Urinary NGAL and KIM-1 Are the Early Detecting Biomarkers of Preterm Infants with Acute Kidney Injury

Abstract

Background: Acute kidney injury (AKI) is common in neonates. However, early diagnosis is difficult. Different biomarkers for early diagnosis of AKI, such as NGAL, KIM-1, Cys-C, IL-18, β2-microglobulin have been proposed. But regarding premature infant, there is very little research that has been reported. Objectives: To investigate the role of urinary NGAL and Kim-1 biomarkers for early diagnosis of AKI in premature neonates. Methods: Eighty cases were divided into experimental group (60 cases) and controls group (20 cases). Of 60 cases, 24 patients met the criteria for AKI group; the remaining 36 were non-AKI group. Blood and urine samples, 1 ml each, were collected from all subjects at first day, second day, third day and seventh day of life. Urine NGAL and KIM-1 were measured by ELISA. Results: The urinary NGAL and KIM-1 are significantly higher in AKI group than Non-AKI group and normal control group in the first three days. They present earlier than classical Scr. Conclusion: Urinay NGAL and Kim-1 are beneficial biomarkers for the early diagnosis of AKI in preterm neonates.

Urinary metabolomics study of vancomycin-associated nephrotoxicity based on ultra-performance liquid chromatography coupled with quadrupole-time-of-flight mass spectrometry

“…KIM-1 has proved to be an outstanding indicator of kidney injury in the rat, outperforming blood urea nitrogen and serum creatinine as early predictors of kidney injury. 14,15 There was a significant difference in KIM-1 and the pathological section also demonstrating that the kidney was slightly damaged on D2. It showed a difference in BUN between control group and treatment group, while creatinine showed no differences, and the pathological section also showed mild to moderate renal injury in treatment group on D4.…”

A Rare Case of Staphylococcal Toxic Shock Syndrome in a Neonate

“…A significant rise in serum creatinine is seen only after 48 to 72 hours of renal insult and is detected when more than 50% of the glomerular filtration rate (GFR) is lost [ 18 ]. The new biomarkers such as neutrophil gelatinase lipoprotein (NGAL), cystatin C (CysC), and kidney injury molecule-1 (KIM-1) are beneficial in early detection of AKI in neonates, including premature babies [ 18 , 19 ]. However, there are limited studies regarding these new biomarkers in neonates and they may not be available in resource-limited regions.…”

Evaluation of the state of tubular epithelium in low birth weight infants with ischemic ­nephropathy

“…Таким образом, у маловесных новорождённых с ИН различных степеней тяжести концентрации NGAL и KIM-1 повышаются на 1-е сутки жизни (p=0,001) что свидетельствует о повреждении эпителия канальцев почек уже в первые часы после ишемии, так как ни NGAL, ни KIM-1 не экспрессируются в мочу при нор-мальных почках, а высокие их концентрации в динамике (p=0,001) на 7-10-е сутки указывают на степень тяжести и продолжительность ишемического повреждения почек. Наши исследования совпадают с недавними исследованиями, проведёнными Hongzhu Lu и соавт., которые проверяли уровни этих биомаркёров в моче у недоношенных новорождённых с острым повреждением почек и также наблюдали резкий и ранний подъём уровня KIM-1 и NGAL в моче при нормальной концентрации креатинина в плазме крови [9].…”