Urinary tungsten and incident cardiovascular disease in the Strong Heart Study: An interaction with urinary molybdenum

Nigra, Anne E.; Howard, Barbara V.; Umans, Jason G.; Best, Lyle G.; Francesconi, Kevin A.; Goessler, Walter; Devereux, Richard; Navas‐Acien, Ana

doi:10.1016/j.envres.2018.06.015

Cited by 23 publications

(12 citation statements)

References 36 publications

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“… 86 Moreover, urinary cadmium was associated with increased risk of ischemic stroke but had a more pronounced association in participants in the lowest tertile of serum Zn levels. 86 The few studies conducted to date have had the power to study effect modification between essential trace metals and toxic metals in reducing CVD risk.…”

Section: Epidemiological Studies Linking Metal Exposures To Cvd Riskmentioning

confidence: 96%

“…The available studies have also reported a significant association between imbalances in essential metals and CVD risk. Specifically, imbalanced levels of Zn, 20 , 21 Cu, 22–26 Cr, 27 , 28 Co, 29 , 30 Mg, 22 , 24 , 31–69 Se, 61 , 70–84 Ni, 85 and W 86–89 were associated with an increased CVD risk. Other studies, however, failed to establish a significant association between these essential metals and CVD risk 22 , 44 , 58 , 61 , 65 , 85 , 88 , 90–94 …”

Section: Epidemiological Studies Linking Metal Exposures To Cvd Riskmentioning

confidence: 99%

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Environmental heavy metals and cardiovascular diseases: Status and future direction

Yang

Zheng

et al. 2020

Chronic Diseases and Translational Medicine

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Cardiovascular disease (CVD) and environmental degradation are leading global health problems of our time. Recent studies have linked exposure to heavy metals to the risks of CVD and diabetes, particularly in populations from low- and middle-income countries, where concomitant rapid development occurs. In this review, we 1) assessed the totality, quantity, and consistency of the available epidemiological studies, linking heavy metal exposures to the risk of CVD (including stroke and coronary heart disease); 2) discussed the potential biological mechanisms underlying some tantalizing observations in humans; and 3) identified gaps in our knowledge base that must be investigated in future work. An accumulating body of evidence from both experimental and observational studies implicates exposure to heavy metals, in a dose-response manner, in the increased risk of CVD. The limitations of most existing studies include insufficient statistical power, lack of comprehensive assessment of exposure, and cross-sectional design. Given the widespread exposure to heavy metals, an urgent need has emerged to investigate these putative associations of environmental exposures, either independently or jointly, with incident CVD outcomes prospectively in well-characterized cohorts of diverse populations, and to determine potential strategies to prevent and control the impacts of heavy metal exposure on the cardiometabolic health outcomes of individuals and populations.

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Section: Epidemiological Studies Linking Metal Exposures To Cvd Riskmentioning

confidence: 96%

Section: Epidemiological Studies Linking Metal Exposures To Cvd Riskmentioning

confidence: 99%

Environmental heavy metals and cardiovascular diseases: Status and future direction

Yang

Zheng

et al. 2020

Chronic Diseases and Translational Medicine

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“…Secondary analyses were performed to explore whether the associations between arsenic exposure and the continuous measures of LV geometry and functioning were modified by sex, smoking status, BMI (<30, ≥30 kg/m 2 ), lipid treatment (no, yes), fasting glucose (normal, impaired), and BP (normal, prehypertension, or hypertension) by including interaction terms in linear regression models. In sensitivity analyses, we also further adjusted for tungsten and uranium, metals that tend to cooccur with arsenic in drinking water 31 and could be related to cardiovascular disease, 43,44 with similar findings (not shown). The data were analyzed using R software (version 3.0.3; R Development Core Team 2014).…”

Section: Methodsmentioning

confidence: 73%

Association of Arsenic Exposure With Cardiac Geometry and Left Ventricular Function in Young Adults

Pichler

Grau-Pérez

Téllez-Plaza

et al. 2019

Circ: Cardiovascular Imaging

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BACKGROUND: Arsenic exposure has been related to numerous adverse cardiovascular outcomes. The aim of this study was to investigate the cross-sectional and prospective association between arsenic exposure with echocardiographic measures of left ventricular (LV) geometry and functioning. METHODS: A total of 1337 young adult participants free of diabetes mellitus and cardiovascular disease were recruited from the SHFS (Strong Heart Family Study). The sum of inorganic and methylated arsenic concentrations in urine (ΣAs) at baseline was used as a biomarker of arsenic exposure. LV geometry and functioning were assessed using transthoracic echocardiography at baseline and follow-up. RESULTS: Mean follow-up was 5.6 years, and median (interquartile range) of ΣAs was 4.2 (2.8–6.9) μg/g creatinine. Increased arsenic exposure was associated with prevalent LV hypertrophy, with an odds ratio (95% CI) per a 2-fold increase in ΣAs of 1.47 (1.05–2.08) in all participants and of 1.58 (1.04–2.41) among prehypertensive or hypertensive individuals. Measures of LV geometry, including LV mass index, left atrial systolic diameter, interventricular septum, and LV posterior wall thickness, were positively and significantly related to arsenic exposure. Among measures of LV functioning, stroke volume, and ejection fraction were associated with arsenic exposure. CONCLUSIONS: Arsenic exposure was related to an increase in LV wall thickness and LV hypertrophy in young American Indians with a low burden of cardiovascular risk factors. The relationship was stronger in participants with prehypertension or hypertension, suggesting that potential cardiotoxic effects of arsenic might be more pronounced in individuals already undergoing cardiovascular adaptive mechanisms following elevated systemic blood pressure.

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“…More studies are required on other microminerals since they have been less considered and results remain controversial. Serum molybdenum levels have been associated with T2DM [137], whereas the relationship between tungsten and CVD incidence has proved to be molybdenum-dependent, which underlines the promising role of molybdenum exposure in the disease [138]. Selenium and iodine may be implicated in DM, although results of epidemiologic studies and animal experiments are unclear [139].…”

Section: Micronutrients 221 Micromineralsmentioning

confidence: 99%

Nutrients and Dietary Approaches in Patients with Type 2 Diabetes Mellitus and Cardiovascular Disease: A Narrative Review

et al. 2021

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Cardiovascular disease (CVD) is the most common cause of morbidity and mortality in developed countries. The prevalence of CVD is much higher in patients with type 2 diabetes mellitus (T2DM), who may benefit from lifestyle changes, which include adapted diets. In this review, we provide the role of different groups of nutrients in patients with T2DM and CVD, as well as dietary approaches that have been associated with better and worse outcomes in those patients. Many different diets and supplements have proved to be beneficial in T2DM and CVD, but further studies, guidelines, and dietary recommendations are particularly required for patients with both diseases.

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Urinary tungsten and incident cardiovascular disease in the Strong Heart Study: An interaction with urinary molybdenum

Cited by 23 publications

References 36 publications

Environmental heavy metals and cardiovascular diseases: Status and future direction

Environmental heavy metals and cardiovascular diseases: Status and future direction

Association of Arsenic Exposure With Cardiac Geometry and Left Ventricular Function in Young Adults

Nutrients and Dietary Approaches in Patients with Type 2 Diabetes Mellitus and Cardiovascular Disease: A Narrative Review

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