Urothelial Tumors and Dual-Band Imaging: A New Concept in Confocal Laser Endomicroscopy

Marien, Arnaud; Röck, Andrea; Maadarani, K. El; Francois, Catherine; Gosset, Pierre; Mauroy, Brigitte; Bonnal, J

doi:10.1089/end.2016.0892

Cited by 17 publications

(9 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Combination of CLE with other endoscopic techniques could be a better choice and may greatly alter current bladder cancer management. Marien et al [28] evaluated the feasibility of using CLE with 2 fluorophores (fluorescein and hexyl aminolevulinate) for bladder cancer diagnosis and found that sensitivity and specificity of this combination can reach 80 and 100%, respectively. However, application of CLE combined with other endoscopic techniques is still in the early stages, and the advantage of various combinations remains to be further investigated.…”

Section: Discussionmentioning

confidence: 99%

Diagnostic Performance of Confocal Laser Endomicroscopy for the Detection of Bladder Cancer: Systematic Review and Meta-Analysis

Wang

Luo

et al. 2020

Urol Int

View full text Add to dashboard Cite

Objective: To systematically evaluate the diagnostic efficacy of confocal laser endomicroscopy (CLE) in detection of bladder cancer. Methods: A systematic literature search on CLE in diagnosing bladder cancer in PubMed, Embase, and the Cochrane Library databases was performed. A bivariate meta-regression model was used for meta-analysis to evaluate the pooled diagnostic value of CLE. Results: A total of 5 eligible studies involving 302 lesions were available for this meta-analysis. In a per-lesion analysis, pooled sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic odds ratio (DOR), and summary receiver-operating curve (SROC) area under the curve (AUC) of CLE for malignant lesions were 0.90 (95% confidence interval [

show abstract

Section: Discussionmentioning

confidence: 99%

Diagnostic Performance of Confocal Laser Endomicroscopy for the Detection of Bladder Cancer: Systematic Review and Meta-Analysis

Wang

Luo

et al. 2020

Urol Int

View full text Add to dashboard Cite

show abstract

“…Five experiments in four studies reported a sensitivity of more than 90%. Only the study of Marien et al [21] reported sensitivity below 80%. We conducted a pooling effect estimate using Mosses-Litenberg's Bivariate Model and found a pooled sensitivity of 90.2% (0.86, 0.93).…”

Section: Cle Accuracy In Differentiating Malignant and Benign Tumorsmentioning

confidence: 98%

The Accuracy of Confocal Laser Endomicroscopy in Diagnosing Bladder Cancer: A Systematic Review & Meta-Analyses

Hafizar

Myh

2021

Indonesian Journal of Cancer

View full text Add to dashboard Cite

Background: Multiple advancements of endoscopic technology were designed to enhance the sensitivity and specificity of the diagnostic tools of bladder cancer; thus, we perform a meta-analysis to compare diagnostic performance between confocal laser endomicroscopy (CLE) and biopsy for detecting bladder cancer.Methods: We compared CLE’s accuracy in diagnosing bladder cancer reported by studies obtained from the electronic database MEDLINE, CENTRAL, and CINAHL, from May to June 2020. The pooled effect estimate was calculated employing the DerSimonian and Laird random-effects model. We only included moderate to high-quality studies, which had been assessed by the QUADAS-2 tool.Results: Eight studies were included in this review; five of those were good-quality studies. A total of 519 samples from 345 patients were included in the pooled effect estimate calculation. Pooled sensitivity and specificity of CLE in diagnosing bladder cancer were 90.2% (0.86, 0.93) and 78.1% (0.71, 0.85), respectively. The use of white-light cystoscopy (WLC) before CLE increased its specificity (56.8% versus 84.6%). Pooled sensitivity and specificity of CLE in predicting lowgrade lesion were 73% (0.66, 0.80) dan 83% (0.78, 0.87), respectively. Meanwhile, pooled sensitivity and specificity of CLE in predicting high-grade lesion were 73% (0.66, 0.78) and 79% (0.73, 0.83), respectively.Conclusions: CLE has good accuracy in distinguishing malignant and benign tumors. Grading tumors with this modality is also accurate. The use of probe CLE (pCLE), coupled with WLC, will increase its specificity.

show abstract

“…Recent meta-analysis showed that combination of OCT with florescence imaging technologies such as BLC could further improve its diagnostic accuracy and avoid unnecessary biopsies (23). The results of ex vivo study of combining OCT and BLC, however, had been disappointing as HAL cannot provide a clear cellular architecture due to due to cytoplasmic localization (24). It has been suggested that combination of RS and molecular targeting nanoparticles, referred to as surface-enhanced RS, can significantly improve sensitivity and specificity for detection of bladder tumors through signal amplification and molecular mapping (4).…”

Section: Combination With Other Enhanced Imaging Techniquesmentioning

confidence: 99%

Multiparametric cystoscopy: is the future here yet?

Ahmadi¹,

Daneshmand²

2021

Transl Androl Urol

View full text Add to dashboard Cite

Urothelial Tumors and Dual-Band Imaging: A New Concept in Confocal Laser Endomicroscopy

Cited by 17 publications

References 15 publications

Diagnostic Performance of Confocal Laser Endomicroscopy for the Detection of Bladder Cancer: Systematic Review and Meta-Analysis

Diagnostic Performance of Confocal Laser Endomicroscopy for the Detection of Bladder Cancer: Systematic Review and Meta-Analysis

The Accuracy of Confocal Laser Endomicroscopy in Diagnosing Bladder Cancer: A Systematic Review & Meta-Analyses

Multiparametric cystoscopy: is the future here yet?

Contact Info

Product

Resources

About