lee, 2002;Mullen et al, 2003).…”

“…Genetic defects triggering aberrant activation of Wnt/ -catenin signalling are common and are reported in over 90% of sporadic cases of colon cancer (Miyaki et al, 1994;Clevers, 2006;Klaus and Birchmeier, 2008;Schon et al, 2014). The key effecttor of Wnt/ -catenin signaling pathway is -catenin that upon activation of Wnt signal, translocates into the nuclear region forming a ternary complex with transcription factors-TCF/Lef (T-cell factor, lymphoid enhancer factor) and activates genes involved in cell pro- Studies have demonstrated that phytochemicals are effective in modulating Wnt/ -catenin signalling pathway (Zhang, et al, 2013;Kim et al, 2014). Ellagic acid, a dimeric derivative of gallic acid occurs naturally in fruits as-strawberry, raspberry, pomegranate, grapes and blackberries and in nuts (Thresiamma and Kuttan, 1996;Talcott and Lee, 2002;Mullen et al, 2003).…”