Assessment of serum neopterin and calprotectin as biomarkers for subclinical inflammation in patients with familial Mediterranean fever

Tezcan, Dilek; Onmaz, Duygu Eryavuz; Sivrikaya, Abdullah; Hakbilen, Selda; Körez, Muslu Kazım; Gülcemal, Semral; Yılmaz, Sema

doi:10.1007/s11845-022-03173-w

Cited by 4 publications

(2 citation statements)

References 39 publications

(38 reference statements)

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“…This study was conducted with 70 children; 35 of them were diagnosed with FMF according to the new pediatric diagnostic criteria of FMF (12), and all FMF patients were during the attackfree period. Thirty-five apparently healthy age and sex-matched children were enrolled as a control group.…”

Section: Resultsmentioning

confidence: 99%

“…Familial Mediterranean fever (FMF) was reported to be associated with increased levels of fecal calprotectin (CLP), suggesting its potential utility in diagnosing and monitoring FMF patients (10). Increased serum CLP levels was also observed in adults with FMF during episodes (11) and between attacks (12). Our study aimed to assess serum calprotectin (CLP) levels among children with FMF during the attack-free periods compared to healthy age and sex-matched control group.…”

Section: Introductionmentioning

confidence: 98%

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Serum Calprotectin in Children with Familial Mediterranean Fever

Marzouk,

Abdel Maksoud,

Mahmoud

et al. 2024

Pediatric Sciences Journal

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Background: Familial Mediterranean fever (FMF) is the most prevalent inherited autoinflammatory disease worldwide. Ongoing subclinical inflammation, induces amyloidosis, even during the attack-free periods despite colchicine therapy. Serum calprotectin (CLP) belongs to the S100 protein family and was proposed as an indicator of inflammation in several diseases. Aim of the work:To evaluate serum calprotectin (CLP) levels among children with FMF during the attack-free periods. Patients and Methods: This cross-sectional case-control study included 35 children diagnosed with FMF in the attack-free period who were following at the Pediatric Rheumatology Outpatient Clinic, Children's Hospital, Faculty of Medicine Cairo University, and 35 children as a control group. This study was conducted during November 2020 to April 2021. Serum CLP was measured by ELISA. Results: The mean ± SD age of our studied FMF cohort was 9.23 ± 2.6 years; 15 (42.9%) were males, and 20 (57.1%) were females compared to the mean ± SD age of the control group 9.0 ± 2.6, 21 (60%) were males, and 14 (40%) were females(p=0.665 and p=0.151 respectively). The range of serum calprotectin levels among our FMF patients during the attack-free period was (15.4-1306) ng/ml, while the range in the control group, its range was (0.2 -77) ng/ml with mean± SD was 24.62±16.66 ng/ml, (p-value = 0.001). Of those with FMF 25 (71.4%) had normal level of CLP (mean± SD= 31.6± 9.2 and range=15.4 -48.6 ng/ml) and 10 (28.6%) had elevated CLP (mean± SD= 296.79±442.33 and range= 55 -1306 ng/ml). There were no significant correlations between serum CLP levels and FMF clinical presentations, disease severity scores, different laboratory data, or types of MEFV gene mutation p-values = 0.697, 0.696 and 0.146 respectively. Conclusion: Serum CLP levels were elevated in a subset of children with FMF during the attack-free period. Serum CLP did not correlate with any studied parameter. The specificity and sensitivity of diagnostic accuracy and outcome prognostic ability of CLP in FMF remain to be studied.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 98%

Serum Calprotectin in Children with Familial Mediterranean Fever

Marzouk,

Abdel Maksoud,

Mahmoud

et al. 2024

Pediatric Sciences Journal

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Role of serum calprotectin in identifying familial Mediterranean fever attacks

Polat,

Omma,

Gokcen

et al. 2024

Ir J Med Sci

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Exploring S100A8/A9, neopterin, and MMP3 in familial Mediterranean fever

Kilinc,

Akdeniz,

Taskin

et al. 2024

Clinical and Experimental Immunology

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Familial mediterranean fever (FMF) is characterized by inflammatory attacks due to overactivation of pyrin inflammasome. This study aimed to investigate the reliability of S100A8/A9, neopterin, and matrix metalloproteinase 3 (MMP3) at monitoring subclinical inflammation and disease activity, and at differentiating FMF attacks from appendicitis, the most common misdiagnosis among FMF patients. Blood samples (n=75), comprising from FMF patients during an attack (n=20), the same FMF patients during the attack-free period (n=14), patients with appendicitis (n=24), and healthy volunteers (n=17) were obtained. Duplicate determinations of S100A8/A9, neopterin, and MMP-3 levels were conducted using the enzyme-linked immunosorbent assay (ELISA). FMF patients with and without attack and patients with appendicitis had significantly elevated S100A8/A9 levels compared to healthy volunteers (p-values: <0.001, 0.036, 0.002, respectively). Patients with appendicitis and FMF patients with and without attack had significantly increased serum neopterin levels compared to healthy volunteers (p-value: <0.001). MMP3 levels were significantly higher among patients with appendicitis and FMF patients during attack compared to healthy controls (p-values: <0.001, 0.001). Serum levels of S100A8/A9, neopterin, and MMP3 were increased significantly during attacks compared to attack-free periods among FMF patients (p-values: 0.03, 0.047, 0.007). S100A8/A9 emerges as a valuable marker for monitoring disease activity. Neopterin and S100A8/A9 might help physicians to monitor subclinical inflammation during the attack-free periods of FMF patients. MMP3 might aid in diagnosing FMF attacks when distinguishing between attack and attack-free periods is challenging.

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Assessment of serum neopterin and calprotectin as biomarkers for subclinical inflammation in patients with familial Mediterranean fever

Cited by 4 publications

References 39 publications

Serum Calprotectin in Children with Familial Mediterranean Fever

Serum Calprotectin in Children with Familial Mediterranean Fever

Role of serum calprotectin in identifying familial Mediterranean fever attacks

Exploring S100A8/A9, neopterin, and MMP3 in familial Mediterranean fever

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