Urothelial carcinoma: variant histology, molecular subtyping, and immunophenotyping significant for treatment outcomes

Takahara, Taishi; Murase, Yota; Tsuzuki, Toyonori

doi:10.1016/j.pathol.2020.09.004

Cited by 22 publications

(21 citation statements)

References 100 publications

(146 reference statements)

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“…Immunophenotyping can reflect the immune status of tumor and its microenvironment, and help to determine the appropriate vaccination for patients [ 17 ]. Here, we analyzed the gene expression landscape of immune-related genes in 294 LIHC samples downloaded from ICGC and 424 LIHC samples from the TCGA database to construct consistent clustering, respectively.…”

Section: Resultsmentioning

confidence: 99%

Identifying Potential Tumor Antigens and Antigens-Related Subtypes in Hepatocellular Carcinoma for mRNA Vaccine Development

Liao

Shi

Tang

et al. 2022

Journal of Oncology

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Background. The mRNA vaccine has become a promising platform for cancer therapy. Lots of studies have been focusing on discovering novel potent cancer-associated antigens to develop mRNA vaccines against cancers. Besides, immunotyping shows the immune status, and immune microenvironment of immunotyping is related with therapeutic reaction. However, potential antigens for mRNA vaccines and immunotyping of liver hepatocellular carcinoma (LIHC) remain far from being understood. Methods. In this study, we collected gene expression data and clinical information data from ICGC and TCGA databases. Using GEPIA2, we calculated differential expression genes and prognostic indices. We applied TIMER to calculate the correlation coefficient between immune infiltrating cells and each gene. Consensus cluster was used for immunotyping of LIHC. Results. We uncovered four most potential candidates including PES1, MCM3, PPM1G, and KPNA2, which were all related with antigen-presenting cell (APC) infiltration and poor survival in LIHC in two independent datasets. Furthermore, three immune-related subtypes (IS1-IS3) of LIHC were identified. All these results were validated in two independent datasets. Furthermore, we validated our results in vitro. Conclusions. The above candidates will be expected to be potential antigen genes for developing anti-LIHC mRNA vaccine, and furthermore, patients with IS2 and IS3 tumors are supposed to be appropriate for mRNA vaccine in LIHC.

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Section: Resultsmentioning

confidence: 99%

Identifying Potential Tumor Antigens and Antigens-Related Subtypes in Hepatocellular Carcinoma for mRNA Vaccine Development

Liao

Shi

Tang

et al. 2022

Journal of Oncology

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“…Urothelial carcinoma has wide histological diversity, and it has been discovered that many variants are associated with poor prognosis and high-grade risk cancer. So, regarding treatment, immune checkpoint inhibitors (ICI) are more popular now in the oncology field than the standard treatment previously [ 37 ].…”

Section: Reviewmentioning

confidence: 99%

Etiologies, Gross Appearance, Histopathological Patterns, Prognosis, and Best Treatments for Subtypes of Renal Carcinoma: An Educational Review

Mohd¹,

Ghannam²,

Mohd³

et al. 2022

Cureus

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Of all primary renal neoplasms, 80-85% are renal cell carcinomas (RCCs), which develop in the renal cortex. There are more than 10 histological and molecular subtypes of the disease, the most frequent of which is clear cell RCC, which also causes most cancer-related deaths. Other renal neoplasms, including urothelial carcinoma, Wilms' tumor, and renal sarcoma, each affect a particular age group and have specific gross and histological features. Due to the genetic susceptibility of each of these malignancies, early mutation discovery is necessary for the early detection of a tumor. Furthermore, it is crucial to avoid environmental factors leading to each type. This study provides relatively detailed and essential information regarding each subtype of renal carcinoma.

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“…The traditional hematoxylin and eosin (H&E) tissue staining method is the gold standard for PC diagnosis, but its complex and time-consuming procedure does not allow for intraoperative pathological diagnosis. 6 The immunofluorescence (IF) technique is advantageous in operability and timeliness compared to H&E staining, but the nonspecific adsorption of some commercial IF dyes in tumor and paracancerous tissues causes a lower signal-to-noise ratio, giving inaccurate imaging results. 7 In contrast, activatable fluorescent probes, whose fluorescence can be specifically triggered by biological species overexpressed in the tumor sites, display high sensitivity, realtime monitoring, and high tumor-to-normal signal-to-noise ratio.…”

Section: ■ Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

NQO-1 Enzyme-Activated NIR Theranostic Agent for Pancreatic Cancer

Peng

Chen

et al. 2022

Anal. Chem.

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Pancreatic cancer (PC) is one of the most lethal cancers worldwide, which is usually diagnosed in the advanced stage and is highly resistant to traditional chemotherapy, radiotherapy, and immunotherapy. Therefore, there is an urgent need for developing new PC-specific imaging and treatment. In this study, an quinone oxidoreductase 1 (NQO-1)-activated near-infrared (NIR) agent, ICy-Q, was synthesized. ICy-Q is almost nonemissive, while its NIR emission at 705 nm is triggered by NQO-1-induced reduction in the PC cells. In addition, the reduction product, ICy-OH, is specifically enriched in mitochondria and lysosomes and acts as an effective chemotherapeutic agent to selectively induce pancreatic cancer cell death via the cell pyroptosis pathway. Further studies have shown that ICy-Q is suitable for ex vivo imaging of clinical PC sections and solid tumors from patients. We expect this study will be helpful in the future for the design of targeted theranostic agents for PC.

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Urothelial carcinoma: variant histology, molecular subtyping, and immunophenotyping significant for treatment outcomes

Cited by 22 publications

References 100 publications

Identifying Potential Tumor Antigens and Antigens-Related Subtypes in Hepatocellular Carcinoma for mRNA Vaccine Development

Identifying Potential Tumor Antigens and Antigens-Related Subtypes in Hepatocellular Carcinoma for mRNA Vaccine Development

Etiologies, Gross Appearance, Histopathological Patterns, Prognosis, and Best Treatments for Subtypes of Renal Carcinoma: An Educational Review

NQO-1 Enzyme-Activated NIR Theranostic Agent for Pancreatic Cancer

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