Urinary polycyclic aromatic hydrocarbon metabolites among 3-year-old children from Krakow, Poland

Sochacka-Tatara, Elżbieta; Majewska, Renata; Perera, Frederica P.; Camann, David; Spengler, John D.; Wheelock, Kylie; Sowa, Agata; Jacek, Ryszard; Mróz, Elżbieta; Pac, Agnieszka

doi:10.1016/j.envres.2018.02.032

Cited by 32 publications

(17 citation statements)

References 40 publications

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“…1-Pyr is a commonly used urinary biomarker of PAHs exposure. The urinary concentrations of 1-Pyr measured in this study (median: 0.38 ng/mL; 0.28 μg/g creatinine) were comparable to those reported from Poland (median: 0.36 μg/g creatinine) ( Sochacka-Tatara et al 2018 ), but higher than those reported from the United States (mean/median: 0.11–0.13 ng/mL) ( CDC 2019 ), Canada (mean/median: 0.09–0.11 ng/mL) ( Health Canada 2017 ), Czech Republic (median: 0.18 μg/g creatinine) ( Urbancova et al 2017 ), and Australia (0.06–0.14 ng/mL) ( Thai et al 2020 ; Thai et al 2015 ), and an order of magnitude lower than those reported from China (mean/median: 3.1–6.4 μg/g creatinine) ( Cao et al 2020a ; Li et al 2015a ).…”

Section: Resultssupporting

confidence: 83%

Variability in urinary biomarkers of human exposure to polycyclic aromatic hydrocarbons and its association with oxidative stress

Zhu

Martinez-Moral

Kannan

2021

Environment International

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Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous environmental pollutants. Urinary concentrations of mono-hydroxylated metabolites of PAHs (OH-PAHs) have been used as biomarkers of these chemicals’ exposure in humans. Little is known, however, with regard to intra- and inter-individual variability in OH-PAH concentrations and their association with oxidative stress. We conducted a longitudinal study of measurement of urinary concentrations of 15 OH-PAHs and 7 oxidative stress biomarkers (OSBs) of DNA damage [8-hydroxy-2′-deoxyguanosine (8-OHdG)], lipid [malondialdehyde (MDA) and F 2 -isoprostanes (PGF 2α )] and protein [ o,o ′ -dityrosine (diY)] peroxidation in 19 individuals for 44 consecutive days. Metabolites of naphthalene (OHNap), fluorene (OHFlu), phenanthrene (OHPhe), and pyrene (OHPyr) were found in >70% of 515 urine samples analyzed, at sum concentrations (∑OH-PAH) measured in the range of 0.46–60 ng/mL. After adjusting for creatinine, OHNap and ∑OH-PAH concentrations exhibited moderate predictability, with intra-class correlation coefficients (ICCs) ranging from 0.359 to 0.760. However, ICC values were low (0.001–0.494) for OHFlu, OHPhe, and OHPyr, which suggested poor predictability for these PAH metabolites. Linear mixed-effects analysis revealed that an unit increase in ∑OH-PAH concentration corresponded to 4.5%, 5.3%, 20%, and 21% increase in respective urinary 8-OHdG, MDA, PGF 2α , and diY concentrations, suggesting an association with oxidative damage to DNA, lipids, and proteins. The daily intakes of PAHs, calculated from urinary concentrations of OH-PAHs, were 10- to 100-fold below the current reference doses. This study provides valuable information to design sampling strategies in biomonitoring studies and in assigning exposure classifications of PAHs in epidemiologic studies.

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Section: Resultssupporting

confidence: 83%

Variability in urinary biomarkers of human exposure to polycyclic aromatic hydrocarbons and its association with oxidative stress

Zhu

Martinez-Moral

Kannan

2021

Environment International

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“…Most of the available studies from other countries were performed in Germany (21%), France (17%), Italy (10%), Poland (10%), Spain (7.0%), Belgium (7.0%), and the Czech Republic (7.0%); the remaining studies (one per country; 21% in total) were conducted in Denmark, Finland, Ukraine, the United Kingdom, and Sweden. Overall, median levels of total urinary PAH metabolites found for the Portuguese population (except for firefighters participating in firefighting activities) were lower than the concentrations reported for non-occupationally exposed populations (3.80 × 10 −2 µmol/mol creatinine in French non-smoking adults [ 32 ] to 13.8 µmol/mol creatinine in Polish young children [ 33 ]; 0.180 µg L −1 in Belgian adolescents [ 25 ] to 12.2 µg L −1 in German smoking adults [ 34 ]) and occupationally exposed groups (0.17 µmol/mol creatinine in French non-smoking metallurgy workers [ 35 ] to 28.6 µmol/mol creatinine in German converter workers [ 36 ]; 6.41 µg L −1 in Slovakian steel workers from a control group [ 37 ] to 155.1 µg L −1 in Polish coke-oven smoking workers [ 38 ]). People who were occupationally exposed to PAHs and/or had regular smoking habits presented higher concentrations of urinary PAH metabolites.…”

