Transurethral Resection of the Prostate (TURP) pada pasien Benign Prostatic Hyperplasia (BPH) dengan indikasi absolut operasi. menggunakan suatu cairan irigasi. Cairan irigasi tersebut dapat masuk ke sirkulasi yang menimbulkan suatu kondisi intoksikasi air. Kelebihan cairan, yang terserap karena proses operasi TURP, dapat menyebabkan terjadinya hiponatremia akut, kejadian ini disebut sindroma TURP. Terjadinya sindroma TURP memang tergolong jarang, tetapi sindroma TURP memiliki komplikasi yang bahkan dapat menyebabkan kematian. Tujuan penelitian ini adalah menentukan korelasi lama operasi terhadap perubahan kadar natrium pasca operasi TURP di RSUP Dr. M. Djamil Padang. Penelitian ini merupakan studi analitik observasional dengan rancangan potong lintang. Pengambilan sampel dilakukan dengan teknik consecutive sampling. Sampel penelitian berjumlah dua puluh sampel yang diambil dari rekam medis pasien BPH yang melakukan TURP di RSUP Dr. M. Djamil Padang sesuai kriteria inklusi. Analisis data menggunakan uji korelasi Pearson. Hasil penelitian menunjukkan rerata lama operasi TURP adalah 63,25 ± 18,59 menit dan rerata perubahan kadar natrium adalah 5,0 ± 3,4 mEq/L. Uji korelasi Pearson menunjukan terdapatnya hubungan tidak bermakna antara lama operasi terhadap perubahan kadar natrium pasca operasi TURP dengan korelasi sangat lemah positif (r=0,141, p=0,552). Disimpulkan bahwa terdapat adanya korelasi sangat lemah dengan hubungan yang tidak bermakna antara lama operasi terhadap perubahan kadar natrium pasca operasi TURP di RSUP Dr. M. Djamil Padang.
Latar Belakang: Sepsis didefinisikan sebagai disfungsi organ yang disebabkan kegagalan homeostatis oleh respons tubuh yang tidak teratur dalam menghadapi infeksi sehingga mengancam jiwa. Hal ini menjadi ancaman diakibatkan angka harapan hidup bertambah sehingga terjadi peningkatan komorbiditas. Urosepsis adalah sepsis yang terjadi akibat infeksi pada urogenital, berupa respons inflamasi sistemik yang merupakan sekuele dari infeksi pada traktus urinarius, sering terjadi sebagai komplikasi lanjutan obstruksi, tumor saluran kemih, maupun stenosis dari saluran kemih juga pada tindakan invasif. Objektif: Kajian ini dilakukan untuk mengetahui tatalaksana dari kasus urosepsis. Metode: Penelitian ini merupakan tinjauan literatur sistematis. Pencarian dilakukan melalui empat pangkalan data, yaitu Pubmed, ScienceDirect, The Cochrane Central Register of Controlled Trials (CENTRAL), dan Turning Research Into Practice (TRIP). Masing-masing dari hasil penemuan diseleksi berdasarkan kriteria inklusi dan eksklusi diikuti pedoman Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA), yang disintesis dalam bentuk matriks data, yang sebelumnya telah dilakukan telaah kritis. Hasil: Terdapat 18 jurnal artikel/studi kualitatif maupun kuantitatif yang termasuk dalam tinjauan literatur sistematis ini. Ditemukan bakteri patogen yang paling umum mendasari kasus urosepsis adalah bakteri gram negatif. Berdasarkan kegiatan tinjauan literatur sistematis, tatalaksana urosepsis memiliki tiga konsep pengobatan, yaitu terapi penggunaan antimikroba, terapi eliminasi serta spesifik, serta terapi tambahan. Kesimpulan: Tatalaksana urosepsis sendiri masih terus berkembang dari tahun ke tahun, sehingga diperlukan penelitian lebih lanjut terutama pada studi dengan sifat kualitatif.
Increased PSA levels can be caused by prostate cancer, prostate infection, and BPH. Several studies report that the use of antibiotics can affect PSA levels. This study aims to determine the effect of ciprofloxacin administration in patients with prostate-specific antigen values ??of 4-10 ng/mL. This was an analytical study with a prospective cohort design. This study was conducted at Dr. M. Djamil Hospital, Padang starting from July 2022 until October 2022. The sampling technique used non-probability sampling with consecutive sampling method. The patient was given the antibiotic ciprofloxacin 2x500 mg for 2 weeks. PSA measurements were carried out before and after administration of antibiotics. There were 20 subject with an average age of 62.65 years (52-79). The mean of initial PSA value was 6.53 ng/mL and the final PSA value was 5.76 ng/mL. There was a significant difference between PSA levels before and after administration of ciprofloxacin (p=0.000). The use of antibiotics in patients with PSA levels of 4-10 ng/ml can reduce PSA levels.
Background: Multiple advancements of endoscopic technology were designed to enhance the sensitivity and specificity of the diagnostic tools of bladder cancer; thus, we perform a meta-analysis to compare diagnostic performance between confocal laser endomicroscopy (CLE) and biopsy for detecting bladder cancer.Methods: We compared CLE’s accuracy in diagnosing bladder cancer reported by studies obtained from the electronic database MEDLINE, CENTRAL, and CINAHL, from May to June 2020. The pooled effect estimate was calculated employing the DerSimonian and Laird random-effects model. We only included moderate to high-quality studies, which had been assessed by the QUADAS-2 tool.Results: Eight studies were included in this review; five of those were good-quality studies. A total of 519 samples from 345 patients were included in the pooled effect estimate calculation. Pooled sensitivity and specificity of CLE in diagnosing bladder cancer were 90.2% (0.86, 0.93) and 78.1% (0.71, 0.85), respectively. The use of white-light cystoscopy (WLC) before CLE increased its specificity (56.8% versus 84.6%). Pooled sensitivity and specificity of CLE in predicting lowgrade lesion were 73% (0.66, 0.80) dan 83% (0.78, 0.87), respectively. Meanwhile, pooled sensitivity and specificity of CLE in predicting high-grade lesion were 73% (0.66, 0.78) and 79% (0.73, 0.83), respectively.Conclusions: CLE has good accuracy in distinguishing malignant and benign tumors. Grading tumors with this modality is also accurate. The use of probe CLE (pCLE), coupled with WLC, will increase its specificity.
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