Urine albumin and serum uric acid are important determinants of serum 25 hydroxyvitamin D level in pre-dialysis chronic kidney disease patients

Nokeety, Mahmoud M El; Heikal, Ahmed A.; Sadek, Khaled; Hammad, Hany; Abdulazim, Dina O.; Salem, Mona M; Din, Usama A Sharaf El

doi:10.1080/0886022x.2018.1563552

Cited by 3 publications

(4 citation statements)

References 41 publications

(41 reference statements)

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“…However, we did not find a causal effect of serum urate on the markers of systematic inflammation. Previous studies have observed the associations between serum urate and serum inflammation indicators ( 13 , 61 , 62 ). Our study indicates that these associations are not causal.…”

Section: Discussionmentioning

confidence: 95%

Associations between serum urate and telomere length and inflammation markers: Evidence from UK Biobank cohort

Cui²,

Zhang³

2022

Front. Immunol.

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ObjectiveHyperuricemia and gout have become gradually more common. The effect of serum urate on organism aging and systematic inflammation is not determined. This study aims to evaluate whether serum urate is causally associated with cellular aging markers and serum inflammation markers.MethodsA Mendelian randomization study was performed on summary-level data from the largest published genome-wide association studies. Single nucleotide polymorphisms with a genome-wide significance level were selected as instrumental variables for leukocyte telomere length (LTL), and serum soluble makers of inflammation (CRP, IL-6, TNF-α, and IGF-1). Standard inverse variance weighted (IVW) method was used as the primary statistical method. The weighted median, MR-Egger regression, and MR-PRESSO methods were used for sensitivity analysis.ResultsAn inverse causal association of genetically predicted serum urate levels and LTL was found using IVW method (OR: 0.96, 95%CI 0.95, 0.97; β=-0.040; SE=0.0072; P=4.37×10-8). The association was also supported by MR results using MR-Egger method and weighted median method. The MR-PRESSO analysis and leave-one-out sensitivity analysis supported the robustness of the combined results. In terms of other aging-related serum biomarkers, there was no evidence supporting a causal effect of serum urate on CRP, IL-6, TNF-α, or IGF-1 levels.ConclusionsSerum urate levels are negatively associated with telomere length but are not associated with serum soluble indicators of inflammation. Telomere length may be a critical marker that reflects urate-related organismal aging and may be a mechanism in the age-related pathologies and mortality caused by hyperuricemia.

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Section: Discussionmentioning

confidence: 95%

Associations between serum urate and telomere length and inflammation markers: Evidence from UK Biobank cohort

Cui²,

Zhang³

2022

Front. Immunol.

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“…41, 42 Recent study also reported that uric acid was an important predictor of low serum 25(OH)VitD 3 form of vitamin D in predialysis CKD patients. 43 None of the study reported a correlation between serum uric acid and 1,25(OH) 2 VitD 3 to our knowledge until now. 1,25(OH) 2 VitD 3 or calcitriol is the physiologically active form of vitD, but 25(OH)VitD 3 is the main form in the blood stream and the best indicator of vitD status because 1,25(OH) 2 VitD 3 levels are influenced by PTH abnormalities.…”

Section: Discussionmentioning

confidence: 71%

Serum Uric Acid and Coronary Arterial Disease in Predialysis Chronic Kidney Disease Patients

