Urine α-Glutathione S-Transferase, systemic inflammation and arterial function in juvenile type 1 diabetes

Holmquist, Peter; Liuba, Petru

doi:10.1016/j.jdiacomp.2012.03.023

Cited by 7 publications

(6 citation statements)

References 26 publications

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“…The authors were not able to reconcile these discordant findings, and suggested that further studies should evaluate the diagnostic relevance of this ratio in T1DM. 18 …”

Section: Potential New Biomarkers Of Diabetic Nephropathymentioning

confidence: 99%

The possible role of glutathione-S-transferase activity in diabetic nephropathy

Tesauro

Nisticò

Noce

et al. 2015

Int J Immunopathol Pharmacol

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The most common cause of end stage renal disease is diabetic nephropathy. An early diagnosis may allow an intervention to slow down disease progression. Recently, it has been hypothesized that glutathione-S-transferase (GST) activity may be a marker of severity of chronic kidney disease. In particular, a lower GST activity is present in healthy subjects compared to patients with nephropathy. In the present review we illustrate the scientific evidence underlying the possible role of GST activity in the development of diabetic nephropathy and we analyze its usefulness as a possible early biomarker of this diabetic complication.

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“…The authors were not able to reconcile these discordant findings, and suggested that further studies should evaluate the diagnostic relevance of this ratio in T1DM. 18 …”

Section: Potential New Biomarkers Of Diabetic Nephropathymentioning

confidence: 99%

The possible role of glutathione-S-transferase activity in diabetic nephropathy

Tesauro

Nisticò

Noce

et al. 2015

Int J Immunopathol Pharmacol

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“…Of the 184 children with type1 diabetes (duration > 6 months) enrolled in a previous study on urine excretion of GST enzymes [16], 71 were included in another study carried out within the same timeframe investigating vascular (carotid artery intima media thickness (IMT), and skin microvascular endothelial function) and inflammatory (C-reactive protein (CRP)) parameters. Exposure to environmental tobacco smoke (ETS) was assessed via questionnaire [1], and defined as occasional or regular cigarette smoking in the presence of study participants in or outside home (e.g.…”

Section: Subjectsmentioning

confidence: 99%

Welche Rolle spielt die Therapieadhärenz?

Jung¹,

Geiger²

2014

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BackgroundRenal disease remains a serious threat in patients with insulin-dependent (type1) diabetes. Hence its detection early in the life of patients with type1 diabetes is crucial. Several lines of evidence suggest similar mechanisms for the development of both renal and arterial disease. We sought to investigate in young patients with type1 diabetes whether π-Glutathione S-transferase to creatinine (π-GST:crea) and Tamm-Horsfall protein to creatinine (THP:crea) ratios, markers of distal tubular renal function, relate to subclinical markers of arterial disease, which appear to onset early and develop rapidly in type1 diabetes.MethodsSeventy-one children and adolescents (median age and diabetes duration 14 and 6 years, respectively) with type1 diabetes for at least 6 months were assessed for timed urine levels of π-GST, THP, HbA1c, albumin, and plasma C-reactive protein (CRP). Carotid artery intima-media thickness (IMT), brachial artery flow-mediated dilatation (FMD), and cutaneous microvascular function were assessed by high-resolution ultrasound and laser Doppler, respectively.ResultsTwo patients had microalbuminuria (> 20 μg/min), and were therefore removed from the study population. π-GST:crea ratio and THP:crea showed no relationship to the demographic, diabetes, or inflammatory indices. Lower π-GST:crea ratio was associated with greater IMT (p = 0.01, r = −0.29), particularly in female patients (p = 0.004, r = −0.49). The association of π-GST:crea ratio with IMT was stronger in patients with passive smoke exposure (p = 0.002, r = −0.43). Among post-pubertal patients, lower π-GST:crea ratio was also associated with lower microvascular response to Ach (acetylcholine; p = 0.03, r = 0.49).ConclusionsIn young patients with type1 diabetes, proximal tubular dysfunction as suggested by lower levels of π-GST:crea ratio seems to be paralleled by changes in arterial structure and microvascular function.

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“…4 Therefore, GST is a suitable indicator for processes damaging the tubular epithelium of the kidney. 4,5 GST is also employed to tag recombinant proteins, which can be further purified by glutathione (GSH)-bound affinity chromatography making use of GSH−GST specific interaction. 6−8 A sandwich enzyme-linked immunosorbend assay (ELISA) method was presented for quantitative monitoring of recombinant fusion proteins containing GST.…”

Section: ■ Introductionmentioning

confidence: 99%

Turn-on Fluorescent Sensing of Glutathione S-Transferase at near-Infrared Region Based on FRET between Gold Nanoclusters and Gold Nanorods

Qin

Chen

et al. 2015

ACS Appl. Mater. Interfaces

104

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A fluorescence resonance energy transfer (FRET) method based on gold nanoclusters capped glutathione (AuNCs@GSH) and amine-terminated gold nanorods (AuNRs) is designed for turn-on and near-infrared region (NIR) sensing of glutathione S-transferase (GST). The absorption band of AuNRs is tuned carefully to maximize the spectra overlap and enhance the efficiency of FRET. The FRET from multiple AuNCs to single AuNR quenches about 70% fluorescence emission of AuNCs. After GST is added, the strong specific interaction of GSH-GST can replace the AuNCs@GSH from AuNRs, FRET based on electrostatic interaction between AuNCs@GSH and AuNRs is switched off. Thus, emission enhancement of AuNCs@GSH is observed. The fluorescent enhancement is linearly with the increasing GST concentration over the range of 2-100 nM GST and the limit of detection for GST is about 1.5 nM.

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Urine α-Glutathione S-Transferase, systemic inflammation and arterial function in juvenile type 1 diabetes

Abstract: Background: Despite marked improvement in therapy and monitoring of patients with insulin-

Cited by 7 publications

References 26 publications

The possible role of glutathione-S-transferase activity in diabetic nephropathy

The possible role of glutathione-S-transferase activity in diabetic nephropathy

Welche Rolle spielt die Therapieadhärenz?

Turn-on Fluorescent Sensing of Glutathione S-Transferase at near-Infrared Region Based on FRET between Gold Nanoclusters and Gold Nanorods

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