Urothelial (Transitional Cell) Carcinoma Arising in Mature Cystic Teratoma - A Case Report -

Abstract

Mature cystic teratoma (MCT) is one of the most common benign ovarian tumors, but 1-2% of MCTs are transformed to a malignant neoplasm. Urothelial carcinoma (UC) or transitional cell carcinoma is the most common cancer in the urinary tract. However, UC is a very rare component of transformed malignancy of MCT. Here we report a case of UC arising in an MCT in a 52-year-old woman. Grossly, the ovary was partly cystic and partly solid. Microscopically, the cyst revealed the classic features of MCT and the solid area was papillary UC. By immunohistochemistry using cytokeratins and thrombomodulin, the UC showed a similar expression to that of UC arising in the urinary tract, rather than resembling a primary transitional cell carcinoma of the ovary. When UC is found in a component of MCT, the origin of the carcinoma should be evaluated and urinary tract examinations are required to rule out metastasis.

A rare case of urothelial carcinoma arising in mature cystic teratoma

“…Malignant transformation is rare and is generally seen in postmenopausal age group. 2 The incidence of malignant transformation is 1-2%. 1,2 Squamous cell carcinoma is most common malignant transformation and accounts for 80% of the cases.…”

“…2 The incidence of malignant transformation is 1-2%. 1,2 Squamous cell carcinoma is most common malignant transformation and accounts for 80% of the cases. 2 Historically these tumors are diagnosed postoperatively and are often present as an incidental finding histologically.…”

“…Mature cystic teratoma (MCT) is a common benign adnexal tumour in females in the reproductive age group. 1,2 Malignant transformation in mature cystic teratoma of the ovary is rare, occurring in only 1-2% of cases. 1,2 The most common malignancy is squamous cell carcinoma, which consists of about 80% of malignant transformations.…”

“…1,2 Malignant transformation in mature cystic teratoma of the ovary is rare, occurring in only 1-2% of cases. 1,2 The most common malignancy is squamous cell carcinoma, which consists of about 80% of malignant transformations. 1 Urothelial carcinoma in mature cystic teratoma is very rare and occurs in 1-2% of cases.…”

“…1 Urothelial carcinoma in mature cystic teratoma is very rare and occurs in 1-2% of cases. 2 The most common presentation in malignant transformation of mature cystic teratoma is increased abdominal girth associated with or without abdominal pain. 3…”