Urinary Output of Total and Individual Fractions of 17-Ketosteroids in Patients with Acne

Sauter, Lilianna S.

doi:10.1159/000254493

Cited by 5 publications

(1 citation statement)

References 28 publications

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“…On the whole, previous studies have been characterized by inadequate methods of analysis. In a review published in 1965 [11], it is concluded that measure ment of urinary excretion of total and fractional 17-ketosteroids can hardly reveal increased formation of androgenic substances in patients with acne. Subsequent literature comprised a series of controversial reports, but several authors were able to demonstrate changes in the androgen pro duction in acne patients.…”

Section: Discussionmentioning

confidence: 99%

Cyproterone Acetate in the Treatment of Acne vulgaris in Adult Females

Hansted¹,

Reymann²

1982

Dermatology

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22 adult females with therapy-resistant acne vulgaris were treated for 12 months with Diane®¹, a drug containing cyproterone acetate and ethinylestradiol. Treatment was withdrawn in 7 patients because of side-effects or lack of effect. In the remaining 15 patients, the treatment had extremely promising results, from 70 to 90% improvement of the acne. In a remarkably high number of patients, the androgen production, measured by the urinary excretion of fractional 17-ketosteroids, was elevated. None of these patients had signs of endocrinological diseases, in particular no cases of hirsutism of Stein-Leventhal syndrome were found. The current concept of the course of acne is that the conversion in the skin of testosterone to dehydrotestosterone is increased. The finding of an elevated urinary excretion of androgenic substances in this group of acne patients indicates that the pathogenesis is far more complicated.

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Section: Discussionmentioning

confidence: 99%