Urinary Tract Infections in the Elderly Population

Matthews, S. James; Lancaster, Jason W.

doi:10.1016/j.amjopharm.2011.07.002

Cited by 121 publications

(84 citation statements)

References 173 publications

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“…7 and these populations are at greater risk of Gram positive and polymicrobial UTI. 8,9 Current management of UTIs is usually empirical, without the use of a urine culture or susceptibility testing to guide therapy. During the past decade, Gram positive cocci isolates exhibited a remarkable ability to rapidly develop antibiotic resistance and it is of great concern.…”

Section: Introductionmentioning

confidence: 99%

Gram positive uropathogens and their antibiogram: Data analysis at a tertiary care hospital in Karnataka

2020

IJMR

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Introduction: Urinary tract infections (UTI) are one of the most common infections encountered in clinical settings, being amenable to easy diagnosis with established laboratory methods. However, in recent years, antibiotic resistance has become a major public health problem worldwide owing to the extensive and inappropriate use of antimicrobial agents. Objectives: 1. To determine the various Gram positive isolates causing urinary tract infections. 2. To determine the antibiotic susceptibility pattern of Gram positive cocci. Material and Methods: A cross sectional study was conducted at a private tertiary care hospital in Shivamogga district of Karnataka, using secondary data of Gram positive bacteria isolated from urine samples maintained in the Microbiology laboratory registers for a period of 1 year from January 2016 to December 2016. Standard protocols were followed for bacteria isolation, identification and to assess their antibiotic susceptibility. Statistical analysis was done using MS office Excel 2010. Results: Of the total 1254 urine specimens, 466 (37.16%) revealed positive cultures. Out of the 512 isolates from positive cultures, 196 (38.28%) were Gram positive bacteria. The predominant isolates i.e. 86 (43.87%) belonged to Enterococcus species. All the isolates were susceptible to Linezolid and Vancomycin. Majority i.e. 184 (93.87%) were sensitive to nitrofurantoin followed by gentamicin 146 (74.48%) and majority showed resistance to ampicillin i.e.126 (64.28%). Conclusion:The rise in the resistance among uropathogens alerts us against indiscriminate use of antibiotics, indicating the need to establish antibiotic policies along with stringent measures to ensure effectiveness of the same.

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Section: Introductionmentioning

confidence: 99%

Gram positive uropathogens and their antibiogram: Data analysis at a tertiary care hospital in Karnataka

2020

IJMR

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“…Their baseline body temperature is lower on average, and an increase from baseline temperature may be seen in an infection even if it does not meet the typical threshold for fever [17]. Additionally, atypical symptoms such as lethargy and anorexia have been reported in nursing home residents with UTIs [7]. The most common sign reported for UTIs is altered mental status which includes symptoms such as Bconfused, more irritable, crying, aggressive, agitated, and less compliant^ [26].…”

Section: Non-specific Presentation Of Signs and Symptomsmentioning

confidence: 99%

“…UTIs are the most commonly occurring infections in nursing home residents [7,8]. Risk factors for UTIs in nursing home residents include urinary catheter use, female gender, older age, incontinence, poor hygiene, and cognitive dysfunction [9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial Stewardship Strategies in Nursing Homes: Urinary Tract Infections

McDanel

Carnahan

2016

Curr Treat Options Infect Dis

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“…Proteus mirabilis is a Gram-negative bacteria which is an etiological cause of urinary tract infection (UTI), especially among the elderly inhabitants in nursing homes, patients with type 2 diabetes, people with a long period of catheterization, or postoperative [1,2]. P. mirabilis can cause different forms of UTI including cystitis, pyelonephritis, asymptomatic bacteriuria, bacteremia, urolithiasis and progression to potentially life-threatening urosepsis [2,3].…”

Section: Introductionmentioning

confidence: 99%

Bioinformatics analysis and expression of a truncated form of Proteus mirabilis Pta protein as a novel vaccine target against urinary tract infection

Choubini

Karam

Kazemi

et al. 2016

vacres

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Introduction: Pathogenic strains of Proteus mirabilis have important roles in urinary tract infection. Proteus toxic agglutinin (Pta) is amongst the most important virulence factors of P. mirabilis. This protein has a conserved sequence present in all the strains which could be evaluated as a novel vaccine target against them. The aims of the current study were the expression, purification and characterization of a truncated Pta protein of P. mirabilis strain HI4320 as well as the bioinformatics analysis of the truncated protein. Methods: The passenger domain of pta genes in P. mirabilis was evaluated by bioinformatics studies. The selected domain (residues 207-730) was amplified by PCR and cloned into pET28a expression vector. The Pta was expressed in BL21 (DE3) host and purified by Ni-NTA resin. The analyses of the purified protein were performed by SDS-PAGE and Western blotting. Results: The bioinformatics studies predicted the appropriateness of the passenger domain of Pta protein in terms of conservation, stability and cell-surface exposure. The length of PCR fragment of truncated form of pta gene was ~1500 bp. The cloning and expression of the truncated pta gene was successfully performed using pET28a-BL21 (DE3) system. Analyses of the purified Pta by SDS-PAGE and Western blotting confirmed the purification of a ~60 kDa His-tagged polypeptide. Conclusion: The high frequency of P. mirabilis infection, especially in patients with abnormalities in their urinary tracts and also the rising of antibiotic resistance among the strains of this pathogen point to the need for effective controlling measures against them. In this regard, the passenger domain of Pta could be considered as a vaccine target. The efficacy and in-vivo immunogenicity of this purified protein is currently under study.

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Urinary Tract Infections in the Elderly Population

Cited by 121 publications

References 173 publications

Gram positive uropathogens and their antibiogram: Data analysis at a tertiary care hospital in Karnataka

Gram positive uropathogens and their antibiogram: Data analysis at a tertiary care hospital in Karnataka

Antimicrobial Stewardship Strategies in Nursing Homes: Urinary Tract Infections

Bioinformatics analysis and expression of a truncated form of Proteus mirabilis Pta protein as a novel vaccine target against urinary tract infection

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