Raikou

Vlaseros

Kyriaki

et al. 2021

Indian Journal of Clinical Cardiology

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Background–Aim: Uric acid is considered a marker of high cardiovascular risk. We investigated the association between serum uric acid and coronary arterial disease (CAD) in pre-dialysis chronic kidney disease (CKD) patients. Methods: We enrolled 110 subjects on mean age 69.02 ± 14.3 years old. The participants were categorized for both estimated glomerular filtration rate (eGFR) and albuminuria according to criteria 2012 of the Kidney Disease Improving Global Outcomes. Estimated pulse wave velocity (ePWV) was calculated using an equation including the age and mean blood pressure. The CAD prevalence rate was recorded. Results: The patients were divided in two groups according to uric acid cutoff point value related to high ePWV. The patients with higher uric acid were older and they had significantly higher systolic blood pressure, pulse pressure, and parathyroid hormone, but significantly lower eGFR and 1,25(OH)2 Vit D3 levels. The association between high uric acid and both high ePWV and CAD occurrence was found to be significant ( x2 = 6.7, P = .008 and x2 = 4.1, P = .03, respectively), although the relationship with albuminuria was found to be nonsignificant. In a built multifactorial model, the low serum uric acid rather than the high was found to be an independent predictor for CAD demonstration entering traditional and specific confounders. Conclusion: The low serum uric acid levels were proved to be a significant predictor for CAD accounting potential covariates, even though the high uric acid per se was found to be connected with cardiovascular disease characteristics including arterial stiffness in predialysis CKD patients.

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“…Apart from the study done by Vanholder et al [12], there is no studies that looked for the impact of hypouricemic therapy on serum 25 (OH) vit D in spite of the reported association between vitamin D insufficiency and hyperuricemia in CKD patients [10] and healthy personnel [14]. In that study, 300 mg of allopurinol given daily to 9 CKD patients significantly increased 1,25 (OH) 2 vit D but failed to change serum 25 (OH) vit D [12].…”

Section: Discussionmentioning

confidence: 99%

“…Elevated serum uric acid (SUA) and serum phosphorus are frequently encountered in CKD patients [7-9]. Previous studies have reported negative associations of serum 25 (OH) vit D with either SUA or serum phosphorus [9, 10]. So far, there is no clear explanation for these negative associations.…”

Section: Introductionmentioning

confidence: 99%

Serum Urate Lowering Therapy Using Allopurinol Improves Serum 25 Hydroxy Vitamin D in Stage 3-5 CKD Patients: A Pilot Study

Mohammed

Marie

Abdulazim

et al. 2020

Nephron

Self Cite

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Background: Recent studies have demonstrated negative associations of serum uric acid (SUA) with serum 25 hydroxy vitamin D (25 [OH] vit D) among CKD patients. Objective: The aim of the study was to look for the impact of hypouricemic therapy using allopurinol on serum level of 25 (OH) vit D in CKD patients. Cases and Methods: Seventy-two CKD stage 3–5 patients were selected to this study. Patients with SUA above 7 mg/dL were allocated to hypouricemic therapy using allopurinol (group I). A control group of cases not suffering marked increase in SUA were included as control group (group II). All cases were followed up for 3 months. Serum Cr, SUA, ionized calcium (SiCa), phosphorus, 25 (OH) vitD, parathyroid hormone (PTH), and 24-h urine protein were estimated at entry and by the end of the study. Results: At least 20 cases completed the study in each group. Serum 25 (OH) vit D significantly increased in group I (26.4 [14.1] vs. 39.6 [14.8] at entry vs. at end of the study, p < 0.001). In addition, SUA, PTH, and urine protein significantly decreased (11 [1.6] vs. 3.95 [0.58] mg/dL, 267.5 [97.5] vs. 225.5 [153] ng/mL, and 2.7 [1.18] vs. 1.5 [1.08] gm/day, p < 0.001, = 0.043, and <0.001 respectively). SiCa and phosphorus significantly increased (4.4 [0.3] vs. 5.2 [0.5] mg/dL and 4.25 [0.72] vs. 4.9 [0.75] mg/dL, p < 0.001 and = 0.007, respectively). Conclusion: This study supports a negative causal relationship between SUA and serum 25 (OH) vit D. Further studies are still needed to confirm this conclusion.

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Urine albumin and serum uric acid are important determinants of serum 25 hydroxyvitamin D level in pre-dialysis chronic kidney disease patients

Cited by 3 publications

References 41 publications

Associations between serum urate and telomere length and inflammation markers: Evidence from UK Biobank cohort

Associations between serum urate and telomere length and inflammation markers: Evidence from UK Biobank cohort

Serum Uric Acid and Coronary Arterial Disease in Predialysis Chronic Kidney Disease Patients

Serum Urate Lowering Therapy Using Allopurinol Improves Serum 25 Hydroxy Vitamin D in Stage 3-5 CKD Patients: A Pilot Study

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