Urinary tract infection in diabetes: Susceptible organisms and antibiogram patterns in an outpatient clinic of a tertiary health care center

Bağır, Gülay Şimşek; Haydardedeoğlu, Filiz Ekşi; Çolakoğlu, Şule; Bakıner, Okan; Ozsahin, Kursad; Ertörer, Melek Eda

doi:10.5455/medscience.2019.08.9103

Cited by 7 publications

(15 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the presence of co morbidities (DM), MDR isolates as a leading etiological factor (Bagir et al, 2019;Nigussie & Amsalu, 2017). MDR against more than two antimicrobial drugs was found in 96.66% of total isolates in our investigation, which contradicts findings about the incidence of MDR in DM patients.…”

Section: Discussioncontrasting

confidence: 96%

Prevalence and antibiotic sensitivity of uropathogens isolated from type-ii diabetic patients having urinary tract infection (UTI): A retrospective study from a rural tertiary care hospital

Priyadarshini

Shah

Patadia

et al. 2022

ijhs

View full text Add to dashboard Cite

Background: Patients with Diabetes Mellitus are more prone to Urinary tract infection (UTI) than non-diabetic patients. Diabetes Mellitus has certain negative effects on the genital system and increases the incidence of urinary tract infection in diabetic patients. Design: Record based retrospective study. Methods: Records of patients with type-II diabetes having symptoms of UTI were reviewed from August 2021 to January 2022. Result: Out of 210 diabetic patients, the UTI rate was higher in females 59% than male 41%. The most common agents for causing UTI were E.coli followed by Pseudomonas aeruginosa, Klebsiella spp., Candida albicans and Candida non-albicans, Enterococcus, S.aureus and other organisms. About 70.68% Gram-negative isolates were resistant against ampicillin, 75.17% resistant against gentamycin, and 48.16% resistant against amoxicillin-clavulanic acid. Gram-positive isolates were 83.33% resistant against penicillin and 83.33% resistant against ciprofloxacin. However, both gram-negative and gram-positive were susceptible to nitrofurantoin. The overall multidrug resistance was observed in 201 out of 210 (95.71%) bacterial and candiduria isolates, while 3.33% of the isolates were resistant to one only antibiotic. Conclusion: Most common etiological agent is E.coli with high drug resistance to ampicillin and susceptible to nitrofurantoin. Therefore, performing urine culture and regular monitoring of UTI is essential.

show abstract

Section: Discussioncontrasting

confidence: 96%

Prevalence and antibiotic sensitivity of uropathogens isolated from type-ii diabetic patients having urinary tract infection (UTI): A retrospective study from a rural tertiary care hospital

Priyadarshini

Shah

Patadia

et al. 2022

ijhs

View full text Add to dashboard Cite

show abstract

“…4,5 Diabetes patients are more susceptible to contracting UTI if glucose is not well controlled, diabetes has already attacked the nervous system (neuropathy), it occurs among women, the patient already had kidney or blood vessel complications from diabetes, or the patient has had a urinary tract infection within the last year. [6][7][8][9] UTIs in diabetic patients may be symptomatic or asymptomatic bacteriuria, and are most commonly considered as intricate and complicated. 10 Asymptomatic UTI is the most common form in diabetic patients and can lead to severe kidney damage and renal failure.…”

Section: Introductionmentioning

confidence: 99%

“…7,9,12,18 Due to different reasons, these bacterial uropathogens showed wide-ranging resistances to different classes of antibiotics across the world. 6,7, In diabetic patients, early diagnosis of UTI is essential for its proper management and to avoid the incidence of possible complications. However, in developing countries including Ethiopia, urine culture screening is not routinely done for diabetic follow-ups; and treatment is empirical, which may lead to the emergence and spread of antimicrobial-resistant strains which is a leading cause of treatment failure in UTI.…”

Section: Introductionmentioning

confidence: 99%

<p>Bacterial Profiles and Their Associated Factors of Urinary Tract Infection and Detection of Extended Spectrum Beta-Lactamase Producing Gram-Negative Uropathogens Among Patients with Diabetes Mellitus at Dessie Referral Hospital, Northeastern Ethiopia</p>

