Role of Semaphorin 3A in Kidney Development and Diseases

Sang, Yizhen; Tsuji, Kenji; Nakanoh, Hiroyuki; Fukushima, Kazuhiko; Kitamura, Shinji; Wada, Jun

doi:10.3390/diagnostics13193038

Cited by 2 publications

(3 citation statements)

References 106 publications

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“…Previously, NRP-1 has been associated with liver pathologies [39,41] and kidney disease [42][43][44][45]50,52,53]. Urinary NRP-1 has been proposed as a biomarker for lupus nephritis [42] due to its high expression in mesangial cells.…”

Section: Discussionmentioning

confidence: 99%

“…Interestingly, NRP-1 has also been found to be expressed in liver cells and appears to be upregulated in various liver-related pathologies [39][40][41]. Other diseases that have been studied include kidney injury [42][43][44][45], autoimmune disease [46,47], and neurological disorders [48,49]. However, there is a lack of data on NRP-1 in human sepsis, despite efforts to understand its role in sepsis and its connection to kidney failure [50][51][52][53][54][55][56].…”

Section: Introductionmentioning

confidence: 99%

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Soluble Neuropilin-1 Is Elevated in Sepsis and Correlates with Organ Dysfunction and Long-Term Mortality in Critical Illness

Hohlstein,

Schumacher,

Abu Jhaisha

et al. 2024

IJMS

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Critical illness and sepsis may cause organ failure and are recognized as mortality drivers in hospitalized patients. Neuropilin-1 (NRP-1) is a multifaceted transmembrane protein involved in the primary immune response and is expressed in immune cells such as T and dendritic cells. The soluble form of NRP-1 (sNRP-1) acts as an antagonist to NRP-1 by scavenging its ligands. The aim of this study was to determine the value of sNRP-1 as a biomarker in critical illness and sepsis. We enrolled 180 critically ill patients admitted to a medical intensive care unit and measured serum sNRP-1 concentrations at admission, comparing them to 48 healthy individuals. Critically ill and septic patients showed higher levels of sNRP-1 compared to healthy controls (median of 2.47 vs. 1.70 nmol/L, p < 0.001). Moreover, sNRP-1 was also elevated in patients with sepsis compared to other critical illness (2.60 vs. 2.13 nmol/L, p = 0.01), irrespective of disease severity or organ failure. In critically ill patients, sNRP-1 is positively correlated with markers of kidney and hepatic dysfunction. Most notably, critically ill patients not surviving in the long term (one year after admission) showed higher concentrations of sNRP-1 at the time of ICU admission (p = 0.036), with this association being dependent on the presence of organ failure. Critically ill and septic patients exhibit higher serum concentrations of circulating sNRP-1, which correlates to organ failure, particularly hepatic and kidney dysfunction.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Soluble Neuropilin-1 Is Elevated in Sepsis and Correlates with Organ Dysfunction and Long-Term Mortality in Critical Illness

Hohlstein,

Schumacher,

Abu Jhaisha

et al. 2024

IJMS

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“…This effect was attributed to KCNQ1OT1’s ability to sponge miR-23b-3p and enhance Sema3A expression, a direct target of miR-23b-3p. Targeting KCNQ1OT1 through NAT-based interventions could offer promise for addressing diabetes and related inflammatory disorders [ 46 ].…”

Section: Regulation Occurring After Transcriptionmentioning

confidence: 99%

Therapeutic potential of natural antisense transcripts and various mechanisms involved for clinical applications and disease prevention

Ali,

Khatoon,

Shao

et al. 2023

RNA Biology

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Antisense transcription, a prevalent occurrence in mammalian genomes, gives rise to natural antisense transcripts (NATs) as RNA molecules. These NATs serve as agents of diverse transcriptional and post-transcriptional regulatory mechanisms, playing crucial roles in various biological processes vital for cell function and immune response. However, when their normal functions are disrupted, they can contribute to human diseases. This comprehensive review aims to establish the molecular foundation linking NATs to the development of disorders like cancer, neurodegenerative conditions, and cardiovascular ailments. Additionally, we evaluate the potential of oligonucleotide-based therapies targeting NATs, presenting both their advantages and limitations, while also highlighting the latest advancements in this promising realm of clinical investigation. Abbreviations: NATs- Natural antisense transcripts, PRC1- Polycomb Repressive Complex 1, PRC2- Polycomb Repressive Complex 2, ADARs- Adenosine deaminases acting on RNA, BDNF-AS- Brain-derived neurotrophic factor antisense transcript, ASOs- Antisense oligonucleotides, SINEUPs- Inverted SINEB2 sequence-mediated upregulating molecules, PTBP1- Polypyrimidine tract binding protein-1, HNRNPK- heterogeneous nuclear ribonucleoprotein K, MAPT-AS1- microtubule-associated protein tau antisense 1, KCNQ1OT- (KCNQ1 opposite strand/antisense transcript 1, ERK- extracellular signal-regulated kinase 1, USP14- ubiquitin-specific protease 14, EGF- Epidermal growth factor, LSD1- Lysine Specific Demethylase 1, ANRIL- Antisense Noncoding RNA in the INK4 Locus, BWS- Beckwith-Wiedemann syndrome, VEGFA- Vascular Endothelial Growth component A

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Role of Semaphorin 3A in Kidney Development and Diseases

Cited by 2 publications

References 106 publications

Soluble Neuropilin-1 Is Elevated in Sepsis and Correlates with Organ Dysfunction and Long-Term Mortality in Critical Illness

Soluble Neuropilin-1 Is Elevated in Sepsis and Correlates with Organ Dysfunction and Long-Term Mortality in Critical Illness

Therapeutic potential of natural antisense transcripts and various mechanisms involved for clinical applications and disease prevention

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