Urinary tract infection by Aerococcus sanguinicola. An emerging opportunistic pathogen

Jiménez‐Guerra, Gemma; Lara-Oya, Ana; Martínez-Egea, I.; Navarro-Marí, José María; Gutiérrez‐Fernández, José

doi:10.1016/j.rceng.2018.04.004

Cited by 4 publications

(11 citation statements)

References 20 publications

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“…In addition, different bacteria from the urinary commensal microbiota, such as Corynebacterium glucuronolyticum, Streptococcus gallolyticus, Aerococcus sanguinicola , have been described as opportunistic uropathogens causing infections ( Jiménez-Guerra et al., 2018 ; Pereira-Pérez et al., 2019 ; Ruiz-Pino et al., 2019 ).…”

Section: Influence Of the Urinary Microbiome On Diseasementioning

confidence: 99%

Urinary Microbiome: Yin and Yang of the Urinary Tract

Pérez-Carrasco

Soriano‐Lerma

Soriano

et al. 2021

Front. Cell. Infect. Microbiol.

127

119

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The application of next generation sequencing techniques has allowed the characterization of the urinary tract microbiome and has led to the rejection of the pre-established concept of sterility in the urinary bladder. Not only have microbial communities in the urinary tract been implicated in the maintenance of health but alterations in their composition have also been associated with different urinary pathologies, such as urinary tract infections (UTI). Therefore, the study of the urinary microbiome in healthy individuals, as well as its involvement in disease through the proliferation of opportunistic pathogens, could open a potential field of study, leading to new insights into prevention, diagnosis and treatment strategies for urinary pathologies. In this review we present an overview of the current state of knowledge about the urinary microbiome in health and disease, as well as its involvement in the development of new therapeutic strategies.

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Section: Influence Of the Urinary Microbiome On Diseasementioning

confidence: 99%

Urinary Microbiome: Yin and Yang of the Urinary Tract

Pérez-Carrasco

Soriano‐Lerma

Soriano

et al. 2021

Front. Cell. Infect. Microbiol.

127

119

View full text Add to dashboard Cite

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“…It was detected in urine samples from nephrology patients thanks to the utilization of blood agar medium (see above). Another relevant genus is Aerococcus spp., highlighting the predominance of A. urinae and A. sanguinicola in elderly males with underlying urological disease, who are at higher risk of UTI from infrequent pathogens [ 28 ]. Nevertheless, its possible presence should also be considered in adolescents because the diagnosis is often delayed and potentially severe disease (e.g., pyelonephritis, bacteremia, endocarditis or peritonitis) can develop [ 29 ].…”

Section: Discussionmentioning

confidence: 99%

“…However, A. viridans has elevated minimum inhibitory concentration (MIC) values for penicillin and aminoglycosides, and resistance to vancomycin has been reported [ 33 , 34 ]. Both the review and our laboratory results evidence elevated MICs for nitrofurantoin, fluoroquinolones, and cotrimoxazole [ 28 ]. The susceptibility varies among species, and a susceptibility study is necessary before the selection of antibiotic.…”

Section: Discussionmentioning

confidence: 99%

Emerging Presence of Culturable Microorganisms in Clinical Samples of the Genitourinary System: Systematic Review and Experience in Specialized Care of a Regional Hospital

Rosales-Castillo

Jiménez‐Guerra

Ruiz-Gómez

et al. 2022

JCM

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The detection of emerging pathogens responsible for genitourinary infections has increased with technological advances. We conducted a systematic review of publications on the involvement of these microorganisms in genitourinary samples, and we also investigated their presence and antibiotic susceptibility in samples from patients at our regional hospital (Granada, Spain). The MEDLINE database was searched up to 31 December 2020, and a cross-sectional descriptive study was performed of results obtained in urine samples and genital exudates from January 2016 through December 2019. The review highlighted the frequent involvement of Neisseria meningitidis in genital infections, while the data on other microorganisms were consistent with findings in our patient series. The emerging microorganisms most often responsible for urinary tract infections were Streptococcus bovis (58.5%) and Gardnerella vaginalis (23.6%) in females, and S. bovis (32.3%), Aerococcus urinae (18.6%), and Corynebacterium spp. (16.9%) in males; those most frequently reported in genital infections were S. viridans (36.4%) in females and C. glucuronolyticum (32.2%) and G. vaginalis (35.6%) in males. In general, emerging pathogens are resistant to conventional antibiotics such as penicillin. However, there has also been an increase in beta-lactam resistance by the S. bovis group and Corynebacterium spp. The systematic review showed that emerging microorganisms are responsible for only a small percentage of genitourinary infections but are of major clinical interest, with a predominance of the S. bovis group, G. vaginalis, Lactobacillus spp., Aerococcus spp., and Corynebacterium spp. in urine samples and of G. vaginalis and C. glucuronolyticum in genital samples. Given the increasing resistance to antibiotics empirically prescribed in patients with genitourinary infections, it is recommended to create an antibiogram in all cases.

