Urinary tract infection caused by  Enterobacteriaceae  and its relationship with vesicoureteral reflux

Álvarez, Manuel Díaz; Batista, Bárbara Acosta; Córdova, Rodolfo Pérez; Robledo, Ernesto Hernández

doi:10.1016/j.bmhime.2016.10.001

Cited by 4 publications

(5 citation statements)

References 30 publications

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“…Recurrent UTIs were identified in patients with vesical/subvesical malformation (PUV, ano-rectal malformation) or high-grade VUR and bilateral hydronephrosis in our study. Results are comparable with previous studies that proved lower urinary tract disorder (LUTD) and VUR as risk factors in developing recurrent UTIs [5,16,21,23].…”

Section: Discussionsupporting

confidence: 89%

“…Hydronephrosis was the most frequent defect in our study group (83.51%) caused by PUJO, UVJO, or VUR, the latter being confirmed in 28.57% of cases. In the literature, VUR was associated with an increased risk of non-E. coli UTI development [23]. In our study, it could not be established VUR as a risk factor for non-E. coli UTI (t-test p = 0.31), although 45.75% of all UTIs occurred in patients with VUR.…”

Section: Discussioncontrasting

confidence: 72%

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Antibiotic Resistance Patterns of Uropathogens Causing Urinary Tract Infections in Children with Congenital Anomalies of Kidney and Urinary Tract

Isac

Basaca²,

Olariu

et al. 2021

Children

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Background: Urinary tract infections (UTI) are common in children worldwide. Congenital anomalies of kidney and urinary tract (CAKUT) increase the risk of UTI and consequently antibiotic resistance. Antibiotic resistance represents an important public health issue worldwide. We aimed to evaluate the local trend in terms of bacterial uropathogen resistance in the western part of Romania in children with CAKUT and UTI. Methods: 252 children with CAKUT were admitted to our hospital over a five-year period. Of them, 91 developed at least one UTI episode, with a total number of 260 positive urine cultures. We collected data about age at diagnosis of CAKUT, sex, origin environment, type and side of CAKUT, number of UTIs, type of uropathogen, and uropathogens antibiotic resistance. Results: Distribution of uropathogens was Escherichia coli (38.84%), Klebsiella spp. (21.15%), Enterococcus spp. (15.76%), Proteus spp. (8.07%), Pseudomonas spp. (8.07%), Enterobacter spp. (2.3%), other Gram-negative bacteria (2.3%), and other Gram-positive bacteria (3.45%). High antibiotic resistance was detected for ampicillin, amoxicillin, and second-generation cephalosporins. Escherichia coli presented high resistance for cefepime and ceftriaxone. Pseudomonas spp. remained susceptible to amikacin, quinolones, and colistin. Vancomycin, teicoplanin, linezolid, and piperacillin/tazobactam remained effective in treating Gram-positive UTI. Conclusions: High antibiotic resistance was identified for frequently used antibiotics. Lower antibiotic resistance was observed for some broad-spectrum antibiotics. Understanding uropathogens’ antibiotic resistance is important in creating treatment recommendations, based on international guidelines, local resistance patterns, and patient particularities.

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Section: Discussionsupporting

confidence: 89%

Section: Discussioncontrasting

confidence: 72%

Antibiotic Resistance Patterns of Uropathogens Causing Urinary Tract Infections in Children with Congenital Anomalies of Kidney and Urinary Tract

Isac

Basaca²,

Olariu

et al. 2021

Children

View full text Add to dashboard Cite

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“…The causative organisms most commonly involved in UTIs are those found in the colonic bacterial flora, primarily E. coli, which may be because of their capacity to attach to the uroepithelium. However, other Enterobacterales are also common [16,75]. The high prevalence of E. coli was comparable to that reported in previous studies [16,65,67].…”

Section: Discussionsupporting

confidence: 88%

Determinants of urinary tract infection in hospitalized patients with acute ischemic stroke

