1987
DOI: 10.1126/science.3498215
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Uromodulin (Tamm-Horsfall Glycoprotein): a Renal Ligand for Lymphokines

Abstract: The protein portion of the immunosuppressive glycoprotein uromodulin is identical to the Tamm-Horsfall urinary glycoprotein and is synthesized in the kidney. Evidence that the glycoproteins are the same is based on amino acid sequence identity, immunologic cross-reactivity, and tissue localization to the thick ascending limb of Henle's loop. Nucleic acid sequencing of clones for uromodulin isolated from a complementary DNA bank from human kidney predicts a protein 639 amino acids in length, including a 24--ami… Show more

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Cited by 265 publications
(188 citation statements)
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“…These latter findings also suggest a decreased function of this segment of the kidney after long term diabetes. The THP binds to and acts as a regulator of circulating interleukins such as recombinant murine interleukin-1 and recombinant tumour necrosis factor [38] and thus its decreased production in diabetes may influence immunologic reactions and growth. The number of nuclei in PT and DT tubules was not significantly lower 3 weeks after normalization of BG [28].…”
Section: Discussionmentioning
confidence: 99%
“…These latter findings also suggest a decreased function of this segment of the kidney after long term diabetes. The THP binds to and acts as a regulator of circulating interleukins such as recombinant murine interleukin-1 and recombinant tumour necrosis factor [38] and thus its decreased production in diabetes may influence immunologic reactions and growth. The number of nuclei in PT and DT tubules was not significantly lower 3 weeks after normalization of BG [28].…”
Section: Discussionmentioning
confidence: 99%
“…[25][26][27] Uromodulin, also named Tamm-Horsfall glycoprotein, was considered as the receptor of interleukin 1␣, interleukin 1␤ and tumor necrosis factor, and can suppress antigen-specific T-cell proliferation in vitro. 28,29 GP-2 is the major component of pancreatic secretory granule membranes and is suggested to play an important role in endocytosis along with src kinases and caveolin. [30][31][32] Tectorin ␣ and ␤ are presumed to play a key role during mouse inner ear development.…”
Section: Discussionmentioning
confidence: 99%
“…Individual nephron segments were identified by the use of antibodies to marker proteins specific to each segment based on previous studies: AQP1 for proximal tubules and thin descending limbs [2], CLC-K for thin ascending limbs [32,36], THP for the TAL [8], NCCT for distal convoluted tubules [14], and AQP2 for collecting ducts [6].…”
Section: Sodium Dodecyl Sulfate-polyacrylamide Gel Electrophoresis (Smentioning
confidence: 99%