Urinary steroid profile in early pregnancy after in vitro fertilization

Bíró, Ildikó; Bufa, Anita; Wilhelm, Ferenc; Mánfai, Zoltán; Kilár, Ferenc; Göcze, Péter M.

doi:10.1111/j.1600-0412.2012.01387.x

Cited by 2 publications

(2 citation statements)

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“…There are limited data reporting levels of F and E metabolites in pregnant women [ 13 – 15 ], some of which refers to spot urine only [ 14 ]. Others include women in the first weeks of pregnancy [ 15 ] or—like the study from 1980—concern only the tetrahydrometabolites of F and E assessed in samples from 6 patients [ 16 ]. To our best knowledge, the only analysis of the function of 11β-HSD1 in GH and PE was published more than 20 years ago and comprised small study population [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

Increased cortisol metabolism in women with pregnancy-related hypertension

et al. 2018

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PurposeThe diminished function of 11β-hydroxysteroid dehydrogenase 2 (11β-HSD2) was found in placentae from preeclamptic pregnancies. Here, we examine the overall maternal glucocorticoid balance in pregnancy-related hypertension. We aim to answer the question if the functions of primary enzymes involved in cortisol metabolism: 11β-HSD1 and 11β-HSD2 and 5-reductases (both 5α- and 5β) are altered in the course of hypertensive pregnancy.MethodsWe determined plasma and urinary cortisol and cortisone as well as their urinary tetrahydro- and allo-tetrahydrometabolites, both in free and conjugated forms in samples obtained from 181 Polish women in the third trimester of pregnancy. We compared steroid profiles in women with preeclampsia (PE), gestational hypertension (GH), chronic hypertension (CH) and in normotensives (controls).ResultsWe found significant differences in glucocorticoid balance in pregnancy-related hypertension. Plasma cortisol to cortisone was significantly lower in PE than in controls (3.00 vs. 4.79; p < 0.001). Increased function of renal 11β-HSD2 in PE and GH was manifested by significantly lower urinary free cortisol to cortisone ratio (0.169 and 0.206 vs. 0.277 in controls; p < 0.005). Markedly enhanced metabolism of cortisol was observed in pregnancy-related hypertension, with no significant alterations in CH, and the changes were more clearly expressed in PE than in GH.ConclusionsThe glucocorticoid balance in PE and GH is shifted towards decreasing cortisol concentration either due to intensified conversion to cortisone or enhanced production of tetrahydro and allo-tetrahydrometabolites.

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Section: Introductionmentioning

confidence: 99%

Increased cortisol metabolism in women with pregnancy-related hypertension

et al. 2018

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“…Due to the non-invasiveness and ease of collection, maternal urine represents a feasible matrix for large scale screening studies. For example, the steroid metabolite profile in maternal urine has been reported as a suitable diagnostic tool for identification of intrahepatic cholestasis of pregnancy [10], and Smith-Lemli-Opitz syndrome [11], as well as determining success of in vitro fertilization [12]. A recent study from our group gave also preliminary evidence that contractions may be predicted by studying steroid metabolites in urine [7].…”

Section: Introductionmentioning

confidence: 93%