Gram positive uropathogens and their antibiogram: Data analysis at a tertiary care hospital in Karnataka

doi:10.18231/2394-5478.2018.0014

Cited by 3 publications

(1 citation statement)

References 10 publications

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“…In the case of gram negative organisms the resistance to Norfloxacin and cotrimoxazole was high and is 54% and 78% respectively. The resistance pattern observed in this study is similar to the study by Naik et al from Karnataka [27]. Drug resistance among uropathogens has increased over the past few decades because of their widespread indiscriminate use, easy availability, and over the counter sale.…”

Section: Original Research Articlesupporting

confidence: 88%

Bacterial pathogens causing UTI and their antibiotic sensitivity pattern: a study from a tertiary care hospital from South India

P.¹,

V.²

2019

Trop J Pathol Microbiol

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Objectives: This study was conducted to find out the prevalence of pathogens causing UTI and their antibiotic sensitivity pattern. Materials and Methods: A Prospective study was carried out in the department of Microbiology for one year period from January to December 2018collaboratingwith the various clinical departments to determine the spectrum of organisms causing urinary tract infections and to determine their antibiotic susceptibility profile. Results: Among the 8303 samples tested significant bacteriuria was observed in 33.14%. The incidence of UTI was more common in females and in the age group of 31-40 years. In this study, 1931 (70.6%) gram negative bacilli and 756 (27.4%) gram positive cocci were isolated, among which E.coli (61.2%) was the commonest followed by Klebsiella (18.90%), Pseudomonas (8.02 %), Acinetobacter (4.4%), Proteus (3.7%) and Citrobacter (3.72%). Among the gram positive organisms Entetrococcus (87.4%) was the highest followed by Coagulase negative staphylococcusaureus (CONS) (7.9%) and Staphlococcus aureus (4.6%). Candida was isolated in 65cases (2.3%). Imipenem (100%) was the most susceptible antibiotic for Enterobacteriaciae followed by levofloxacin (83%) and Amikacin (82%). For the gram positive organisms Vancomycin (100%) and Linezolid (100%) was the most susceptible antibiotic followed by Nitrofurantoin (80%) and Gentamycin (60%). For both the gram positive and the gram negative organisms Nalidicacid, Norfloxacin, Cotrimoxazole and ampicillin were highly resistant and showed less than 30%sensitivity. Conclusion: Knowledge of the pattern of organisms causing UTI and their sensitivity pattern is important in choosing empirical drugs in the treatment of UTI.

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Section: Original Research Articlesupporting

confidence: 88%

Bacterial pathogens causing UTI and their antibiotic sensitivity pattern: a study from a tertiary care hospital from South India

P.¹,

V.²

2019

Trop J Pathol Microbiol

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Recent trends in uropathogenic infections in patients of a tertiary care center, New Delhi, India, – a topic of urgent attention

Gupta

Sharma

2023

Microbiology Independent Research Journal (MIR Journal)

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Urinary tract infections (UTIs) are the leading cause of outpatient visits and nosocomial infections worldwide resulting in increased healthcare costs. Information about the disease-associated pathogens and their susceptibility profile is of paramount importance for choosing antimicrobials and containing the alarming rise in microorganisms’ drug resistance. This study aimed to investigate the prevalence of gram-negative and gram-positive uropathogens in hospitalized adult patients, considering their sensitivity profile. The study retrospectively analyzed 2099 urine samples received from December 2019 to May 2020. The isolates were identified by standard microbiological methods, and sensitivity testing was done following the Clinical and Laboratory Standards Institute (CLSI) guidelines (2019). Out of the 2099 samples tested, 212 were positive. The vast majority of samples (97.6%) was received from women. Escherichia coli (34.9%) was the most common gram-negative pathogen, while Enterococcus spp. (15.1%) prevailed among gram-positive organisms. Among gram-negative organisms, a high susceptibility was observed for aminoglycosides (amikacin, netilmicin), nitrofurantoin, and carbapenems, while a high resistance was found towards co-trimoxazole, fluoroquinolones, and cephalosporins. We confirmed that nitrofurantoin, a traditional oral drug, still demonstrates good activity against uropathogens. Thus, there is an urgent need to study uropathogens and their susceptibility patterns to control the inadvertent use of antimicrobials and the spread of multidrug-resistant strains.

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Multidrug Resistant Bacteria in Urinary Tract Infection: A Constant Threat to a Tertiary Care Health Set-up in North India

Kaira¹,

Khan²

2014

Journal of Medical Academics

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Introduction: Urinary tract infections (UTIs) is one of the most common bacterial infections. Irrelevant use of antibiotics has resulted in the emergence of resistant strains. Aims and objective:To identify and look for the antimicrobial resistance pattern of various isolates in a tertiary care teaching hospital.Methods: A retrospective study was conducted in a tertiary level hospital for 4 years (March 2014to March 2018. A total of 41020 urine samples received in the laboratory and 6114 of them diagnosed to be culture positive UTI were processed for Antibiotic sensitivity by the standard microbiological procedure.Results: Out of 6114 culture, positive samples 2829 (46.27%) had significant bacteriuria. Females more affected (52.27%) than males (48.43%). Amongst fermenters (GNF), E.coli (52.7%) was most common followed by Klebsiella spp. (23.65%). Amongst the Gram-positive organisms Enterococcus spp. (3.67%) was more common followed by Staphylococcus saprophyticus (1.44%). While Pseudomonas spp. followed by Burkholderia sp were the common non-fermenters (GNNF). In GNF, imipenem, meropenem and amikacin were most effective drugs whereas, in GNNF, imipenem, meropenem and piperacillin-tazobactam were more effective. Linezolid and vancomycin were the most sensitive antibiotics in Gram-positive isolates. Conclusion:There is increasing resistance to, and nitrofurantoin noted in our study that is frequently considered drugs of choice for empiric therapy. It is important to determine trends in antimicrobials susceptibilities, to formulate local antibiotics policy that will guide the clinicians regarding the empirical choice for UTI to prevent misuse or overuse of antibiotics.Clinical significance: Because of the emerging resistance to the available group of antimicrobials, regular monitoring of the resistance pattern is essential for the clinicians to choose for the best empiric therapy.

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Gram positive uropathogens and their antibiogram: Data analysis at a tertiary care hospital in Karnataka

Cited by 3 publications

References 10 publications

Bacterial pathogens causing UTI and their antibiotic sensitivity pattern: a study from a tertiary care hospital from South India

Bacterial pathogens causing UTI and their antibiotic sensitivity pattern: a study from a tertiary care hospital from South India

Recent trends in uropathogenic infections in patients of a tertiary care center, New Delhi, India, – a topic of urgent attention

Multidrug Resistant Bacteria in Urinary Tract Infection: A Constant Threat to a Tertiary Care Health Set-up in North India

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