Urinary tract infections in hospital pediatrics: Many previous antibiotherapy and antibiotics resistance, including fluoroquinolones

Garraffo, Aurélie; Marguet, C.; Checoury, A; Boyer, Sophie; Gardrat, A; Houivet, Estelle; Caron, François

doi:10.1016/j.medmal.2013.12.002

Cited by 18 publications

(12 citation statements)

References 16 publications

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“…The low frequency of ESBL-producing enterobacteria (1.1%) and the elevated susceptibility of enterococci to the studied antibiotics would contribute to the higher bacterial susceptibility rates in the children. As observed by various authors, increased resistance rates are associated with greater exposure to antibiotics [4, 22, 23], and the lesser exposure of infants in comparison to adults may also explain the increased susceptibility of UTI isolates in the pediatric population.…”

Section: Discussionmentioning

confidence: 92%

“…In most countries, resistance to cotrimoxazole and aminoglycosides, especially in Enterococcus spp. but also in Enterobacteriaceae , is now so high that they are no longer suitable for empiric UTI treatment in young children [4, 11, 23]. In their place, cephalosporins have become the empiric drug of choice, but uropathogen resistance to cephalosporins is also increasing [4].…”

Section: Discussionmentioning

confidence: 99%

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Etiological and Resistance Profile of Bacteria Involved in Urinary Tract Infections in Young Children

Sorlózano-Puerto

Gómez-Luque

Luna

et al. 2017

BioMed Research International

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Background. The objective of this study was to identify the bacteria most frequently responsible for urinary tract infection (UTI) in the population of under-2-year-olds in our geographic area and to evaluate the activity of antibiotics widely used for UTI treatment during a 4-year study period. Materials and Methods. A retrospective analysis was conducted of data on the identification and susceptibility of microorganisms isolated in urine samples from children under 2 years of age. Results. A total of 1,045 uropathogens were isolated. Escherichia coli accounted for the majority (60.3%) of these, followed by Enterococcus faecalis (22.4%) and Klebsiella spp. (6.5%). The highest E. coli susceptibility rates (>90%) were to piperacillin-tazobactam, cefuroxime, cefotaxime, ceftazidime, imipenem, gentamicin, nitrofurantoin, and fosfomycin, and the lowest were to amoxicillin-clavulanic acid and cotrimoxazole. Among all bacteria isolated, we highlight the overall high activity of piperacillin-tazobactam, imipenem, nitrofurantoin, and fosfomycin against both community and hospital isolates and the reduced activity of amoxicillin-clavulanic acid, cephalosporins, gentamicin, and cotrimoxazole. There was no significant change in the total activity of any of the studied antibiotics over the 4-year study period. Conclusion. Empiric treatment with amoxicillin-clavulanic acid, cotrimoxazole, cephalosporins, and gentamicin may be inadequate due to their limited activity against uropathogens in our setting.

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Section: Discussionmentioning

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Etiological and Resistance Profile of Bacteria Involved in Urinary Tract Infections in Young Children

Sorlózano-Puerto

Gómez-Luque

Luna

et al. 2017

BioMed Research International

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“…In a study by Domiınguez et al (21), 5% of E. coli strains isolated from children were resistant to ciprofloxacin. Other studies in recent years have also documented isolates of quinolone-resistant Enterobacteriaceae in children (22,23). Reports from İran and other parts of the world demonstrated a significant correlation between the mutations in the chromosomal gyrA and parC genes and resistance to fluoroquinolones (24,25).…”

Section: Resistant Sensitivementioning

confidence: 99%

Evaluation of Resistance to Ciprofloxacin and Identification of Mutations in Topoisomerase Genes in Escherichia coli and Klebsiella pneumonia Isolated from Pediatric Urinary Tract Infections

Ghadiri¹,

Akya²,

Elahi³

et al. 2019

jpr

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The urinary tract infections (UTIs) are some of the most important diseases among children. The common UTI pathogens among children are the bacteria in the Enterobacteriaceae family, such as Escherichia coli and Klebsiella pneumonia (1). Despite the fact that beta-lactam antibiotics, cotrimoxazole and ampicillin are the first line of medicine for the experimental treatment of patients with UTI, there are reports of high resistance to these antibiotics

