The comprehensive and systematic identification of BLCA-specific SF-regulated, survival-related AS events

Liu, Zhe; Li, Xudong; Liu, Fang; Zhao, Hui; Wang, Yafan; Ma, Ying; Zhang, Weitong; Petinrin, Olutomilayo Olayemi; Yao, Zujie; Liang, Jingbo; He, Qian; Feng, Dayun; Wang, Lei; Wong, Ka-Chun

doi:10.1016/j.gene.2022.146657

Cited by 6 publications

(4 citation statements)

References 36 publications

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“…Mining the independent factors is essential for prognostic analysis for cancer research (Liu et al 2022). Univariate Cox regression analysis was conducted to determine whether the clinical characteristics, such as age, gender, stage, tissue of origin, primary diagnosis, AJCC T, AJCC M, AJCC N, race, and risk score, were signi cantly associated with overall survival (OS) in STAD patients (P-value ≤ 0.05).…”

Section: Univariate and Multivariate Cox Regressionmentioning

confidence: 99%

“…Kaplan-Meier survival analyses and log-rank tests for each gene were carried out to assess the contributions of gene expression levels to global OS time (Liu et al 2022). Thirteen lncRNAs, 25 miRNAs, and nine mRNAs were put into this survival analysis model in order to identify the probable genes with substantial associations with the prognostic characteristics of patients with STAD.…”

Section: Survival Curves Of Cerna Network-related Genesmentioning

confidence: 99%

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Uncovering the ceRNA Network Related to the Prognosis of Stomach Adenocarcinoma among 898 Patient Samples

Wong¹

2023

Med Discoveries

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Section: Univariate and Multivariate Cox Regressionmentioning

confidence: 99%

Section: Survival Curves Of Cerna Network-related Genesmentioning

confidence: 99%

Uncovering the ceRNA Network Related to the Prognosis of Stomach Adenocarcinoma among 898 Patient Samples

Wong¹

2023

Med Discoveries

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“…In particular, Niu et al identified RNA splicing as one of the most dysregulated pathways in BCa using a proteomic approach (Niu et al, 2011). Additionally, Liu et al recently reported that more than 1500 alternative splicing events could be tightly associated with BCa prognosis (i.e., overall survival; Liu et al, 2022). Moreover, in stem-like CD8 + T-cells, a high expression of CXCR3alt, a splicing variant of the C-X-C chemokine receptor 3, has been recently identified as a predictor of chemotherapy response in BCa patients (Vollmer et al, 2021).…”

Section: Splicing Variantsmentioning

confidence: 99%

Alternative splicing in bladder cancer: potential strategies for cancer diagnosis, prognosis, and treatment

et al. 2022

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Bladder cancer is the most common malignancy of the urinary tract worldwide. The therapeutic options to tackle this disease comprise surgery, intravesical or systemic chemotherapy, and immunotherapy. Unfortunately, a wide number of patients ultimately become resistant to these treatments and develop aggressive metastatic disease, presenting a poor prognosis. Therefore, the identification of novel therapeutic approaches to tackle this devastating pathology is urgently needed. However, a significant limitation is that the progression and drug response of bladder cancer is strongly associated with its intrinsic molecular heterogeneity. In this sense, RNA splicing is recently gaining importance as a critical hallmark of cancer since can have a significant clinical value. In fact, a profound dysregulation of the splicing process has been reported in bladder cancer, especially in the expression of certain key splicing variants and circular RNAs with a potential clinical value as diagnostic/prognostic biomarkers or therapeutic targets in this pathology. Indeed, some authors have already evidenced a profound antitumor effect by targeting some splicing factors (e.g., PTBP1), mRNA splicing variants (e.g., PKM2, HYAL4-v1), and circular RNAs (e.g., circITCH, circMYLK), which illustrates new possibilities to significantly improve the management of this pathology. This review represents the first detailed overview of the splicing process and its alterations in bladder cancer, and highlights opportunities for the development of novel diagnostic/prognostic biomarkers and their clinical potential for the treatment of this devastating cancer type.

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“…Importantly, emerging studies have shown that mutations of target gene resulting in alternative splicing events can influence cancer susceptibility [ 16 ]. Similarly, various cancer-associated alternative splicing patterns have been found in multiple cancer tissues [ 17 18 ]. Alternative splicing is a fundamental process that affects the initiation and development of various cancers by affecting the biological functions of target gene [ 19 ].…”

Section: Introductionmentioning

confidence: 99%

Alternative splicing of PSMD13 mediated by genetic variants is significantly associated with endometrial cancer risk

Cao

Mao

et al. 2023

J Gynecol Oncol

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Objective Accumulating evidence has shown that aberrant alternative splicing events are closely associated with the onset and development of cancer. However, whether genetic variants-associated alternative splicing is linked to risk of endometrial cancer remains largely uncertain. Methods We identified single nucleotide polymorphisms (SNPs) locates in the splicing number trait locus (sQTL) of endometrial cancer using the CancerSplicing QTL database. In parallel with bioinformatics analysis, we conducted a case-control study comprising 2,000 cases and 2,013 controls to assess the association between identified SNP which possesses mRNA splicing function and endometrial cancer susceptibility. Furthermore, we used the Kaplan-Meier Plotter, The Human Protein Atlas, SPNR, and Spliceman2 databases for sQTL and differential gene expression analyses to identify the genetic variant which most potentially influence the risk of endometrial cancer through alternative splicing to reveal the potential mechanism by which candidate SNPs regulate the risk of endometrial cancer. Results The results indicated that SNP rs7128029 A

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The comprehensive and systematic identification of BLCA-specific SF-regulated, survival-related AS events

Cited by 6 publications

References 36 publications

Uncovering the ceRNA Network Related to the Prognosis of Stomach Adenocarcinoma among 898 Patient Samples

Uncovering the ceRNA Network Related to the Prognosis of Stomach Adenocarcinoma among 898 Patient Samples

Alternative splicing in bladder cancer: potential strategies for cancer diagnosis, prognosis, and treatment

Alternative splicing of PSMD13 mediated by genetic variants is significantly associated with endometrial cancer risk

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