Urothelial carcinoma arising from an ovarian mature cystic teratoma

Chuang, Hui‐Yu; Chen, Yi-Ting; Mac, Tak-Loi; Chen, Yu-Chieh; Chen, Hung-Sheng; Wang, Wanshan; Tsai, Eing‐Mei

doi:10.1016/j.tjog.2015.06.003

Cited by 12 publications

(17 citation statements)

References 6 publications

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“…Due to the different components of a teratoma, there can be various malignant transformations, such as squamous cell carcinomas (75%-80%), adenocarcinomas (7%), sarcomas (7%), basal cell carcinomas, sebaceous gland carcinomas, malignant melanomas, small cell lung cancers, transitional cell carcinomas, clear cell carcinomas, and gliomas [1,[3][4][5][6] . The patholog-ical diagnosis confirmed that this case was a teratoma accompanied by the malignant transformation of a sebaceous gland carcinoma, which is very rare.…”

Section: Discussionmentioning

confidence: 99%

“…An enhanced CT and MRI show higher resolution of the soft tissue and higher sensitivity to fat composition and calcification, but it is still difficult to predict the malignant transformation of a teratoma by CT and MRI scanning because of its complex tissue composition. When an enhanced CT or MRI shows a tumor diameter of ≥ 10 cm, cystic wall thickening, an unclear boundary, irregular lobulation, uneven solid component enhancement, transmural necrosis, surrounding tissue adhesion, and lymph node enlargement in the peritoneum, these symptoms indicate the possibility of invasive disease [5,11,12] . When compared with the traditional T1-weighted images, the fat-suppressed T1-weighted images show more clearly the contrast-enhanced solid part of the teratoma, which is helpful to predict the teratoma malignancy [7] .…”

Section: Discussionmentioning

confidence: 99%

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Malignant Transformation of a Mature Ovarian Teratoma: A Case Report and Review of the Literature

Zhou

Jin

et al. 2018

Clin Surg Res Commun

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A mature ovarian teratoma is a common benign germ cell tumor of the ovary in women that rarely causes a malignant transformation. However, a malignant transformation can occur in the ectodermal, mesodermal, and endodermal tissues of the tumor. A squamous cell carcinoma is the most common and an adenocarcinoma is the second most common malignant tumor derived from a cystic teratoma. Due to the rarity of malignant transformations in mature teratomas and the lack of clinical data, the clinical pathological features, malignant transformation mechanism, therapeutic methods, and prognosis-relevant factors are unclear. Currently, there is no specific diagnostic method, and it is a difficult lesion to diagnose before performing surgery. In order to improve clinicians' understanding of a malignant-transformed mature teratoma and identification of malignant-transformed teratomas at early stages, we have reported a case of a mature teratoma with the malignant transformation of a sebaceous gland carcinoma in the Yiwu Central Hospital in Zhejiang, China on May 31, 2018. A review of the literature is also presented to summarize the clinical symptoms, pathogenesis, diagnosis, and treatment of malignant-transformed mature teratomas.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Malignant Transformation of a Mature Ovarian Teratoma: A Case Report and Review of the Literature

Zhou

Jin

et al. 2018

Clin Surg Res Commun

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“…Mature cystic teratoma (MCT) is a common benign adnexal tumour in females in the reproductive age group. 1,2 Malignant transformation in mature cystic teratoma of the ovary is rare, occurring in only 1-2% of cases. 1,2 The most common malignancy is squamous cell carcinoma, which consists of about 80% of malignant transformations.…”

Section: Introductionmentioning

confidence: 99%

“…1,2 Malignant transformation in mature cystic teratoma of the ovary is rare, occurring in only 1-2% of cases. 1,2 The most common malignancy is squamous cell carcinoma, which consists of about 80% of malignant transformations. 1 Urothelial carcinoma in mature cystic teratoma is very rare and occurs in 1-2% of cases.…”

Section: Introductionmentioning

confidence: 99%

“…1,2 The most common malignancy is squamous cell carcinoma, which consists of about 80% of malignant transformations. 1 Urothelial carcinoma in mature cystic teratoma is very rare and occurs in 1-2% of cases. 2 The most common presentation in malignant transformation of mature cystic teratoma is increased abdominal girth associated with or without abdominal pain.…”

Section: Introductionmentioning

confidence: 99%

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A rare case of urothelial carcinoma arising in mature cystic teratoma

Maurya¹,

Bhavsar²

2018

Int J Reprod Contracept Obstet Gynecol

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Mature cystic teratoma is a common benign adnexal tumour in females. It is composed of all the three germ layers (mesoderm, endoderm and ectoderm). Malignant transformation in a mature cystic teratoma of the ovary is rare, occurring in only 1-2% of cases. The most common malignancy is squamous cell carcinoma, which consists of about 80% of malignant transformations. Here we report malignant transformation of MCT in a 74year old post-menopausal female. Grossly the ovary was large cystic occupying the entire abdomen. Trial dissection was done and only 50% of the mass could be dissected due to gross adhesions. HPE reported as urothelial carcinoma in mature cystic teratoma. MCT is easily diagnosed via sonography, but malignant transformation is difficult to identify before surgery. For patients with malignant transformation, squamous cell carcinoma is the most common malignancy arising from MCT, and accounts for 80% of all cases. Other malignancies, such as adenocarcinomas, sarcomas or malignant melanomas have been reported; however, urothelial carcinoma arising from MCT is rare.

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