Urothelial cell carcinoma after BK polyomavirus infection in kidney transplant recipients: A cohort study of veterans

Rogers, Ralph; Gohh, Reginald; Noska, Amanda

doi:10.1111/tid.12752

Cited by 18 publications

(16 citation statements)

References 38 publications

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“…KT recipients are at an increased risk for urothelial carcinoma. [4][5][6][7][8] Infection with oncogenic viruses could be a plausible explanation.…”

Section: Introductionmentioning

confidence: 99%

“…3KT recipients are at an increased risk for urothelial carcinoma. [4][5][6][7][8] Infection with oncogenic viruses could be a plausible explanation.Based on experimental models, JCV inoculation in cells that do not support viral replication leads to cancer formation. 9 Thus, human polyomaviruses have recently been categorized as "possible carcinogens" by the International Agency for Research in Cancer, 10 although a role for JCV in human cancers is not yet proved.…”

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confidence: 99%

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High-grade urothelial carcinoma in a kidney transplant recipient after JC virus nephropathy: The first evidence of JC virus as a potential oncovirus in bladder cancer

Querido

Fernandes

Weigert

et al. 2020

American Journal of Transplantation

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Kidney transplant (KT) recipients have an increased risk for urothelial carcinoma. A role for JC virus (JCV) in human cancers is not yet proved but there is an increasingly reported association between BK virus (BKV) nephropathy and renourinary neoplasms. We report a KT recipient who developed a high‐grade urothelial carcinoma 5 years after a diagnosis of JCV nephropathy and 9 years after kidney transplantation. Neoplastic tissue was positive for JCV DNA by real‐time polymerase chain reaction (PCR). Immunochemical staining showed strong positivity for cell cycle markers (p16, p53, and Ki67) and for early viral protein JCV large T antigen (JCV LTag; using a broad polyomavirus antibody); however, late viral protein (VP1) stained negative. In contrast, in non‐neoplastic urothelium, JCV DNA and all immunochemical markers were negative. These facts suggest that malignancy was induced by JCV. To the best of our knowledge, this is the first report of urothelial high‐grade carcinoma associated with JCV nephropathy in a KT recipient.

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“…KT recipients are at an increased risk for urothelial carcinoma. [4][5][6][7][8] Infection with oncogenic viruses could be a plausible explanation.…”

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

High-grade urothelial carcinoma in a kidney transplant recipient after JC virus nephropathy: The first evidence of JC virus as a potential oncovirus in bladder cancer

Querido

Fernandes

Weigert

et al. 2020

American Journal of Transplantation

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“…Additional risk factors in the recipient could include the effects of immunosuppression 38 as well as a consequence of BK viral infection. 39 The first patient underwent an ABO incompatible living unrelated transplant, with desensitisation protocol (mainly plasmapheresis), in the early stage. The second recipient had a triple regimen immunosuppression, following an early acute rejection episode and she developed also BKV infection, another important risk factor for UC.…”

Section: Discussionmentioning

confidence: 99%

Urothelial carcinoma arising from the transplanted kidney: A single‐center experience and literature review

Bellini

Gopal

Hill

et al. 2019

Clinical Transplantation

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Urothelial carcinoma (UC) is a malignancy predominantly arising in the bladder. Upper tract UC (UUC) is uncommon, accounting only for 5-10% of the cases. High incidence of neoplasms is associated with immunosuppressive therapy; thus, UCs of the transplanted grafts often lead to a more aggressive treatment, in order to withdraw completely the immunosuppression. It significantly affects the patient quality of life, meaning return to dialysis, along with the worse life expectancy. We present our single-institution experience of this rare malignancy in two mid-age kidney transplant recipients, with UCs successfully treated with radical nephroureterectomy: G3 pT3 N0 + G3 pT1 N0 in the first patient and G3 pT2 N0 in the second one. We also review the previous literature focusing on stage of presentation and treatment for the affected kidney transplant patients. K E Y W O R D Sgraft nephrectomy, immunosuppression, kidney transplant, malignancy, urothelial carcinoma

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“…Adequately sensitive and specific diagnostics is vital in the assessment of cancer development in infected persons. This became evident to Rogers et al [17] when they examined 646 patients to estimate the relative risk of urinary tract cancer development related to BKPyV infection in patients with kidney transplantation between the year 2000 and 2009. The research results actually confirmed the 8-fold growth of UCC cancer development related to infection, but they were not statistically significant.…”

Section: Bkpyv In Kidney and Urinary Tract Cancermentioning

confidence: 99%

BK Virus in Cancer Development

Pasternak

Kliszczewska

Polz‐Dacewicz

2018

Current Issues in Pharmacy and Medical Sciences

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Polyomavirus (PyV) was discovered by accident in 1950 in the course of describing an infectious factor causing multiple tumours in rodents. The term is derived from two Greek words: poly (many) and oma (tumour). At present the family of human polyomaviruses (HPyV) consists of 10 members. One of the first members was BK virus, isolated in 1971 from the urine of a renal transplant patient. Serological examinations have shown that due to its ability to cause latent infection, about 90% of the general population can have specific antibodies attesting infection. In the case of infected persons with normal immunity, this virus is not dangerous. In the impaired immunity, however, loss of immunity results in virus reactivation and development of many life-threatening illnesses. Serological examinations have also reveal that BK polyomavirus considerably affects the development of cancers in humans. Hence, in 2012 a group of 26 researchers from 11 countries associated with the International Agency for Research on Cancer (a part of the World Health Organisation) classified BK polyomavirus within group 2B - “potentially carcinogenic to humans”

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Urothelial cell carcinoma after BK polyomavirus infection in kidney transplant recipients: A cohort study of veterans

Abstract: In this cohort of KTR veterans, no overall increased or decreased relative risk for malignancy was associated with evidence of prior BKPyV infection. A >8-fold increased risk of developing UCC after BKPyV infection was seen, although this risk was not found to be statistically significant.

Cited by 18 publications

References 38 publications

High-grade urothelial carcinoma in a kidney transplant recipient after JC virus nephropathy: The first evidence of JC virus as a potential oncovirus in bladder cancer

High-grade urothelial carcinoma in a kidney transplant recipient after JC virus nephropathy: The first evidence of JC virus as a potential oncovirus in bladder cancer

Urothelial carcinoma arising from the transplanted kidney: A single‐center experience and literature review

BK Virus in Cancer Development

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