Section: Selected Chemicalsmentioning

confidence: 98%

“…Among the compounds under study within the Portuguese population, 1-hydroxynapthalene and 1-hydroxyacenaphthene were by far the most predominant metabolites, being followed by 2-hydroxyfluorene, 1-hydroxyphenanthrene, and 1-hydroxypyrene ( Table 1 ). Indeed, whenever metabolites of naphthalene (1-hydroxynaphthalene and/or 2-hydroxynaphthalene) were included in the HBM studies, they contributed the most to the levels of total PAH metabolites [ 9 , 10 , 31 , 33 , 34 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 ]. As demonstrated by several authors, the highest concentrations of urinary PAH metabolites correspond to the compounds of respective PAHs having lower molecular weights [ 9 , 33 , 34 , 40 , 43 , 44 , 46 ].…”

Section: Selected Chemicalsmentioning

confidence: 99%

Human Biomonitoring of Selected Hazardous Compounds in Portugal: Part I—Lessons Learned on Polycyclic Aromatic Hydrocarbons, Metals, Metalloids, and Pesticides

et al. 2021

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Human biomonitoring (HBM) data provide information on total exposure regardless of the route and sources of exposure. HBM studies have been applied to quantify human exposure to contaminants and environmental/occupational pollutants by determining the parent compounds, their metabolites or even their reaction products in biological matrices. HBM studies performed among the Portuguese population are disperse and limited. To overcome this knowledge gap, this review gathers, for the first time, the published Portuguese HBM information concerning polycyclic aromatic hydrocarbons (PAHs), metals, metalloids, and pesticides concentrations detected in the urine, serum, milk, hair, and nails of different groups of the Portuguese population. This integrative insight of available HBM data allows the analysis of the main determinants and patterns of exposure of the Portuguese population to these selected hazardous compounds, as well as assessment of the potential health risks. Identification of the main difficulties and challenges of HBM through analysis of the enrolled studies was also an aim. Ultimately, this study aimed to support national and European policies promoting human health and summarizes the most important outcomes and lessons learned through the HBM studies carried out in Portugal.

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“…Long exposure to low concentrations may cause low-grade in ammation [4] owing to alterations in platelet indices [14]. Chronic exposure to low concentrations of PAHs has also been estimated from cross-sectional datasets [15], but such a design may not re ect the effects of PAHs on white blood cells accurately, leading to con icting results [16] [17].…”

Section: Introductionmentioning

confidence: 99%

Long-term Exposure to Low Concentrations of Polycyclic Aromatic Hydrocarbons and Alterations in Platelet Indices: A Longitudinal Study in China

Cui¹,

Zhang²,

Zhang³

et al. 2021

Preprint

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Background High concentrations of polycyclic aromatic hydrocarbons (PAHs) can induce inflammatory and immune responses by affecting platelet indices. However, studies into low-concentration, non-occupational exposures are inconclusive in cross-sectional cohorts. We investigated low-concentration exposure to PAHs and alterations in platelet indices using a longitudinal dataset. Methods We recruited 418 participants from Northern China between 2014 and 2017 and followed each subject for three consecutive years; 222 were included in the analysis. Demographic information was collected by questionnaire and blood and urine were sampled annually. We measured the levels of eight urinary PAH metabolites representative of exposure to PAHs. Generalised mixed models and general linear mixed models were used to estimate correlations between PAH exposure, platelet indices, and covariates.Results We found dose–response correlations between urinary 1-hydroxynaphthalene, 2-hydroxyphenanthrene, 1-hydroxyphenanthrene, and 1-hydroxypyrene and platelet counts, as well as correlations between urinary 9-hydroxyfluorene levels and platelet distribution width, mean platelet volume, and platelet-large cell ratio. In subgroup analysis, 9-hydroxyfluorene levels were associated with mean platelet volume in participants exposed to second-hand smoke (odds ratio: 0.983; 95% confidence interval: 0.971–0.994) and with platelet distribution width in participants who were not exposed to second-hand smoke (odds ratio: 0.955; 95% confidence interval: 0.913–0.999).Conclusions Long-term exposure to low concentrations of PAHs affects platelet count, platelet distribution width, mean platelet volume, and platelet-large cell ratio, and the effects may be modified by exposure to second-hand smoke.

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Urinary polycyclic aromatic hydrocarbon metabolites among 3-year-old children from Krakow, Poland

Cited by 32 publications

References 40 publications

Variability in urinary biomarkers of human exposure to polycyclic aromatic hydrocarbons and its association with oxidative stress

Variability in urinary biomarkers of human exposure to polycyclic aromatic hydrocarbons and its association with oxidative stress

Human Biomonitoring of Selected Hazardous Compounds in Portugal: Part I—Lessons Learned on Polycyclic Aromatic Hydrocarbons, Metals, Metalloids, and Pesticides

Long-term Exposure to Low Concentrations of Polycyclic Aromatic Hydrocarbons and Alterations in Platelet Indices: A Longitudinal Study in China

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