Uroliths of cats in Switzerland from 2002 to 2009

Gerber, Bernhard; Brandenberger-Schenk, F; Rothenanger, E; Müller, Christoph

doi:10.17236/sat00089

Cited by 10 publications

(23 citation statements)

References 8 publications

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“…In this study, there was a significant risk for cats in the age groups of 1–6 years and 7–10 years, with an average age of 6.5 ± 3.6 years, similar to other studies. 1,3 Regarding the frequency of cases in different breeds, DSH cats were the most commonly affected; however, no significant differences were found when compared with the control group ( P = 0.47). Houston et al 4 found that Persian and Siamese cats are predisposed to forming CaOx uroliths vs domestic shorthair cats, and noted that domestic longhair cats were more likely to form struvite stones.…”

Section: Discussionmentioning

confidence: 80%

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Epidemiology of feline urolithiasis in Mexico (2006–2017)

Mendoza-López

Del-Angel-Caraza

Aké-Chiñas

et al. 2019

Journal of Feline Medicine and Surgery Open Reports

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ObjectivesThe objectives of this study were to identify the proportions of different types of uroliths, characterize the population of cats that present with urolithiasis and determine possible predisposing factors in a population of Mexican cats.MethodsThis study analyzed clinical specimens of feline urolithiasis submitted to our laboratory in the period from 2006 to 2017. The mineral composition of the uroliths was determined by qualitative and quantitative mineral analyses, performed by stereoscopic microscopy and infrared spectroscopy.ResultsIn the population studied, 54.3% of all uroliths were calcium oxalate, followed by 32.1% struvite and 7.4% purine (urate and xanthine) uroliths, with other types accounting for 6.2% of submissions. The male:female ratio was 1.2:1. Calcium oxalate submissions were predominantly from males and struvite submissions were predominantly from females. The age of the cats with stone submissions ranged from 6 months to 17 years. In cats with calcium oxalate uroliths, 52.3% were aged 7 years or older. Cats with struvite uroliths were younger, with 65.4% younger than 6 years of age. Almost 90% of all submitted uroliths were from domestic shorthair cats.Conclusions and relevanceThis is the first epidemiologic study of urolithiasis in cats in Mexico. Age and sex predispositions to common uroliths were identified, as males aged ≥7 years primarily presented with calcium oxalate uroliths and females aged <6 years primarily presented struvite uroliths. Cases of urolithiasis of genetic origin, including xanthinuria and cystinuria, were also detected, in addition to silicate uroliths.

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Section: Discussionmentioning

confidence: 80%

“…Other studies have observed a higher frequency of urolithiasis in males. 1,3,4 Predisposed cats can form uroliths at any age. In this study, there was a significant risk for cats in the age groups of 1–6 years and 7–10 years, with an average age of 6.5 ± 3.6 years, similar to other studies.…”

Section: Discussionmentioning

confidence: 99%

Epidemiology of feline urolithiasis in Mexico (2006–2017)

Mendoza-López

Del-Angel-Caraza

Aké-Chiñas

et al. 2019

Journal of Feline Medicine and Surgery Open Reports

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“…This fact can be confirmed by increasing number of owners of pets with urolithiasis, looking for help in veterinary clinics (3,4). Urolithiasis is widespread disease, could be found in many species, including cats, dogs, rabbits, guinea-pigs, turtles etc (1,(4)(5)(6). Despite the large scale of this pathology in animal world, there are some challenges with diagnostic process and diagnosis's verification (1,7).…”

