Urothelial Carcinoma and its Variants

Magi‐Galluzzi, Cristina; Falzarano, Sara M.; Zhou, Ming

doi:10.1016/j.path.2008.07.004

Cited by 6 publications

(11 citation statements)

References 104 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For immunohistochemical (IHC) study, L1 antigen and cytokeratin (CK) 14 are positive in areas of squamous differentiation [4]. Areas of abundant squamous differentiation under the microscope are associated with a poor prognosis [5]. Radical cystectomy is the gold standard treatment, but chemotherapy and radiotherapy appear to be ineffective according to some studies [2] [6].…”

Section: ) the Squamous Differentiationmentioning

confidence: 99%

“…IHC is characterized by Apomucin MUC5AC and CK7 positive labeling and CDX2, CK20 and villin negative. The prognosis is worse when foci of glandular differentiation are numerous[5]. Radical cystectomy is the treatment of choice and resistancy to radio-chemotherapy is possible[5].…”

mentioning

confidence: 99%

“…Some cases have been described at a pT1 stage. Spindle cell carcinoma may be only a partial differentiation of urothelial carcinoma, but in general it constitutes the entire tumor mass[5]. The clinical presentation is aspecific, dominated by hematuria, dysuria, nocturia and acute retention of urine[14] [23].…”

mentioning

confidence: 99%

“…The clinical presentation is aspecific, dominated by hematuria, dysuria, nocturia and acute retention of urine[14] [23]. Macroscopically, these tumors form large polyploid buds protruding into the bladder lumen[5]. Histologically, the fusiform contingent is va-S. Regragui et al Open Journal of Pathology riable in appearance, abundance, uniform, epithelioid or heterologous differentiation of chondrosarcoma or osteosarcoma[5] (Figure 3).…”

mentioning

confidence: 99%

“…Macroscopically, these tumors form large polyploid buds protruding into the bladder lumen[5]. Histologically, the fusiform contingent is va-S. Regragui et al Open Journal of Pathology riable in appearance, abundance, uniform, epithelioid or heterologous differentiation of chondrosarcoma or osteosarcoma[5] (Figure 3). It merges with the urothelial contingent.…”

mentioning

confidence: 99%

See 4 more Smart Citations

The Histological Variants of Urothelial Carcinoma of the Bladder: It Is Affecting the Prognosis?

Regragui¹,

Touzani²,

Slaoui³

et al. 2020

OJPathology

View full text Add to dashboard Cite

Urothelial carcinomas (UC) are likely to have particular morphological features that distinguish them from the typical form. These original aspects are called "histological variants of urothelial carcinoma". They can constitute all or part of the tumor and concern mainly muscle invasive UC and high grade. Their frequency varies according to the type, but the knowledge of these variants is essential because of the diagnostic difficulties, and the implication of their presence on the prognosis.

show abstract

Section: ) the Squamous Differentiationmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

See 3 more Smart Citations

The Histological Variants of Urothelial Carcinoma of the Bladder: It Is Affecting the Prognosis?

Regragui¹,

Touzani²,

Slaoui³

et al. 2020

OJPathology

View full text Add to dashboard Cite

show abstract

Role of intraoperative touch imprint cytology and immunohistochemistry in the diagnosis of metastatic malignancies in the central nervous system: Cyto‐histomorphological findings and differential diagnosis

Koyuncuer

2023

Diagnostic Cytopathology

View full text Add to dashboard Cite

BackgroundBrain metastases (BMs) are intracranial neoplasms that are more common in adults than primary brain tumors, causing significant mortality and morbidity in cancer patients. This study aimed to evaluate the definitive histopathological diagnosis using touch imprint cytology and the importance and use of immunohistochemistry in the diagnosis of primary origin.MethodCytological, paraffin section, and immunohistochemical study slides of all metastatic brain tumors consecutively consulted at the pathology department between 2018 and 2023 were evaluated. The sensitivity, specificity, and accuracy of patients' diagnostic results who underwent imprint cytology were compared based on the final diagnosis histopathological report.ResultsA total of 45 patients with and without intraoperative consultation were included in the study. The definitive histopathologic diagnosis and the diagnostic accuracy rate of imprint cytology for distinguishing glial and metastatic tumors on paraffin sections was 100%. Immunohistochemistry was performed in all patients (except one patient; immediate exitus) and histological classification of the primary tumor was performed by analysis of clinical findings and biomarkers. The primary origins of metastatic tumors were often lung and breast, with adenocarcinoma subtype histomorphology, cerebral hemispheres, and discrete foci of metastasis.ConclusionTPs is a simple and rapid technique that supports diagnosis in intraoperative neuropathology and is a very cost‐effective procedure. The pathologist's experience is the key factor in the diagnosis and reduces the need for a frozen section. In our series, the final histopathologic correlation of imprint cytology in the diagnosis of primary and metastatic tumors is 100%.

show abstract

The comprehensive and systematic identification of BLCA-specific SF-regulated, survival-related AS events

Liu

Liu³

et al. 2022

Gene

View full text Add to dashboard Cite

Urothelial Carcinoma and its Variants

Cited by 6 publications

References 104 publications

The Histological Variants of Urothelial Carcinoma of the Bladder: It Is Affecting the Prognosis?

The Histological Variants of Urothelial Carcinoma of the Bladder: It Is Affecting the Prognosis?

Role of intraoperative touch imprint cytology and immunohistochemistry in the diagnosis of metastatic malignancies in the central nervous system: Cyto‐histomorphological findings and differential diagnosis

The comprehensive and systematic identification of BLCA-specific SF-regulated, survival-related AS events

Contact Info

Product

Resources

About