Urographic Contrast Media and Methods of Investigative Uroradiology

Golman, Klaes; Almén, Torsten

doi:10.1007/978-3-642-69515-5_3

Cited by 17 publications

(9 citation statements)

References 167 publications

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“…The osmolality de fines the urinary CM concentration, which, however, can not explain the difference: the vacuolization was most marked at the beginning of the PCT. where the CM con centrations should be identical [31], because the contrast agents are freely filtrated in the glomeruli [32], Even in a more distant part of the renal tubule the concentrations should remain almost parallel, because the osmotic diure sis, induced by these low osmolal CMs, should be of about the same degree. Furthermore, in our previous study high osmolal diatrizoate generated less vacuolization than isoosmolal iotrolan [33]: the lysosomal alteration does not explicitly depend on the osmolality of the CM injected [16,30].…”

Section: Discussionmentioning

confidence: 99%

Structural Changes in the Renal Proximal Tubular Cells Induced by lodinated Contrast Media

Tervahartiala

Kivisaari

et al. 1997

Nephron

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The renal morphologic changes induced by intravenously injected contrast media (CMs) were studied in 40 Wistar rats which had been deprived of water 24 h before the CM injection. In the first part of the investigation, the kidneys were fixed by perfusion for light and electron microscopy 2 h after injection of 3 g iodine/kg of iopamidol, iobitridol or iohexol. Control animals received physiologic saline. In the second part of the study, the fixation was performed 48 h after the injection of the corresponding dose of iobitridol or iohexol. The structural changes were semiquantitatively evaluated by two independent observers unaware of the agent injected. The lysosomes of the proximal convoluted tubular cells showed moderate changes 2 h after the iopamidol injection. Iobitridol and iohexol induced prominent lysosomal alterations with signs of cytoplasmic injury. After 48 h, the changes induced by iobitridol had almost disappeared, whereas the iohexol group still showed a statistically significant vacuolization. Although the general physicochemical properties of iobitridol and iohexol appear similar in vitro, the different lysosomal alteration might reflect differences in their characteristics in vivo.

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Section: Discussionmentioning

confidence: 99%

Structural Changes in the Renal Proximal Tubular Cells Induced by lodinated Contrast Media

Tervahartiala

Kivisaari

et al. 1997

Nephron

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“…In rabbits, chosen for the present study, both high and low sensitivity to CM have been reported (3,8). The present study revealed no signs of renal injury except for a temporary significant increase in the excretion of the brush border enzyme GGT in rabbits receiving diatrizoate.…”

Section: Discussionmentioning

confidence: 66%

Effects of Intravenous Injection of Diatrizoate, Iohexol or Ioxilan on Renal Size, Urine Profiles and Blood Profiles in the Rabbit

Rygaard¹,

Dorph²,

Thomsen³

et al. 1988

Acta Radiol

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Diatrizoate, iohexol or ioxilan were injected intravenously in 18 rabbits. The contrast medium passage through the kidneys was recorded on digital subtraction images for the first 50 s followed by 100 mm exposures up to 15 min after injection. The renal area was measured planimetrically. Urine profiles (glucose, phosphate, LDH, GGT, NAG), blood profiles (potassium, urea) and the relative clearance of albumin and sodium were followed for 5 days and compared with a control group injected with saline. All kidneys were examined by light and immunofluorescence microscopy. All three contrast media produced excellent arteriograms and urograms. The three different contrast media caused a rapid increase of the kidney area within the first minute, reaching an average maximum of 10 to 12 per cent after 5 min, followed by a gradual decline. Contrary to expectations the increase in renal area was similar for all three contrast media, so hyperosmolality is no likely explanation of this phenomenon. None of the contrast agents caused significant changes in any of the profile components with one exception: the GGT excretion was significantly elevated during the first 24 h after diatrizoate administration as compared with the effect of saline. Light and immunofluorescence microscopy revealed no differences.

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“…In other cases oliguria, or even anuria, may appear soon after angiography, necessitating temporary dialysis. In some patients chronic renal failure has been reported (6,7).…”

Section: Discussionmentioning

confidence: 99%

“…Iodinated contrast media are excreted by glomerular filtration (5,6) and therefore can be used as filtration markers. The total plasma clearance after a single injection of contrast medium can readily be determined with the aid of x-ray fluorescence analysis (1, 2, 8-1 I ) and calculated by the same procedure as for single injection "Cr-EDTA clearance (2,3,10,11).…”

mentioning

confidence: 99%

Glomerular filtration rate estimated after multiple injections of contrast medium during angiography

et al. 1988

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Urographic Contrast Media and Methods of Investigative Uroradiology

Cited by 17 publications

References 167 publications

Structural Changes in the Renal Proximal Tubular Cells Induced by lodinated Contrast Media

Structural Changes in the Renal Proximal Tubular Cells Induced by lodinated Contrast Media

Effects of Intravenous Injection of Diatrizoate, Iohexol or Ioxilan on Renal Size, Urine Profiles and Blood Profiles in the Rabbit

Glomerular filtration rate estimated after multiple injections of contrast medium during angiography

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