Section: Introductionmentioning

confidence: 95%

Possibilities of urolithiasis crystallodiagnostics

Мартусевич¹,

Kozlova²

2017

IJVS

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Nowadays, one of the most common groups of diseases in veterinary medicine is the urinary system pathology. Urolithiasis is widespread disease, could be found in many species, including cats, dogs, rabbits, guinea-pigs, turtles etc. Despite the large scale of this pathology in animal world, there are some challenges with diagnostic process and diagnosis's verification. The aim of our study is estimation of diagnostic value of advanced urine tesiocrystalloscopy in urolithiasis (by the example of cats). We studied crystallogenic and initiated properties of 24 healthy cats and 32 animals with urolithiasis. Own and initiated crystallogenesis of the urine specimens was studied. For teziographic test we used sodium chloride solution (0.45%, 0.9%, 3% consequently), hydrochloric acid solution (0.1H) and sodium hydroxide (0.1H) as a crystal-forming substances. We used the original criterions to estimate crystalloscopic and tezigraphic facias. As the main parameters structure index (SI), crystallizability (Cr), facia's destruction degree (FDD) and edge belt intensity (EB) were used to describe free crystallogenesis, and main tezigraphic coefficient (Q), belt coefficient (B) and FDD were used for the comparative tezigraphy data. Results showed that Cat's urine in normal conditions has moderate crystallogenic activity, but in urolithiasis it acquires high level of crystallizing, with intermedium value of structure index, and significant destruction of crystal-forming elements. A similar changes of physical-chemical biomedium properties are detected during analysis of tezigraphic microslides of urines of cats with urolithiasis, that was prepared using 0.9% sodium chloride as basis substance. In conclusion, we fixed that tesiocristalloscopic "pattern" of cats' urine in urolithiasis significantly transforms into activation of crystal formation and increasing of biomedium's initiating potential. So, the investigation of free or initialized urine crystallization in urolithiasis has diagnostic value.

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“…In 1991, a cystinuric domestic cat was first described (4) and in 1999 eighteen cases were briefly summarized (34). According to urolith laboratories, cystine calculi represent only up to 0.5% in Germany (and neighboring countries) (7, 13) and 0.1% of all feline uroliths in North America (31) compared with 4.4% of all canine calculi in Europe (12) and 0.3–1% in North America (31). Cystinuria was reported equally in male and female cats and independently of neuter status and thus an androgen-dependent cystinuria type seems unlikely (34).…”

Section: Introductionmentioning

confidence: 99%

Cystinurie aufgrund einer SLC7A9-Missense-Mutation bei Siammischlingskatzen eines Wurfs in Deutschland

Hilton¹,

Mizukami²,

Giger³

2017

Tierarztl Prax Ausg K

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Summary Cystinuria is caused by defective proximal renal tubular reabsorption of the amino acids cystine, ornithine, lysine and arginine (COLA). The low solubility of cystine in mildly acidic urine may lead to the formation of urinary cystine crystals and uroliths. Much progress has been made recently in the diagnosis and understanding of cystinuria in companion animals. In cats, cystinuria affects equally both genders independent of neutering status and, despite being rare, already more cystinuria-causing mutations have been detected in cats compared to dogs. In this study a litter of Siamese-crossbred cats in Germany was assessed clinically for cystinuria and screened for mutations known to cause cystinuria in cats. An adult male castrated cat was presented with cystine crystalluria and calculi-related urinary obstruction and treated with perineal urethrostomy, cystotomy and medical management. This cat and a neutered male littermate without evidence of urinary tract disease were found to be positive for cystine by urinary nitroprusside test, to have increased urinary COLA values and to be homozygous for the p.Val294Glu mutation in the SLC7A9 gene coding for b0,+AT subunit of the b0,+ renal COLA transporter. Another littermate was non-cystinuric and did not carry this mutation. The same SLC7A9 mutation was previously found in a Maine coon, a Sphinx and a medium-haired cat in North America suggesting a common ancestor and likely first widespread SLC7A9 mutation causing cystinuria in cats. Genetic screening for this mutation may offer a simple and precise mean to diagnose other cats for cystinuria and offer specific management.

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Uroliths of cats in Switzerland from 2002 to 2009

Cited by 10 publications

References 8 publications

Epidemiology of feline urolithiasis in Mexico (2006–2017)

Epidemiology of feline urolithiasis in Mexico (2006–2017)

Possibilities of urolithiasis crystallodiagnostics

Cystinurie aufgrund einer SLC7A9-Missense-Mutation bei Siammischlingskatzen eines Wurfs in Deutschland

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