Urinary semaphorin 3A as an early biomarker to predict contrast-induced acute kidney injury in patients undergoing percutaneous coronary intervention

Abstract

Contrast-induced acute kidney injury (CI-AKI) is a serious complication of diagnostic coronary angiograph and percutaneous coronary intervention (PCI). However, the exact pathophysiological mechanisms underlying CI-AKI development are largely unknown. The present study examined whether urinary semaphorin 3A levels predict the development of CI-AKI in patients undergoing PCI. This study enrolled 168 patients with stable angina undergoing elective PCI. Serial urine samples, obtained at baseline and 2, 6, 12, 24, 36, and 48 h post-PCI were analyzed by semaphorin 3A and neutrophil gelatinase-associated lipocalin (NGAL) ELISA kit. AKI was defined as an increase in serum creatinine beyond 50% according to the RIFLE classification system. Receiver operator characteristic (ROC) curve analyses identified optimal semaphorin 3A and NGAL values for diagnosing CI-AKI. CI-AKI occurred in 20 of 168 patients. There were no significant differences in the baseline clinical characteristics and angiographic findings between non-AKI patients group and AKI patients group. Both urinary semaphorin 3A and NGAL levels significantly increased at 2 and 6 h post-PCI. ROC analysis showed that the cut-off value of 389.5 pg/mg semaphorin 3A at 2 h post-PCI corresponds to 94% sensitivity and 75% specificity and the cut-off value of 94.4 ng/mg NGAL at 2 h post-PCI corresponds to 74% sensitivity and 82% specificity. Logistic regression showed that semaphorin 3A levels at 2 and 6 h post-PCI were the significant predictors of AKI in our cohort. Urinary semaphorin 3A may be a promising early biomarker for predicting CI-AKI in patients undergoing PCI.

Catalpol Protects Against High Glucose-Induced Bone Loss by Regulating Osteoblast Function

“…Therefore, activating the Wnt signaling inhibited by redundant sclerostin and accelerating osteoblast to further differentiation and maturation have positive effects on bone loss in diabetic osteoporosis. The effects of catalpol on bone formation and calcium deposition in BMSCs in vitro was partly via activation of upregulation of Wnt/β-catenin pathway ( Ning et al, 2018 ). There are several studies explaining the mechanism of catalpol on osteoblast.…”

Low Urine Secretion of Semaphorin3A in Lupus Patients with Proteinuria

“…Serial urine samples of sema3A were obtained at baseline and at intervals of 4 hours following percutaneous coronary intervention (PCI). Increased urine sema3A levels at 2 and 6 hours, post-PCI signi cantly predicted renal injury (9). The renal pathologies in which sema3A was evaluated were all related to a direct renal injury or persistent ischemia but not to immune-mediated injury.…”

Role of Semaphorin 3A in Kidney Development and Diseases

“…Finally, urinary SEMA3A was not increased in sepsis-induced AKI, while levels of other urinary biomarkers were increased [88,89]. An increase in urinary SEMA3A was also reported in contrast-induced acute kidney injury [63]. Among 168 patients who underwent percutaneous coronary intervention (PCI), 20 patients developed AKI.…”