Urinary neopterin and total neopterin measurements allow monitoring of oxidative stress and inflammation levels of knee and hip arthroplasty patients

Baxter-Parker, Gregory; Roffe, Lloyd; Moltchanova, Elena; Jefferies, Jay; Raajasekar, Siddarth; Hooper, Gary J.; Gieseg, Steven P.

doi:10.1371/journal.pone.0256072

Cited by 4 publications

(3 citation statements)

References 42 publications

(53 reference statements)

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“…NPT is in the family of pteridines and is included in several oxidation–reduction reactions in the body [ 8 , 29 ]. NPT concentrations also increase during pregnancy, are very elevated in neonates, and gradually decrease with age.…”

Section: Discussionmentioning

confidence: 99%

Assessment of serum neopterin and calprotectin as biomarkers for subclinical inflammation in patients with familial Mediterranean fever

et al. 2022

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Background Familial Mediterranean fever (FMF) is the most common autoinflammatory disease characterized by short, repeated, and self-limiting attacks of fever and serositis. Subclinical inflammation can persist in the periods with no symptoms and result in amyloidosis even with colchicine treatment. Neopterin and calprotectin have been considered essential players in inflammation and immune response. Aim The study was aimed to measure serum levels of neopterin and calprotectin in patients with FMF in the attack-free period. Methods A total of 160 participants were recruited from the rheumatology department in this single-center, case–control study. Individuals having the inclusion criteria were divided into healthy controls ( n = 80) and FMF ( n = 80). The laboratory data were acquired from the electronic registration database. Serum calprotectin and neopterin were measured with ELISA test kits. FMF patients and healthy controls’ laboratory findings were compared. Results FMF patients’ serum red cell distribution width (RDW), calprotectin, and neopterin values were significantly higher compared to healthy controls. There were no statistically significant differences between calprotectin and neopterin regarding gender, family history, and colchicine response of the FMF patients. Conclusions Calprotectin, neopterin, and RDW can be valuable marker candidates to be used in the follow-up of subclinical inflammation in FMF patients.

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Section: Discussionmentioning

confidence: 99%

Assessment of serum neopterin and calprotectin as biomarkers for subclinical inflammation in patients with familial Mediterranean fever

et al. 2022

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“…The production of neopterin during pregnancy may serve an adaptive function similar to its role during infections and inflammation [50][51][52]. It may counteract hyperinflammation during the processes of implantation and childbirth and reduce oxidative stress during the development of the embryo, fetus and placenta [53][54][55].…”

Section: (B) Urinary Neopterin Levels Before During and After Pregnan...mentioning

confidence: 99%

Modulation of cell-mediated immunity during pregnancy in wild bonobos

Behringer,

Deimel,

Ostner

et al. 2024

Biol. Lett.

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During pregnancy, the mammalian immune system must simultaneously protect against pathogens while being accommodating to the foreign fetal tissues. Our current understanding of this immune modulation derives predominantly from industrialized human populations and laboratory animals. However, their environments differ considerably from the pathogen-rich, resource-scarce environments in which pregnancy and the immune system co-evolved. For a better understanding of immune modulation during pregnancy in challenging environments, we measured urinary neopterin, a biomarker of cell-mediated immune responses, in 10 wild female bonobos ( Pan paniscus ) before, during and after pregnancy. Bonobos, sharing evolutionary roots and pregnancy characteristics with humans, serve as an ideal model for such investigation. Despite distinct environments, we hypothesized that cell-mediated immune modulation during pregnancy is similar between bonobos and humans. As predicted, neopterin levels were higher during than outside of pregnancy, and highest in the third trimester, with a significant decline post-partum. Our findings suggest shared mechanisms of cell-mediated immune modulation during pregnancy in bonobos and humans that are robust despite distinct environmental conditions. We propose that these patterns indicate shared immunological processes during pregnancy among hominins, and possibly other primates. This finding enhances our understanding of reproductive immunology.

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“…This relationship has been clearly shown in studies of exercise and impact-induced injury during intense physical activity [ 82 ]. Urinary Nep and total Nep (Nep + H 2 Nep) levels are indicative of oxidative stress and trauma-induced inflammation [ 83 ].…”

Section: Different Oxidation States Relate To Different Biological Ro...mentioning

confidence: 99%

Insights into Molecular Structure of Pterins Suitable for Biomedical Applications

Buglak

Kapitonova

Vechtomova

et al. 2022

IJMS

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Pterins are an inseparable part of living organisms. Pterins participate in metabolic reactions mostly as tetrahydropterins. Dihydropterins are usually intermediates of these reactions, whereas oxidized pterins can be biomarkers of diseases. In this review, we analyze the available data on the quantum chemistry of unconjugated pterins as well as their photonics. This gives a comprehensive overview about the electronic structure of pterins and offers some benefits for biomedicine applications: (1) one can affect the enzymatic reactions of aromatic amino acid hydroxylases, NO synthases, and alkylglycerol monooxygenase through UV irradiation of H4pterins since UV provokes electron donor reactions of H4pterins; (2) the emission properties of H2pterins and oxidized pterins can be used in fluorescence diagnostics; (3) two-photon absorption (TPA) should be used in such pterin-related infrared therapy because single-photon absorption in the UV range is inefficient and scatters in vivo; (4) one can affect pathogen organisms through TPA excitation of H4pterin cofactors, such as the molybdenum cofactor, leading to its detachment from proteins and subsequent oxidation; (5) metal nanostructures can be used for the UV-vis, fluorescence, and Raman spectroscopy detection of pterin biomarkers. Therefore, we investigated both the biochemistry and physical chemistry of pterins and suggested some potential prospects for pterin-related biomedicine.

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Urinary neopterin and total neopterin measurements allow monitoring of oxidative stress and inflammation levels of knee and hip arthroplasty patients

Cited by 4 publications

References 42 publications

Assessment of serum neopterin and calprotectin as biomarkers for subclinical inflammation in patients with familial Mediterranean fever

Assessment of serum neopterin and calprotectin as biomarkers for subclinical inflammation in patients with familial Mediterranean fever

Modulation of cell-mediated immunity during pregnancy in wild bonobos

Insights into Molecular Structure of Pterins Suitable for Biomedical Applications

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