Urinary Proteomics for Prediction of Preeclampsia

Carty, David; Siwy, Justyna; Brennand, Janet; Zürbig, Petra; Mullen, William; Franke, Julia; McCulloch, James W.; North, Robyn A.; Chappell, Lucy C; Mischak, Harald; Poston, Lucilla; Dominiczak, Anna F.; Delles, Christian

doi:10.1161/hypertensionaha.110.164285

Cited by 129 publications

(101 citation statements)

References 40 publications

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“…The study aimed to develop a proteomic biomarker pattern for the prediction of pre-eclampsia in otherwise healthy pregnant women and has been described in detail elsewhere 14 ; in brief 4643 low-risk pregnant women were recruited at their initial antenatal appointment in hospitals across the West of Scotland. The study originally was powered to recruit 100 pre-eclampsia cases; based on an estimated prevalence of 2.5% it aimed to recruit at least 4000 women.…”

Section: Methodsmentioning

confidence: 99%

Thyroid stimulating hormone (TSH) ≥2.5 mU/l in early pregnancy: Prevalence and subsequent outcomes

Carty

Doogan

Welsh

et al. 2017

European Journal of Obstetrics & Gynecology and Reproductiv

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ObjectiveThere remains controversy over how women with abnormal thyroid function tests in pregnancy should be classified. In this study we assessed the proportion of women with thyroid stimulating hormone (TSH) ≥2.5mU/l in a large obstetric cohort, and examined how many have gone on to develop thyroid disease in the years since their pregnancy.Study Design 4643 women were recruited and samples taken in early pregnancy between 2007 and 2010. Thyroid function tests were analysed in 2014; in women with raised TSH computerised health records and prescription databases were used to identify thyroid disease detected since pregnancy.Results 58 women (1.5%) had a TSH over 5mU/l and 396 women (10.3%) had TSH between 2.5 and 5mU/l.Women with TSH>5mU/l delivered infants of lower birthweight than those with TSH<2.5mU/l; there were no other differences in obstetric outcomes between the groups. Of those who have had thyroid tests since their pregnancy, 78% of those with TSH>5mU/l and 19% of those with TSH between 2.5 and 5mU/l have gone on to be diagnosed with thyroid disease. ConclusionsUsing a TSH cut-off of 2.5mU/l in keeping with European and US guidelines means that over 12% of women in this cohort would be classified as having subclinical hypothyroidism. Treatment and monitoring of these women would have major implications for planning of obstetric services.

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Section: Methodsmentioning

confidence: 99%

Thyroid stimulating hormone (TSH) ≥2.5 mU/l in early pregnancy: Prevalence and subsequent outcomes

Carty

Doogan

Welsh

et al. 2017

European Journal of Obstetrics & Gynecology and Reproductiv

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“…4,5 Meanwhile, proteomic, metabolomic, and gene expression profiling of maternal plasma, urine, or peripheral blood mononuclear cells have been applied to search for new biomarkers and potential pathogenetic pathways. 40 It should be acknowledged that these techniques are not suited for simple, low-cost routine clinical prediction of preeclampsia but for the identification of new biomarkers.…”

Section: New Developmentsmentioning

confidence: 99%

Differential Diagnosis of Preeclampsia

et al. 2012

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“…Urinary angiotensinogen has been found downregulated in women with preeclampsia pointing toward the critical role of the RAAS in the development of this condition. Carty et al [86] conducted a CE-MS-based study and described urinary proteomic profiles in first trimester that were different between women who later developed preeclampsia and those who continued to be normotensive; the initial discoveries were, however, not validated in an independent validation cohort.…”

Section: Human Studiesmentioning

confidence: 99%

Utilizing proteomics to understand and define hypertension: where are we and where do we go?

Delles

Carrick

Graham

et al. 2018

Expert Review of Proteomics

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Introduction: Hypertension is a complex and multifactorial cardiovascular disorder. With different mechanisms contributing to a different extent to an individual’s blood pressure, the discovery of novel pathogenetic principles of hypertension is challenging. However, there is an urgent and unmet clinical need to improve prevention, detection, and therapy of hypertension in order to reduce the global burden associated with hypertension-related cardiovascular diseases.Areas covered: Proteomic techniques have been applied in reductionist experimental models including angiotensin II infusion models in rodents and the spontaneously hypertensive rat in order to unravel mechanisms involved in blood pressure control and end organ damage. In humans proteomic studies mainly focus on prediction and detection of organ damage, particularly of heart failure and renal disease. While there are only few proteomic studies specifically addressing human primary hypertension, there are more data available in hypertensive disorders in pregnancy, such as preeclampsia. We will review these studies and discuss implications of proteomics on precision medicine approaches.Expert commentary: Despite the potential of proteomic studies in hypertension there has been moderate progress in this area of research. Standardized large-scale studies are required in order to make best use of the potential that proteomics offers in hypertension and other cardiovascular diseases.

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Urinary Proteomics for Prediction of Preeclampsia

Cited by 129 publications

References 40 publications

Thyroid stimulating hormone (TSH) ≥2.5 mU/l in early pregnancy: Prevalence and subsequent outcomes

Thyroid stimulating hormone (TSH) ≥2.5 mU/l in early pregnancy: Prevalence and subsequent outcomes

Differential Diagnosis of Preeclampsia

Utilizing proteomics to understand and define hypertension: where are we and where do we go?

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