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“…35 Three members of the Aerococcaceae family were reported in cases of urosepsis, namely: Aerococcus sanguinicola, Aerococcus urinae, and Globicatella sanguinis .33,35,39 The genus Aerococcus includes seven distinct species, five of which are known to be human pathogens: A. christensenii, A. sanguinicola, A. urinae, A. urinaehominis, and A. viridians. 66 The first time that A. urinae was isolated from a urine sample of a patient with UTI was in 1984. 35 Although A. sanguinicola has not been frequently found in clinical specimens, 33 it is currently the second bacteria of the genus most often isolated in urine cultures, after A. urinae.…”

Section: Gram-positive Bacterial Infectionsmentioning

confidence: 99%

“…35 Although A. sanguinicola has not been frequently found in clinical specimens, 33 it is currently the second bacteria of the genus most often isolated in urine cultures, after A. urinae. 66 These species identification has been difficult, with probable several misdiagnoses. 34,66 Nevertheless, DNA sequencing usage increased significantly as a method for bacteria demonstration and identification.…”

Section: Gram-positive Bacterial Infectionsmentioning

confidence: 99%

Atypical pathogens in urinary tract infections: a systematic review

Lima¹,

Gonçalves²,

Amorim³

et al. 2022

JMEN

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Urinary tract infection [UTI] accounts for a significant portion of the worldwide infections, whose cause occurs predominantly through Gram-negative bacilli, followed by Gram-positive bacteria and fungi. However, a number of cases by atypical pathogens are increasing. Thus, a systematic review was carried out on UTIs caused by atypical/emerging agents, covering etiological, epidemiological, clinical and therapeutic aspects. The search conducted via PubMed database and 59 articles composed the final sample. The laboratory approaches reported have included uroculture with special media; molecular methods such as PCR, real-time PCR, and nucleic acid sequencing; and MALDI-TOF mass spectrometry. Pathogens found among bacteria, including Gram-negative bacilli, Gram-positive cocci, diphtheroids, Mycoplasmataceae members, actinomycetes, and Gram-variable coccobacilli; yeasts, molds and microsporidia; virus, including BK polyomavirus, HPV, CMV and HSV-2; and a protozoan, Trichomonas vaginalis. The risk factors appear to be associated with patients' intrinsic features, such as advanced age, female gender, chronic diseases, prostatic hyperplasia, immunocompromised, genitourinary tract alteration; or risky situations as long-term urinary catheter usage, urinary tract manipulation, cancer chemotherapy, alcoholism, prolonged use of antibiotics and risky sexual behavior. The difficulty in identifying these agents was also evident, due to their peculiar characteristics or the unavailability of more sophisticated methods in the laboratorial routines, which implicates in the clinical management. Therefore, it is important that the medical and the microbiology teams are aware of the possibility of these agents in order to assess the need for further testing. The importance of antimicrobial susceptibility tests is also emphasized because of these organisms’ different profiles.

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Urinary tract infection by Aerococcus sanguinicola. An emerging opportunistic pathogen

Cited by 4 publications

References 20 publications

Urinary Microbiome: Yin and Yang of the Urinary Tract

Urinary Microbiome: Yin and Yang of the Urinary Tract

Emerging Presence of Culturable Microorganisms in Clinical Samples of the Genitourinary System: Systematic Review and Experience in Specialized Care of a Regional Hospital

Atypical pathogens in urinary tract infections: a systematic review

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