Glomerular filtration rate estimated after multiple injections of contrast medium during angiography

Boijsen, Marianne; Granérus, G.; Jacobsson, Lars; Björneld, L.; Aurell, Mattias; Tylén, Ulf

doi:10.1080/02841858809171962

Cited by 13 publications

(3 citation statements)

References 12 publications

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“…In this study, we were able to directly assess GFR through plasma disappearance of iohexol administered at the time of routine cardiac catheterization, eliminating the need for additional contrast administration or time in the hospital. Assessment of GFR by clearance of contrast media has been previously described in adults undergoing angiography . In the Artunc study of 127 adults undergoing contrast administration of 10–350 mL of contrast agent over a time span of up to 60 min during elective cardiac catheterization, serum cystatin C measurements correlated better with iopromide clearance (r = 0.805) than did serum creatinine‐based estimates of GFR (r = 0.690).…”

Section: Discussionmentioning

confidence: 99%

Renal function assessment in child and adolescent heart transplant recipients during routine cardiac catheterization

Lin

Furth

Schwartz

et al. 2014

Pediatric Transplantation

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CKD identification after pediatric heart transplantation (PHT) is limited by inaccuracies in estimates of GFR. We hypothesized that GFR can be measured by a modified iohexol clearance protocol in PHT recipients and that the CKiD formula provides a better estimate of GFR than other estimating equations. A cross-sectional study of PHT recipients, ages 2-18 yr, undergoing coronary angiography was undertaken. The angiography dose of iohexol was divided by the area under the curve from three iohexol levels post-infusion to calculate GFR. Agreement between iGFR and multiple estimating equations (eGFR) was assessed. In 31 subjects, median age was 15.0 yr (IQR 7.6, 16.6). Mean iGFR was 93.8 (s.d. 22.5) mL/min/1.73 m(2) ; 16 (52%) had an iGFR <90 mL/min/1.73 m(2) . The full CKiD formula (mean eGFR 88.9, s.d. 14.9) had low bias (-5.0), narrowest 95% limits of agreement (-42.0, 32.1), highest 30% (94%) and 10% (52%) accuracy, and highest correlation coefficient (0.576) relative to iGFR. We describe a novel modified iohexol clearance method to assess GFR after PHT. Over half of the cohort had an iGFR <90, suggesting CKD. The full CKiD formula performs best with respect to bias, accuracy, and correlation.

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Section: Discussionmentioning

confidence: 99%

Renal function assessment in child and adolescent heart transplant recipients during routine cardiac catheterization

Lin

Furth

Schwartz

et al. 2014

Pediatric Transplantation

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“…3. It is more comfortable for the patient to receive only one dose of contrast medium for the dual purpose of diagnostic imaging such as urography, angiography or CT and measurement of GFR in the same clinical setting [11,38,39,40,41,42,43,44,45].…”

Section: Choice Of Gfr Markermentioning

confidence: 99%

Contrast media as markers of GFR

Frennby

Sterner

2001

Eur Radiol

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Determination of the glomerular filtration rate (GFR) is generally considered as the most important parameter of quantifying renal function. The GFR is determined as renal or plasma clearance of an ideal filtration marker which is freely filtered by the kidney, does not undergo metabolism, tubular secretion or absorption. Markers that fulfil these demands are inulin, 51Cr-EDTA, 99mTc-DTPA, labelled or unlabelled contrast media. The renal clearance of inulin is the classic reference method for estimation of the GFR. This method is however not practical for routine clinical purposes. Radionucleids have therefore been used as alternative filtration markers since the 60s. Drawbacks related to radiation exposure especially in children and pregnant women and the safety in handling radiolabelled markers have led to an increasing interest in using non-radioactive markers. The development of simple and reliable methods to determine the concentration of contrast media in plasma and urine, such as high-performance liquid chromatography (HPLC) and X-ray fluorescence analysis have made this possible. The non-ionic low osmolar contrast medium iohexol has become the most commonly used contrast medium for GFR measurements in Europe. However, other contrast media with similar pharmacokinetics may be equally suitable as GFR markers.

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“…An ideal GFR marker is often considered as an agent that does not bind to plasma proteins, has no significant systemic metabolism and is freely excreted through glomerular filtration [4,5]. Traditionally, clearance of inulin, a simple sugar administered intravenously, is considered the gold standard for GFR measurement.…”

Section: Introductionmentioning

confidence: 99%

Development and validation of an HPLC-UV method for iodixanol quantification in human plasma

Chitnis

Akhlaghi

2008

Journal of Chromatography B

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Glomerular filtration rate estimated after multiple injections of contrast medium during angiography

Cited by 13 publications

References 12 publications

Renal function assessment in child and adolescent heart transplant recipients during routine cardiac catheterization

Renal function assessment in child and adolescent heart transplant recipients during routine cardiac catheterization

Contrast media as markers of GFR

Development and validation of an HPLC-UV method for iodixanol quantification in human plasma

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