Urine-derived induced pluripotent stem cells as a modeling tool to study rare human diseases

Shi, Liang; Cui, Yazhou; Luan, Jing; Zhou, Xiaoyan; Han, Jinxiang

doi:10.5582/irdr.2016.01062

Cited by 27 publications

(12 citation statements)

References 94 publications

(72 reference statements)

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“…One such example is hemophilia A, from which iPSC were previously generated from human UDSC, which were further differentiated into hepatocytes that did not produce blood coagulation factor VIII, resembling patient cells [88]. Since the isolation of UDSC is noninvasive, they are a safe and promising source of stem cells from patients with bleeding disorders, since all invasive procedures are life-threatening for them [89]. The CRISPR-Cas9 nuclease system was successfully used by Park et al on iPSC from patients with hemophilia A caused by chromosomal inversions that involve introns 1 and 22 of the F8 (blood coagulation factor VIII) gene [90].…”

Section: Potential or Current Utilization Of Urine-derived Stem Cellsmentioning

confidence: 99%

Urine-Derived Stem Cells: Applications in Regenerative and Predictive Medicine

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Шафигуллина

Rizvanov

et al. 2020

Cells

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Despite being a biological waste, human urine contains a small population of cells with self-renewal capacity and differentiation potential into several cell types. Being derived from the convoluted tubules of nephron, renal pelvis, ureters, bladder and urethra, urine-derived stem cells (UDSC) have a similar phenotype to mesenchymal stroma cells (MSC) and can be reprogrammed into iPSC (induced pluripotent stem cells). Having simple, safer, low-cost and noninvasive collection procedures, the interest in UDSC has been growing in the last decade. With great potential in regenerative medicine applications, UDSC can also be used as biological models for pharmacology and toxicology tests. This review describes UDSC biological characteristics and differentiation potential and their possible use, including the potential of UDSC-derived iPSC to be used in drug discovery and toxicology, as well as in regenerative medicine. Being a new cellular platform amenable to noninvasive collection for disease stratification and personalized therapy could be a future application for UDSC.

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Section: Potential or Current Utilization Of Urine-derived Stem Cellsmentioning

confidence: 99%

Urine-Derived Stem Cells: Applications in Regenerative and Predictive Medicine

Bento

Шафигуллина

Rizvanov

et al. 2020

Cells

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“…In addition, the ability to expand to a large amount and to be induced into various cell lineages is also the basis for the somatic stem cells to explore their application in cell-based therapies and regenerative medicine. UDSCs could be expanded to yield a large population, and their plasticity has also been fully confirmed through investigation [ 17 ].…”

Section: Multiple Transdifferentiation Of Udscs Applied In Cell Thmentioning

confidence: 99%

Urine-Derived Stem Cells: The Present and the Future

Wang

Chen

et al. 2017

Stem Cells International

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Stem cell research provides promising strategies in improving healthcare for human beings. As a noninvasively obtained and easy-to-culture cell resource with relatively low expense, urine-derived stem cells have special advantages. They have been extensively studied on its proliferation ability and differentiation potential and were being reprogrammed to model diseases during the last decade. In this review, we intend to summarize the latest progress on the research of urine-derived stem cells for its broad application mainly in regenerative medicine and disease modeling, as well as in what is challenging currently. This minireview will highlight the potential application of urine-derived stem cells and provides possible direction of further research in the future.

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“…The automation of the urine cell cultures will make it easy to achieve the numbers for human transplantation. As a universal sample of collection, urine-derived cells can serve as an outstanding option for treatment of diseases such as those in the kidney, brain and paediatrics [ 84 ]. With more extensive study, urine cells can be employed as a preservation method for patient cells to serve as a cell bank for therapy and disease modelling study by generating iPSC (Fig.…”

Section: Discussionmentioning

confidence: 99%

Urine-derived cells for human cell therapy

et al. 2018

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Desirable cells for human cell therapy would be ones that can be generated by simple isolation and culture techniques using a donor sample obtained by non-invasive methods. To date, the different donor-specific cells that can be isolated from blood, skin, and hair require invasive methods for sample isolation and incorporate complex and costly reagents to culture. These cells also take considerable time for their in-vitro isolation and expansion. Previous studies suggest that donor-derived cells, namely urine stem cells and renal cells, may be isolated from human urine samples using a cost-effective and simple method of isolation, incorporating not such complex reagents. Moreover, the isolated cells, particularly urine stem cells, are superior to conventional stem cell sources in terms of favourable gene profile and inherent multipotent potential. Transdifferentiation or differentiation of human urine-derived cells can generate desirable cells for regenerative therapy. In this review, we intended to discuss the characteristics and therapeutic applications of urine-derived cells for human cell therapy. Conclusively, with detailed study and optimisation, urine-derived cells have a prospective future to generate functional lineage-specific cells for patients from a clinical translation point of view.

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Urine-derived induced pluripotent stem cells as a modeling tool to study rare human diseases

Cited by 27 publications

References 94 publications

Urine-Derived Stem Cells: Applications in Regenerative and Predictive Medicine

Urine-Derived Stem Cells: Applications in Regenerative and Predictive Medicine

Urine-Derived Stem Cells: The Present and the Future

Urine-derived cells for human cell therapy

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