Urinary uric acid and antioxidant capacity in children and adults with Down syndrome

Campos, Carlos; Guzmán, Rodrigo; López-Fernández, Encarnación; Casado, Ángela

doi:10.1016/j.clinbiochem.2009.09.017

Cited by 33 publications

(30 citation statements)

References 34 publications

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“…In particular, the consumption of 500 g of strawberries daily for 9 days had no effect on circulating phenolics and plasma NEAC, whereas it increased UA-independent NEAC and urinary metabolites of polyphenols [431]. Furthermore, it has been suggested that urinary UA-independent NEAC normalized for creatinine could provide more reliable information about the antioxidant status in children and adults with Down syndrome [429]. …”

Section: Measuring the Nonenzymatic Antioxidant Capacity In Body Fmentioning

confidence: 99%

Measurement and Clinical Significance of Biomarkers of Oxidative Stress in Humans

Marrocco

Altieri

Peluso

2017

Oxidative Medicine and Cellular Longevity

624

500

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Oxidative stress is the result of the imbalance between reactive oxygen species (ROS) formation and enzymatic and nonenzymatic antioxidants. Biomarkers of oxidative stress are relevant in the evaluation of the disease status and of the health-enhancing effects of antioxidants. We aim to discuss the major methodological bias of methods used for the evaluation of oxidative stress in humans. There is a lack of consensus concerning the validation, standardization, and reproducibility of methods for the measurement of the following: (1) ROS in leukocytes and platelets by flow cytometry, (2) markers based on ROS-induced modifications of lipids, DNA, and proteins, (3) enzymatic players of redox status, and (4) total antioxidant capacity of human body fluids. It has been suggested that the bias of each method could be overcome by using indexes of oxidative stress that include more than one marker. However, the choice of the markers considered in the global index should be dictated by the aim of the study and its design, as well as by the clinical relevance in the selected subjects. In conclusion, the clinical significance of biomarkers of oxidative stress in humans must come from a critical analysis of the markers that should give an overall index of redox status in particular conditions.

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Section: Measuring the Nonenzymatic Antioxidant Capacity In Body Fmentioning

confidence: 99%

Measurement and Clinical Significance of Biomarkers of Oxidative Stress in Humans

Marrocco

Altieri

Peluso

2017

Oxidative Medicine and Cellular Longevity

624

500

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“…Serum lipid resistance to oxidation has been found in subjects with DS (Nagyova et al, 2000) and a concomitant increase in serum uric acid was also observed by the same authors. In a previous study of our research group with a representative sample of the population used in this work, significant increase in urinary uric acid levels was found in children with DS (Campos et al, 2010). Thus, we proposed that similar levels of lipid oxidation biomarkers (15-F 2t -IsoP and TBARS) in DS and controls could be the result of a higher lipid resistance to oxidation in DS, due to higher levels of uric acid.…”

Section: Lipid Peroxidation Assessmentmentioning

confidence: 67%

“…Oxidative stress in children with DS has been investigated in a number of in vivo studies (Campos et al, 2010;Casado et al, 2007;Meguid et al, 2010;Jovanovic et al, 1998;Muchová et al, 2001;Pallardó et al, 2006;Praticò et al, 2000) and also in adults (Campos et al, 2011;Strydom et al, 2009), however urinary biomarkers of oxidative stress have been little studied and the set of markers measured in each work very limited. In addition, several oxidative stress biomarkers such as H 2 O 2 , advanced glycation end products (AGEs) or dityrosine (diTyr) as well as nitrosative stress biomarkers such as total nitrite and nitrate (NOx) have not been studied yet in urine samples of children with DS.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of urinary biomarkers of oxidative/nitrosative stress in children with Down syndrome

Campos¹,

Guzmán²,

López-Fernández³

et al. 2011

Life Sciences

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“…For example, in humans, the end product of purine metabolism is uric acid, which is an antioxidant that may be relevant to the oxidative stress associated with DS. Indeed, individuals with DS accumulate unusually high levels of uric acid in their blood [2], which may be important in aging, and in neurodegenerative diseases associated with aging and DS [3]. This may be due to trisomy of the GART gene, which encodes an enzyme that catalyzes 3 steps of de novo purine synthesis, or it may be due to abnormal processing of uric acid by the kidneys of individuals with DS, or perhaps some other unknown mechanism.…”

Section: What Defines a Ds Mouse Model?mentioning

confidence: 99%

The Use of Mouse Models for Understanding the Biology of Down Syndrome and Aging

Vacano

Duval

Patterson

2012

Current Gerontology and Geriatrics Research

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Down syndrome is a complex condition caused by trisomy of human chromosome 21. The biology of aging may be different in individuals with Down syndrome; this is not well understood in any organism. Because of its complexity, many aspects of Down syndrome must be studied either in humans or in animal models. Studies in humans are essential but are limited for ethical and practical reasons. Fortunately, genetically altered mice can serve as extremely useful models of Down syndrome, and progress in their production and analysis has been remarkable. Here, we describe various mouse models that have been used to study Down syndrome. We focus on segmental trisomies of mouse chromosome regions syntenic to human chromosome 21, mice in which individual genes have been introduced, or mice in which genes have been silenced by targeted mutagenesis. We selected a limited number of genes for which considerable evidence links them to aspects of Down syndrome, and about which much is known regarding their function. We focused on genes important for brain and cognitive function, and for the altered cancer spectrum seen in individuals with Down syndrome. We conclude with observations on the usefulness of mouse models and speculation on future directions.

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Urinary uric acid and antioxidant capacity in children and adults with Down syndrome

Cited by 33 publications

References 34 publications

Measurement and Clinical Significance of Biomarkers of Oxidative Stress in Humans

Measurement and Clinical Significance of Biomarkers of Oxidative Stress in Humans

Evaluation of urinary biomarkers of oxidative/nitrosative stress in children with Down syndrome

The Use of Mouse Models for Understanding the Biology of Down Syndrome and Aging

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