Urinary speciated arsenic and depression among US adults

Rahman, Humairat H; Yusuf, Korede K; Niemann, Danielle; Dipon, Shahriar R.

doi:10.1007/s11356-020-08858-2

Cited by 30 publications

(6 citation statements)

References 24 publications

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“…A survey conducted on Italian schoolchildren found that urinary arsenic levels were linked to the emergence of depression, anxiety, somatic problems, and attention disorders [ 32 ]. In a US population study, it was discovered that elevated urinary arsenate acid levels may increase the risk of depression [ 33 ]. Furthermore, Dona Sinha’s research demonstrated a correlation between the incidence of neurobehavioral symptoms, depression, and chronic low-level arsenic exposure among Indian women of childbearing age [ 34 ].…”

Section: Discussionmentioning

confidence: 99%

Subchronic Arsenic Exposure Induces Behavioral Impairments and Hippocampal Damage in Rats

Chu,

Yang,

et al. 2023

Toxics

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This study investigated the effects of subchronic arsenic exposure on behavior, neurological function, and hippocampal damage in rats. Thirty-two male Wistar rats were divided into four groups and exposed to different concentrations of arsenic in their drinking water for 12 weeks, while weekly water intake and body weight were recorded. Various neurobehavioral tests were conducted, evaluating overall activity levels, exploratory behavior, short-term memory, spatial learning and memory, anxiety-like behavior, and depressive-like states. Arsenic levels in urine, serum, and brain tissue were measured, and histopathological analysis assessed hippocampal damage using hematoxylin and eosin staining. The results demonstrated that arsenic exposure did not significantly affect overall activity or exploratory behavior. However, it impaired short-term memory and spatial learning and memory functions. Arsenic-exposed rats exhibited increased anxiety-like behavior and a depressive-like state. Arsenic levels increased dose-dependently in urine, serum, and brain tissue. The histopathological examinations revealed significant hippocampal damage, including neuronal shrinkage, cell proliferation, irregular structure, disordered arrangement, and vacuolation. These findings emphasize the importance of understanding the impact of arsenic exposure on behavior and brain health, highlighting its potential neurological consequences.

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Section: Discussionmentioning

confidence: 99%

Subchronic Arsenic Exposure Induces Behavioral Impairments and Hippocampal Damage in Rats

Chu,

Yang,

et al. 2023

Toxics

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“…Arsenocholine and arsenobetaine are exceptions to the severe cytotoxicity of inorganic forms of arsenic [28]. Organic arsenic, including arsenobetaine, arsenocholine, and arsenosugars, is considered non-toxic to humans [2]. Seafood is the main source of organic arsenic.…”

Section: Discussionmentioning

confidence: 99%

“…Arsenic is a human carcinogen linked to bladder, skin, and lung cancers, skin lesions, and depression [1] [2]. Arsenic has also been associated with arsenicrelated cardiovascular disease suggesting that arsenic exposure leads to thrombosis and inflammation [3].…”

Section: Introductionmentioning

confidence: 99%

Association of Environmental Toxic Metals with High Sensitivity C-Reactive Protein: A Cross-Sectional Study

Rahman¹,

Niemann²,

Bugajski³

2021

ODEM

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Objective: Metals including arsenic, lead, mercury, and cadmium are toxic and can increase cardiovascular disease risk. High-sensitivity C-reactive protein (hs-CRP) is a biomarker for inflammation and cardiovascular risk. This study will evaluate the association between urinary speciated arsenic, cadmium, lead, and mercury and blood values of hs-CRP in the United States adult population. Methods: A cross-sectional study using the 2015-2016 NHANES dataset, conducting multivariate linear regressions to analyze selected urinary metals and links with serum hs-CRP. Results: The sample consisted of 780 adults. In adjusted models, arsenocholine was found to be protective of inflammation, whereas aresnous acid, which is an inorganic, toxic type of arsenic acid, was positively associated with hs-CRP (b = 2.53). Conclusion: Urinary arsenous acid is a significant predictor of hs-CRP which is a biomarker for CVD.

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“…Arsenic (As) is a naturally occurring element and known carcinogen linked to bladder, skin, and lung cancers in addition to ischemic heart disease, skin lesions, and depression [1] [2]. It is estimated that 4.8% of domestic well users or 2.1 million people have well arsenic levels greater than the US Environmental Protecting Agency (EPA) regulation (>10 μg/L) [3].…”

Section: Introductionmentioning

confidence: 99%

Arsenic Exposure and Association with Hepatitis E IgG Antibodies

Rahman¹,

Niemann²,

Singh³

2020

ODEM

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Arsenic is a known toxic chemical, has immuno-modulatory properties, and can change the susceptibility of infection in humans. Acute hepatitis E is an infectious disease; it can be self-limiting, but in severe cases, can cause acute-on-chronic liver failure. The presence of IgG anti-HEV (hepatitis E IgG antibody) in blood represents a past hepatitis E infection in an individual. Very few studies have investigated the association between arsenic levels and hepatitis E seroconversion in humans. The primary objective of this study was to assess the relationship between total urinary arsenic and speciated urinary arsenic (urinary arsenous acid, urinary arsenic acid, urinary arsenobetaine, urinary arsenocholine, urinary dimethylarsinic acid, urinary monomethylarsonic acid) and the presence of IgG anti-HEV.

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Urinary speciated arsenic and depression among US adults

Cited by 30 publications

References 24 publications

Subchronic Arsenic Exposure Induces Behavioral Impairments and Hippocampal Damage in Rats

Subchronic Arsenic Exposure Induces Behavioral Impairments and Hippocampal Damage in Rats

Association of Environmental Toxic Metals with High Sensitivity C-Reactive Protein: A Cross-Sectional Study

Arsenic Exposure and Association with Hepatitis E IgG Antibodies

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