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“…Empirical antimicrobial administration is not without concerns because this practice may select for multidrug resistant (MDR) organisms, disturb normal flora and encourage colonization or infection . Historical use of antimicrobials has been shown to encourage development of bacterial resistance in human beings with UTIs, not only to the antimicrobial in use, but possibly to more than 1 class of antimicrobials, highlighting the importance of the correct selection of an antimicrobial to treat a patient with a UTI …”

mentioning

confidence: 99%

“…6 Historical use of antimicrobials has been shown to encourage development of bacterial resistance in human beings with UTIs, not only to the antimicrobial in use, but possibly to more than 1 class of antimicrobials, highlighting the importance of the correct selection of an antimicrobial to treat a patient with a UTI. [7][8][9][10] Although guidelines for treating UTIs have been published for dogs and human beings, 3,11,12 regional variability exists among isolates as well as susceptibility to various antimicrobials. 10,13 The population of affected individuals can vary, with some hospitals treating more patients with uncomplicated UTIs, whereas others may see primarily patients with complicated UTIs.…”

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confidence: 99%

Antimicrobial Susceptibility Patterns in Urinary Tract Infections in Dogs (2010–2013)

Wong

Epstein

Westropp

2015

Veterinary Internal Medicne

112

115

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BackgroundUrinary tract infections (UTIs) are common in dogs. The responsible bacterial populations have evolved with increasing resistance to many antimicrobials.ObjectiveTo characterize the antimicrobial susceptibility patterns of canine urinary tract isolates over a 51‐month period.AnimalsOne thousand six hundred and thirty‐six bacterial isolates from 1,028 dogs.MethodsAerobic bacterial isolate growth and susceptibility data from urine cultures of dogs were identified, retrospectively. Medical records were reviewed to obtain signalment, comorbidities, and antimicrobial use in the previous 30 days. The UTIs were further categorized as uncomplicated, complicated, or pyelonephritis.ResultsCommon bacterial isolates identified were Escherichia coli (52.5%), Staphylococcus spp. (13.6%), and Enterococcus spp. (13.3%). In vitro susceptibility among all isolates varied for commonly prescribed antimicrobials (amoxicillin [59%], amoxicillin/clavulanic acid [76%], cephalexin [66%], enrofloxacin [74%] and trimethoprim‐sulfamethoxazole [86%]). For all antimicrobials tested (except aminoglycosides), in vitro susceptibility was higher in uncomplicated versus complicated infections (P < .05). Uncomplicated infection isolate susceptibility rates remained ≤90% for PO administered antimicrobials. Administration of amoxicillin, doxycycline, and enrofloxacin, but not amoxicillin/clavulanic acid in the previous 30 days was associated with resistance to that antimicrobial. Multidrug resistant isolates of E. coli and Staphylococcus spp. were more common in dogs with complicated than uncomplicated UTIs (36% versus 21%, P < .0001).Conclusions and Clinical ImportanceIn vitro susceptibility was highly variable and no PO administered antimicrobial had >90% efficacy among isolates tested. Multidrug resistance was frequent among isolates tested suggesting that routine culture and susceptibility testing is indicated. Previously prescribed antimicrobials may affect empirical choices made pending susceptibility testing.

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Urinary tract infections in hospital pediatrics: Many previous antibiotherapy and antibiotics resistance, including fluoroquinolones

Cited by 18 publications

References 16 publications

Etiological and Resistance Profile of Bacteria Involved in Urinary Tract Infections in Young Children

Etiological and Resistance Profile of Bacteria Involved in Urinary Tract Infections in Young Children

Evaluation of Resistance to Ciprofloxacin and Identification of Mutations in Topoisomerase Genes in Escherichia coli and Klebsiella pneumonia Isolated from Pediatric Urinary Tract Infections

Antimicrobial Susceptibility Patterns in Urinary Tract Infections in Dogs (2010–2013)

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