Jitpratoom¹,

Boonyasiri

2023

BMC Neurol

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Background Stroke is a major cause of morbidity and mortality worldwide. Urinary tract infection (UTI) is a common post-acute ischemic stroke (AIS) complication. We assessed the incidence, determinant factors, infection characteristics, post-stroke complications, and outcomes of hospitalized AIS patients with UTI. Methods This retrospective cohort study included AIS patients admitted within 7 days of stroke onset. The patients were divided into the UTI group and the non-UTI (control) group. Clinical data were collected and compared between the groups. Results There were 342 AIS patients (31 with UTIs and 311 controls). The multivariate analysis showed that an initial National Institutes of Health Stroke Scale (NIHSS) score of ≥ 15 (odds ratio [OR] 5.00, 95% confidence interval [CI] 1.33–18.72) and Foley catheter retention (OR 14.10, 95% CI 3.25–61.28) were risk factors for UTI, whereas smoking (OR 0.08, 95% CI 0.01–0.50), an initial systolic blood pressure (SBP) of > 120 mmHg (OR 0.06, 95% CI 0.01–0.31), and statin use (OR 0.02, 95% CI 0.0006–0.42) were protective factors. Twenty cases (64.5%) were community-acquired and 11 cases (35.3%) were hospital-acquired. Ten patients (32.3%) had catheter-associated UTIs. The most common pathogen was Escherichia coli (13 patients, 41.9%). Post-stroke complications were significantly more common in the UTI group, including pneumonia, respiratory failure, sepsis, brain edema, seizure, symptomatic hemorrhagic transformation, congestive heart failure, atrial fibrillation with a rapid ventricular response, acute kidney injury, and hyponatremia. The median length of stay (LOS) in the UTI group was 12 days versus 3 days in the control group (p < 0.001). The median 3-month modified Rankin Scale score was higher (5 in UTI and 2 in control; p < 0.001) and the median 3-month Barthel Index was lower (0 in UTI and 100 in control; p < 0.001) in the UTI group than in the control group. Conclusions The risk factors for post-AIS UTI included severe stroke (NIHSS score ≥ 15) and urethral catheter indwelling. An initial SBP of > 120 mmHg and statin use were protective factors. The UTI group had significantly worse post-stroke complications, a longer LOS, and worse 3-month outcomes. Smoking was protective, which requires further investigation.

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“…Previous studies have identified a potential association between non- E. coli UTI and urological malformations ( 25 – 27 ). In a study conducted in Cuba, the presence of VUR was a significant risk factor for non- E. coli UTI ( 26 ). Pauchard et al ( 27 ) also showed UTI caused by non- E. coli is frequently associated with the presence of an anatomical malformation.…”

Section: Discussionmentioning

confidence: 99%

Clinical and Microbial Etiology Characteristics in Pediatric Urinary Tract Infection

Liu

Wei

et al. 2022

Front. Pediatr.

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BackgroundUrinary tract infection (UTI) is a common occurrence in children. UTI and urological malformations are intimately linked. However, whether urinary tract malformations affect the clinical features of pediatric UTI remains unclear. The purpose of this study was to characterize the clinical features and microbial etiology of UTI in children.MethodsWe retrospectively reviewed the records of 741 patients with UTI treated at the Chongqing Medical University Affiliated Children's Hospital between 2015 and 2020. Patients with and without urological malformations were compared using propensity score matching (PSM).ResultsEscherichia coli was the most common causative microorganism of UTI, accounting for 40.5% of infections. One hundred twenty-two patients (16.5%) had urological malformations. PSM identified 122 matched pairs of patients with or without urological malformations. The proportion of patients with UTI caused by atypical microorganisms was significantly higher in patients with urological malformations (P = 0.048). Children with urological malformations showed longer duration of intravenous antibiotic treatment (P = 0.010), higher cost of treatment (P < 0.001), and higher prevalence of recurrence (23.8 vs. 10.7%, P < 0.001), compared with the normal group.ConclusionChildren with urological malformations are more likely to develop UTI with atypical microorganisms. Appropriate imaging examination and urine culture are strongly recommended for the diagnosis and management of pediatric UTI.

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Urinary tract infection caused by Enterobacteriaceae and its relationship with vesicoureteral reflux

Cited by 4 publications

References 30 publications

Antibiotic Resistance Patterns of Uropathogens Causing Urinary Tract Infections in Children with Congenital Anomalies of Kidney and Urinary Tract

Antibiotic Resistance Patterns of Uropathogens Causing Urinary Tract Infections in Children with Congenital Anomalies of Kidney and Urinary Tract

Determinants of urinary tract infection in hospitalized patients with acute ischemic stroke

Clinical and Microbial Etiology Characteristics in Pediatric Urinary Tract Infection

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