Aim. The study of the diagnostic value of KIM-1 and NGAL in urine and cystatin C in the blood plasma of low birth weight infants with ischemic nephropathy. Methods. 150 newborns were divided into 3 groups: main group 72 low birth weight infants with manifestations of ischemic nephropathy divided into three subgroups: group 1A mild (n=36), 1B moderate (n=20), 1C severe (n=16); comparioson group 28 low birth weight infants without the evidence of ischemic nephropathy; control group 50 healthy newborns (20 full-term and 30 preterm).To assess the state of tubular epithelium of the kidneys, the levels of KIM-1 and NGAL were measured in the urine of neonates, to assess the state of glomerular filtration the level of сystatin C in the blood plasma was determined. Samples of blood and urine were collected twice, on days 1 to 3 and 7 to 10. Biomarker levels were determined by solid-phase enzyme immunoassay. Results. In the main group on day 1 to 3 of life KIM-1 and NGAL in the urine were significantly elevated compared to the control group (p 0.001). On day 7 to 10 the level of KIM-1 in the urine in subgroup 1A decreased (0.980.09 ng/dl), while remaining significantly higher compared to the control group, and in subgroups 1B and 1C it increased to 1.240.10 and 1.360.12 ng/dl, respectively. On day 7 to 10 of life the concentration of NGAL in the urine of children of all three subgroups declined, remaining significantly high compared to the control values. Сoncentration of cystatin C was significantly high only in newborns of subgroup 1C (p 0.001). Conclusion. Molecules of NGAL and KIM-1 are early markers of the renal ischemic injury in low birth weight infants who suffered perinatal hypoxia, and cystatin C cannot be considered an early predictor of renal damage in low birth weight infants with ischemic nephropathy as its level in the blood rises only in severe damage.
(35%); cardiac (19%); non-cardiac anomaly (15%) and syndromal (12%). Of the 52 infants born alive, 20 (39%) survived to hospital discharge. Survival with idiopathic hydrops was 28%. Conclusions Overall survival in infants born alive with hydrops was 39%. Idiopathic hydrops was the most common diagnosis and had one of the poorest survival rates. PS-231EFFECT Background and aims The purpose of this study was to develop a population pharmacokinetics model (Pop PK) for ranitidine in newborns, and to determine the effect of nutritional state (NS) and gestational age (GA). The protocol was approved by the bioethics committee.Methods Fifty newborn (20 females and 30 males) were included. Their (GA) was as follows: 6 pre-term, small (SGA); 20 pre-term, appropriate (AGA); 4 pre-term, large (LGA); 7 SGA of full term; and 13 AGA of full term. Children received 3 mg/kg/day IV bolus of ranitidine; two blood samples were collected at each of the following times obtained randomly to: 0, 0.5, 0.75, 1, 2, 4, and 8 h from every newborn. The ranitidine levels were determined using HPLC technique. For the population pharmacokinetics (Pop PK) of ranitidine was used with MONOLIX MLXTRANS 4.2.2 ® program; data were fitted to bicompartimental model with first-order kinetics. Background The brain tissue is very sensitive to hypoxia-ischemia and all the changes occurring within it are well studied and easily diagnosed through laboratory and instrumental methods of examination. In contrast, there are few studies examining the influence of hypoxia-ischemia on kidneys in LBW newborns. Aim To determine the degree of hypoxic-ischaemic renal injury in LBW infants with various grades of IVH using new biomarkers of renal injury such as KIM-1 and uNGAL. Methods We studied 68/94 LBW infants (GA 28-36 weeks) with IVH (IVH grades I-II (N = 43) and III-IV (N = 25)) and conducted neurosonography and Doppler ultrasound tests of renal arteries. Urine samples were collected on days 1-3 and 7-10 after birth to determine KIM-1 and uNGAL levels. Results The comparison of the IVH groups I-II and III-IV (Table 1) and the control group (N = 26) shows that the levels of biomarkers KIM-1 and uNGAL significantly increased in grades III--IV IVH infants (p < 0,05). Conclusion This study finds that severity of renal damage depends on the grade of IVH and shows that KIM-1 and uNGAL are the most sensitive and early markers of hypoxic damage of tubular parts of a kidney.
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