Urinary pyrethroid metabolites among pregnant women in an agricultural area of the Province of Jiangsu, China

Qi, Xiaojuan; Zheng, Minglan; Wu, Chunhua; Wang, Guoquan; Feng, Chao; Zhou, Zhijun

doi:10.1016/j.ijheh.2011.12.003

Cited by 116 publications

(76 citation statements)

References 28 publications

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“…For 3-PBA, the CTEPP adults (0.3 ng/mL) had similar median urinary metabolite levels as study adults (0.2-0.4 ng/mL) in Canada, Germany, Japan, and Poland. However in China (Qi et al, 2012), the median adult urinary 3-PBA concentrations (1.0 ng/mL) were at least two times higher compared to study adults in the US and in other countries. The authors speculate that the higher urinary 3-PBA levels observed in these adults (pregnant women) may be due to the markedly increased use of pyrethroid insecticides in residential and agricultural settings in China (Qi et al, 2012).…”

Section: Discussionmentioning

confidence: 66%

Predictors of urinary levels of 2,4-dichlorophenoxyacetic acid, 3,5,6-trichloro-2-pyridinol, 3-phenoxybenzoic acid, and pentachlorophenol in 121 adults in Ohio

Morgan

2015

International Journal of Hygiene and Environmental Health

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Section: Discussionmentioning

confidence: 66%

Predictors of urinary levels of 2,4-dichlorophenoxyacetic acid, 3,5,6-trichloro-2-pyridinol, 3-phenoxybenzoic acid, and pentachlorophenol in 121 adults in Ohio

Morgan

2015

International Journal of Hygiene and Environmental Health

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“…A number of previous studies have measured 3-PBA and other metabolites in urine samples collected from both adults and children to assess pyrethroid exposure (Barr et al 2010; Fortin et al 2008; Heudorf and Angerer 2001; Lu et al 2006; Qi et al 2012). We found that 3-PBA levels in this urban Mexican population were similar to levels measured in pregnant women who participated in the NHANES during the same time period.…”

Section: Discussionmentioning

confidence: 99%

“…In a study of pregnant women (n=1149) living in Jiangsu Province, an agricultural area in China, the geometric mean 3-PBA concentration was 0.97 ng/mL (unadjusted for specific gravity) (Qi et al 2012). Children from agricultural regions of Nicaragua and Thailand have also been shown to have relatively high pyrethroid exposures (Panuwet et al 2009; Rodriguez et al 2012).…”

Section: Discussionmentioning

confidence: 99%

Urinary 3-phenoxybenzoic acid (3-PBA) levels among pregnant women in Mexico City: Distribution and relationships with child neurodevelopment

Watkins

Fortenberry

Sánchez

et al. 2016

Environmental Research

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Background In recent years, pyrethroid pesticide use has increased in Mexico, the United States, and elsewhere, resulting in extensive human exposure. There is growing concern that pregnant women may be a particularly vulnerable population, as in utero fetal exposure during critical periods of development could adversely affect long-term neurobehavioral function. Methods We measured maternal urinary 3-phenoxybenzoic acid (3-PBA) concentrations during the third trimester of pregnancy as a measure of in utero pyrethroid exposure to the fetus among participants in an established Mexico City birth cohort (n=187). In a subset of mothers, we measured 3-PBA during the first, second, and third trimester (n=21) to assess variability across pregnancy. We examined associations between third trimester 3-PBA concentrations and children’s scores on the Mental Development Index (MDI) and Psychomotor Development Index (PDI) from the Bayley Scales for Infant Development (BSID-IIS) at 24 and 36 months of age. Results 3-PBA was detected in 46% of all urine samples, with similar detection rates and geometric mean concentrations across pregnancy among the 21 participants who provided repeat samples. Participants in the medium and high 3-PBA categories (≥LOD) had lower MDI scores at 24 months compared to those in the low 3-PBA category (

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“…A consequence of the increased availability, usage and broad-spectrum applicability of 3-PBA is its widespread exposure among the general population. Recent evidences suggest that 3-PBA is the most frequently detected xenobiotic in human urine [3]–[11]. Moreover, it also possesses endocrine disrupting activity [12]–[14], and adversely affects reproductive function and sexual development as well as the immune system in men [15]–[20].…”

Section: Introductionmentioning

confidence: 99%

Degradation of 3-Phenoxybenzoic Acid by a Bacillus sp

Chen

Xiao

et al. 2012

PLoS ONE

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3-Phenoxybenzoic acid (3-PBA) is of great environmental concern with regards to endocrine disrupting activity and widespread occurrence in water and soil, yet little is known about microbial degradation in contaminated regions. We report here that a new bacterial strain isolated from soil, designated DG-02, was shown to degrade 95.6% of 50 mg·L−1 3-PBA within 72 h in mineral salt medium (MSM). Strain DG-02 was identified as Bacillus sp. based on the morphology, physio-biochemical tests and 16S rRNA sequence. The optimum conditions for 3-PBA degradation were determined to be 30.9°C and pH 7.7 using response surface methodology (RSM). The isolate converted 3-PBA to produce 3-(2-methoxyphenoxy) benzoic acid, protocatechuate, phenol, and 3,4-dihydroxy phenol, and subsequently transformed these compounds with a q max, K s and K i of 0.8615 h−1, 626.7842 mg·L−1 and 6.7586 mg·L−1, respectively. A novel microbial metabolic pathway for 3-PBA was proposed on the basis of these metabolites. Inoculation of strain DG-02 resulted in a higher degradation rate on 3-PBA than that observed in the non-inoculated soil. Moreover, the degradation process followed the first-order kinetics, and the half-life (t 1/2) for 3-PBA was greatly reduced as compared to the non-inoculated control. This study highlights an important potential application of strain DG-02 for the in situ bioremediation of 3-PBA contaminated environments.

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Urinary pyrethroid metabolites among pregnant women in an agricultural area of the Province of Jiangsu, China

Cited by 116 publications

References 28 publications

Predictors of urinary levels of 2,4-dichlorophenoxyacetic acid, 3,5,6-trichloro-2-pyridinol, 3-phenoxybenzoic acid, and pentachlorophenol in 121 adults in Ohio

Predictors of urinary levels of 2,4-dichlorophenoxyacetic acid, 3,5,6-trichloro-2-pyridinol, 3-phenoxybenzoic acid, and pentachlorophenol in 121 adults in Ohio

Urinary 3-phenoxybenzoic acid (3-PBA) levels among pregnant women in Mexico City: Distribution and relationships with child neurodevelopment

Degradation of 3-Phenoxybenzoic Acid by a Bacillus sp

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