Alemu¹,

Belete²,

Gebre-Selassie³

et al. 2020

DMSO

View full text Add to dashboard Cite

Purpose: To determine the bacterial profile with its associated risk factors and to identify extended spectrum beta-lactamase producing Gram-negative bacterial uropathogens among diabetic patients at Dessie Referral Hospital, Northeastern Ethiopia. Materials and Methods: A hospital-based cross-sectional study was conducted from May to September 2018. A total of 336 diabetic patients were included using a simple random sampling technique. A structured questionnaire was used to collect socio-demographic and risk factor-related data. A 10-mL mid-stream urine specimen was collected and transported to the microbiology laboratory for culture, antimicrobial susceptibility testing, and detection of ESBL-producing bacteria. The data were entered into SPSS version 22, and descriptive statistics, bivariate and multivariate logistic regression analyses were performed. A p-value ≤0.05 with a 95% confidence interval was considered for statistical significance. Results: Among 336 diabetic patients, the overall prevalence of UTI was 11.6%. The predominant bacterial isolate was Escherichia coli 12/39 (30.8%), followed by Klebsiella pneumoniae 11/ 39 (28.2%) and coagulase-negative staphylococci 7/39 (17.9%). Gram-negative isolates showed 100% resistance to ampicillin, whereas Gram-positive isolates showed a high level of resistance to penicillin and tetracycline. Moreover, MDR was observed among 18 (46.2%) of the isolates and 2 of the isolated Gram-negative bacteria were ESBL producers. Being illiterate (AOR=7.226, 95% CI: (1.478, 35.340), p<0.015), having current symptoms of UTI (AOR = 2.702, 95% CI: (1.102, 6.624), p=0.030), and blood glucose level ≥126 mg/dl (AOR = 2.940, 95% CI: (1.080, 8.005), p=0.035) were significantly associated with the occurrence of bacterial UTI. Conclusion: The overall prevalence of significant bacteriuria (11.6%) in this study was comparable with some studies in Ethiopia and relatively lower than others. A moderately higher rate of resistance to the commonly used antimicrobial agents was noticed for both Gram-negative and Gram-positive isolates. Health information dissemination should be given about UTI, glycemic control, and habit of drug use for diabetes mellitus patients.

show abstract

“…20 The main complication of diabetes reported by our patients was diabetic nephropathy (28.57%), similarly to that reported by Bagir et al (29.3%). 16 In this study, 25% of our patients had severe chronic renal failure. This is in line with the result reported by Ahmad's study (38.05%).…”

Section: Discussionmentioning

confidence: 99%

“…The female predominance of UTI is also widely reported by another authors. 16,17 It could be explained by the short length of the female urethra and the proximity of the urethral meatus to the vagina and anus, which favors the occurrence of UTI. 18 In our country, infections are still one of the main complications of diabetes mellitus.…”

Section: Discussionmentioning

confidence: 99%

Urinary tract infection in diabetics hospitalized in Befelatanana Hospital, Antananarivo: Epidemiological, clinical, biological profiles and risk factors for multidrug‐resistant bacterial infection

Raherison,

Raharinavalona,

Razanamparany

et al. 2023

Clinical Case Reports

View full text Add to dashboard Cite

Key Clinical MessageThe main type of urinary tract infection in hospitalized diabetics in Antananarivo is acute pyelonephritis; Escherichia coli is the most isolated uropathogen; imipenem, amikacin, fosfomycin and ceftriaxone are the major antibiotics for which Escherichia coli retain good sensitivity; Type 2 diabetes is predictive factor for infection by multidrug resistant bacteria.AbstractThis study aimed to describe the epidemiological‐clinical profiles of diabetics hospitalized for bacterial urinary tract infections in the Endocrinology Department of Befelatanana Hospital, to identify the main bacteria responsible, their antibiotic sensitivity profile and the factors associated with multidrug‐resistant bacterial infection. A cross‐sectional study was conducted between March 2017 and March 2020 involving all diabetics hospitalized for documented community‐acquired bacterial urinary tract infection during this period. The hospital prevalence of urinary tract infections was 4.64%. The mean age of the patients was 59.06 ± 14.26 years and the sex ratio was 0.15. The main sign was fever (55.76%). The main clinical form was uncomplicated acute pyelonephritis (38.46%). Fifty‐seven bacterial uropathogens were isolated. The most frequent was Escherichia coli (77.19%). Escherichia coli was sensitive to ertapenem and nitrofurantoin in 100% of cases, to Amikacin in 97.5% of cases, to Fosfomycin in 94.4% of cases and to Ceftriaxone in 80.65% of cases. Thirteen patients were infected with multidrug‐resistant bacteria, all of them are extended‐spectrum beta‐lactamase‐producing Enterobacteriaceae. Only the type of diabetes was associated with multidrug‐resistant bacteria infection. The epidemiological‐clinical and biological characteristics of urinary tract infections in our diabetics are similar to those reported in the literature. Compliance with the rules of proper antibiotic use is imperative to limit the emergence and spread of multidrug‐resistant bacteria.

show abstract

Urinary tract infection in diabetes: Susceptible organisms and antibiogram patterns in an outpatient clinic of a tertiary health care center

Cited by 7 publications

References 0 publications

Prevalence and antibiotic sensitivity of uropathogens isolated from type-ii diabetic patients having urinary tract infection (UTI): A retrospective study from a rural tertiary care hospital

Prevalence and antibiotic sensitivity of uropathogens isolated from type-ii diabetic patients having urinary tract infection (UTI): A retrospective study from a rural tertiary care hospital

<p>Bacterial Profiles and Their Associated Factors of Urinary Tract Infection and Detection of Extended Spectrum Beta-Lactamase Producing Gram-Negative Uropathogens Among Patients with Diabetes Mellitus at Dessie Referral Hospital, Northeastern Ethiopia</p>

Urinary tract infection in diabetics hospitalized in Befelatanana Hospital, Antananarivo: Epidemiological, clinical, biological profiles and risk factors for multidrug‐resistant bacterial infection

Contact Info

Product

Resources

About